{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T12:34:58Z","timestamp":1786710898280,"version":"build-2736575974"},"reference-count":78,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyze and synthesize the information available from five pivotal, large-scale, multicenter, observational studies (CHECK, OAI, FNIH Biomarkers Consortium, IMI-APPROACH, and MOST) focusing on knee osteoarthritis (OA), which can be used to elucidate disease progression, risk factors, and the effectiveness of potential interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>For this narrative review, a comprehensive literature search and data extraction from official web pages and scientific databases were conducted to compare methodologies, in- and exclusion criteria, outcomes, and cohort characteristics across the studies. Thematic, comparative, and qualitative analyses were employed to identify trends, commonalities, and disparities among the findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The studies collectively enhanced understanding of the onset and progression of knee OA, and in several of the studies, hip OA, emphasizing the importance of both systemic and local risk factors. Advanced imaging and biomarkers are important components in all the cohorts, with the goal of aiding early diagnosis and tracking disease progression. All cohorts evaluated unique markers generally not available in the other cohorts, while other factors overlap, suggesting possibilities for combining or cross-validating between cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The collaborative efforts of major OA research significantly advance our understanding of knee OA. These studies highlight the importance of a multifaceted approach, integrating advanced imaging, biomarkers, and longitudinal data to tackle the complexities of OA. By synthesizing findings and addressing knowledge gaps such as heterogeneity of patients and used measurements, and use of novel pain measures, future research can develop more effective diagnostic tools and treatments, ultimately enhancing the quality of life for OA patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19476035251326276","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T09:01:18Z","timestamp":1742374878000},"page":"475-489","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparing Five Major Knee Osteoarthritis Cohort Studies: Similarities, Differences, and Unique Aspects of CHECK, OAI, FNIH, IMI-APPROACH, and MOST"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1327-5973","authenticated-orcid":false,"given":"Mariia","family":"Oliinyk","sequence":"first","affiliation":[{"name":"Department of Rheumatology &amp; Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands"},{"name":"Department of Internal Medicine No. 3 and Endocrinology, Kharkiv National Medical University, Kharkiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8825-6486","authenticated-orcid":false,"given":"Simon C.","family":"Mastbergen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology &amp; Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4464-8493","authenticated-orcid":false,"given":"Anne Karien C. A.","family":"Marijnissen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology &amp; Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Felson","sequence":"additional","affiliation":[{"name":"School of Medicine, Boston University, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Sydney Musculoskeletal Health, Kolling Institute, The University of Sydney, Sydney, NSW, Australia"},{"name":"Rheumatology Department, Northern Sydney Local Health District, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micheal C.","family":"Nevitt","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics, University of California, San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrie","family":"Weinans","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands"},{"name":"Department of Biomechanical Engineering, TU Delft, Delft, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1929-6350","authenticated-orcid":false,"given":"Myl\u00e8ne P.","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology &amp; Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.04.011"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21258"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216515"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu177"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205310"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11420-011-9235-y"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2020.05.008"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-035101"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2523082197"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.113"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.39731"},{"issue":"1","key":"e_1_3_2_13_2","article-title":"Prevalence of knee symptoms and radiographic and symptomatic knee osteoarthritis in African Americans and Caucasians: the Johnston County Osteoarthritis Project","volume":"34","author":"Jordan JM","year":"2007","unstructured":"Jordan JM, Helmick CG, Renner JB, Luta G, Dragomir AD, Woodard J, et al. Prevalence of knee symptoms and radiographic and symptomatic knee osteoarthritis in African Americans and Caucasians: the Johnston County Osteoarthritis Project. J Rheumatol. 2007;34(1):172-80.","journal-title":"J Rheumatol"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","unstructured":"Murphy LB Moss S Do BT Helmick CG Schwartz TA Barbour KE et al. Annual incidence of knee symptoms and four knee osteoarthritis outcomes in the Johnston County Osteoarthritis Project. Arthritis Care Res. 2016;68(1):55-65. doi:10.1002\/acr.22641","DOI":"10.1002\/acr.22641"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2013.04.014"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","unstructured":"Hunter D Nevitt M Lynch J Kraus VB Katz JN Collins JE et al. Longitudinal validation of periarticular bone area and 3D shape as biomarkers for knee OA progression? data from the FNIH OA Biomarkers Consortium. Ann Rheum Dis. 2016;75(9):1607-14. doi:10.1136\/annrheumdis-2015-207602","DOI":"10.1136\/annrheumdis-2015-207602"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.05.002"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa809"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20305"},{"issue":"12","key":"e_1_3_2_20_2","article-title":"Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee","volume":"15","author":"Bellamy N","year":"1988","unstructured":"Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW. Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol. 1988;15(12):1833-40.","journal-title":"J Rheumatol"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2002.001784"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1053\/joca.2002.0838"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20543"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1207\/S15327558IJBM1004_5"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7133.736"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-004-0965-9"},{"key":"e_1_3_2_28_2","first-page":"1","volume-title":"Pati\u00ebntenpanel Chronisch Zieken: kerngegevens 1998","author":"Rijken PM","unstructured":"Rijken PM, Foets M, Peters L, Bruin AFd, Dekker J. Pati\u00ebntenpanel Chronisch Zieken: kerngegevens 1998. Utrecht, The Netherlands: NIVEL, Pati\u00ebntenpanel Chronisch Zieken; 1998. 1-98 p."},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.033977"},{"key":"e_1_3_2_30_2","article-title":"Plausibiliteit nieuwe metingen algemene gezondheid en leefstijlen 2001","author":"Botterweck A","year":"2001","unstructured":"Botterweck A, Frenken F, Janssen S, Rozendaal L, Vree Md, Otten F. Plausibiliteit nieuwe metingen algemene gezondheid en leefstijlen 2001 [Plausibility new measurements general health and lifestyles]. Heerlen, The Netherlands: Centraal Bureau voor de Statistiek; 2001.","journal-title":"Heerlen, The Netherlands: Centraal Bureau voor de Statistiek;"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200005)43:5<953::AID-ANR1>3.0.CO;2-Q"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.107"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","unstructured":"Kang EH Lee YJ Kim TK Chang CB Chung JH Shin K et al. Adiponectin is a potential catabolic mediator in osteoarthritis cartilage. Arthritis Res Ther. 2010;12(6):R231. doi:10.1186\/ar3218","DOI":"10.1186\/ar3218"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2011.04.009"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080997"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.04.004"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209252"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","unstructured":"Angelini F Widera P Mobasheri A Blair J Struglics A Uebelhoer M et al. Osteoarthritis endotype discovery via clustering of biochemical marker data. Ann Rheum Dis. 2022;81(5):666-75. doi:10.1136\/annrheumdis-2021-221763","DOI":"10.1136\/annrheumdis-2021-221763"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.16.4.494"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.11.009"},{"key":"e_1_3_2_41_2","unstructured":"Burnett SJ Hart DJ Spector TD. A radiographic atlas of osteoarthritis. New York: Springer; 1994."},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.05.007"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","unstructured":"Marijnissen AC Vincken KL Vos PA Saris DB Viergever MA Bijlsma JW et al. Knee Images Digital Analysis (KIDA): a novel method to quantify individual radiographic features of knee osteoarthritis in detail. Osteoarthritis Cartilage. 2008;16(2):234-43. doi:10.1016\/j.joca.2007.06.009","DOI":"10.1016\/j.joca.2007.06.009"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-002-0603-z"},{"key":"e_1_3_2_45_2","unstructured":"Felson DT Nevitt MC Yang M Clancy M Niu J Torner JC et al. A new approach yields high rates of radiographic progression in knee osteoarthritis. J Rheumatol. 2008;35(10):2047-54."},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.155119"},{"key":"e_1_3_2_47_2","unstructured":"Kellgren JH Lawrence JS. The epidemiology of chronic rheumatism. Atlas of standard radiographs. Vol. 2. Oxford UK: Blackwell Scientific; 1963."},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.10.017"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1053\/joca.2000.0337"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2012.2202660"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204052"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.Joca.2011.05.004"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2007.12.015"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2019.02.721"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2003.11.003"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2008.03.001"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.06.006"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.39324"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-016-1310-6"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1177\/19476035241287694"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2022.10.001"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1177\/1947603519888793"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-019-05507-1"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.103B2.BJJ-2020-1050.R1"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ostima.2024.100232"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1007\/S00256-024-04666-8\/"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22586"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2024.02.877"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.2938"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.39488"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ostima.2023.100125"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2021-002025"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2021.105171"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1177\/1120700020943853"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.170208"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-020-00640-5"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780300811"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.53.3.158"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-022-02907-6"}],"container-title":["CARTILAGE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19476035251326276","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19476035251326276","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19476035251326276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:53:15Z","timestamp":1786708395000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19476035251326276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,19]]},"references-count":78,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1177\/19476035251326276"],"URL":"https:\/\/doi.org\/10.1177\/19476035251326276","relation":{},"ISSN":["1947-6035","1947-6043"],"issn-type":[{"value":"1947-6035","type":"print"},{"value":"1947-6043","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,19]]}}}