{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T04:26:49Z","timestamp":1793680009366,"version":"4.5.1"},"reference-count":33,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council of Taiwan","doi-asserted-by":"publisher","award":["MOST 105-2314-B-016-022"],"award-info":[{"award-number":["MOST 105-2314-B-016-022"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council of Taiwan","doi-asserted-by":"publisher","award":["110-2314-B-016-026-MY3"],"award-info":[{"award-number":["110-2314-B-016-026-MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of National Defense\u2014Medical Affairs Bureau","award":["MAB-105-071"],"award-info":[{"award-number":["MAB-105-071"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigated whether hyperbaric oxygen (HBO) therapy, initiated after disease establishment, exerts disease-modifying effects in a rat model of anterior cruciate ligament transection (ACLT)-induced post-traumatic osteoarthritis (PTOA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Thirty-six Sprague-Dawley rats underwent ACLT surgery. HBO therapy commenced at Week 11 (established OA phase) and continued for 6 weeks. Outcomes were assessed using Von Frey testing, multimodal 7T MRI (T2* quantification and pharmacokinetic DCE-MRI), and histopathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      By Week 10, ACLT induced significant mechanical allodynia, T2* prolongation, and SCB perfusion abnormalities (\n                      <jats:italic toggle=\"yes\">A<\/jats:italic>\n                      increase;\n                      <jats:italic toggle=\"yes\">k<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic toggle=\"yes\">ep<\/jats:italic>\n                      <\/jats:sub>\n                      ,\n                      <jats:italic toggle=\"yes\">k<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic toggle=\"yes\">el<\/jats:italic>\n                      <\/jats:sub>\n                      decrease). Following HBO intervention, the ACLT+HBO group exhibited a marked recovery in mechanical withdrawal threshold and significantly lower T2* values compared to the ACLT-only group (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.01). DCE-MRI demonstrated that HBO restored clearance kinetics (\n                      <jats:italic toggle=\"yes\">k<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic toggle=\"yes\">el<\/jats:italic>\n                      <\/jats:sub>\n                      ,\n                      <jats:italic toggle=\"yes\">k<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic toggle=\"yes\">ep<\/jats:italic>\n                      <\/jats:sub>\n                      ) and suppressed pathological blood volume (\n                      <jats:italic toggle=\"yes\">A<\/jats:italic>\n                      ), effectively remediating subchondral venous congestion. Histologically, HBO reduced OARSI scores and suppressed \u03b1-SMA-positive vascular invasion across the tidemark. These findings suggest that HBO therapy may alleviate PTOA by suppressing catabolic activity and normalizing pathological subchondral angiogenesis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HBO therapy, initiated post-pathogenesis, effectively attenuates nociception and preserves cartilage integrity by restoring subchondral microcirculatory homeostasis. These findings establish HBO as a potent, non-invasive disease-modifying strategy for PTOA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19476035261457601","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:03:36Z","timestamp":1780491816000},"page":"1516-1527","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hyperbaric Oxygen Therapy Improves Subchondral Perfusion and Cartilage Integrity in Established Osteoarthritis: A Pharmacokinetic DCE-MRI and T2* Quantification Study"],"prefix":"10.1177","volume":"17","author":[{"given":"Guo-Shu","family":"Huang","sequence":"first","affiliation":[{"name":"Tri-Service General Hospital"},{"name":"National Defense Medical University"},{"name":"Tri-Service General Hospital"},{"name":"National Defense Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9672-1077","authenticated-orcid":false,"given":"Shih-Wei","family":"Chiang","sequence":"additional","affiliation":[{"name":"Tri-Service General Hospital"},{"name":"National Defense Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiao-Chi","family":"Chen","sequence":"additional","affiliation":[{"name":"Academia Sinica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Jen","family":"Peng","sequence":"additional","affiliation":[{"name":"Tri-Service General Hospital"},{"name":"National Defense Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Juei","family":"Hsu","sequence":"additional","affiliation":[{"name":"Tri-Service General Hospital"},{"name":"National Defense Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun-Lun","family":"Huang","sequence":"additional","affiliation":[{"name":"National Defense Medical University"},{"name":"Tri-Service General Hospital"},{"name":"National Defense Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ching","family":"Chou","sequence":"additional","affiliation":[{"name":"Mackay Medical University"},{"name":"National Defense Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Huang","family":"Lin","sequence":"additional","affiliation":[{"name":"Academia Sinica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Chun","family":"Liu","sequence":"additional","affiliation":[{"name":"National Defense Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5504-5463","authenticated-orcid":false,"given":"Chao-Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"National Defense Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516629944"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13175063"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12178-019-09596-w"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2024.04.013"},{"issue":"11","key":"e_1_3_6_6_2","first-page":"25","article-title":"Post-traumatic osteoarthritis after ACL injury","volume":"97","author":"Racine J","year":"2014","unstructured":"Racine J, Aaron RK. 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