{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T12:35:09Z","timestamp":1786710909749,"version":"build-2736575974"},"reference-count":34,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Trapeziometacarpal osteoarthritis (TMO) is a prevalent degenerative condition. While conservative treatments such as physiotherapy, drugs, and corticosteroid or hyaluronic acid injections offer symptomatic relief, their long-term efficacy remains debated. A recent study has explored collagen-based fillers as an alternative, but long-term clinical outcomes are still under investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study enrolled 64 patients diagnosed with TMO, stratified into 2 groups based on the Eaton-Littler classification (grade 1-2: group A; grade 3-4: group B). All patients received a percutaneous intra-articular injection of a cell-free collagenic hydrogel under ultrasound guidance. Outcomes were assessed more than 2 years using the Numeric Rating Scale (NRS) for pain, Jamar and Pinch tests for grip strength, and the Disability of the Arm, Shoulder, and Hand (DASH) questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In both groups, all studied variables demonstrated a significant improvement (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) that was sustained in the long term. Notably, greater improvement was observed in strength tests for Group A patients and in the DASH score for Group B patients. The most substantial improvement occurred between 2 and 6 months post-procedure. No adverse events were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Collagen-based filler injections provide long-term pain relief and functional improvement in TMO, representing a promising minimally invasive treatment option.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registry name:<\/jats:title>\n                    <jats:p>NCT06881186<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19476035251354926","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T06:50:25Z","timestamp":1751352625000},"page":"467-474","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The Use of Collagen-Based Filler for Trapeziometacarpal Osteoarthritis: Long-Term Follow-Up and Future Applications"],"prefix":"10.1177","volume":"17","author":[{"given":"Massimo","family":"Corain","sequence":"first","affiliation":[{"name":"Hand Surgery Unit, University Hospital of Verona\u2013Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niccol\u00f2","family":"Faccioli","sequence":"additional","affiliation":[{"name":"Radiology Unit, University Hospital of Verona\u2013Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7614-812X","authenticated-orcid":false,"given":"Umberto","family":"Lavagnolo","sequence":"additional","affiliation":[{"name":"Hand Surgery Unit, University Hospital of Verona\u2013Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy"},{"name":"Surgery, Dentistry, Maternity and Infant Department, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0712(21)00238-9"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0712(21)00237-7"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.E.00104"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-017-1870-0"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23079"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.062091"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2025.105849"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2022.07.011"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2024.02.001"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11552-015-9778-3"},{"issue":"4","key":"e_1_3_3_12_2","first-page":"45","article-title":"Intrarticular injections of hyaluronic acid for trapezio-metacarpal osteoarthritis: a systematic review","volume":"31","author":"Papalia R","year":"2017","unstructured":"Papalia R, Diaz LA, Torre G, Albo E, Tecame A, Sterzi S, et al Intrarticular injections of hyaluronic acid for trapezio-metacarpal osteoarthritis: a systematic review. 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