{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T03:04:35Z","timestamp":1789355075232,"version":"build-2803163510"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Thyroid cartilage calcification and glucose metabolism may vary with age and gender. This study investigated the role of [\n                      <jats:sup>18<\/jats:sup>\n                      F]-sodium fluoride ([\n                      <jats:sup>18<\/jats:sup>\n                      F]NaF) and 2-[\n                      <jats:sup>18<\/jats:sup>\n                      F]fluoro-2-deoxy-D-glucose ([\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG) PET\/CT in evaluating of physiological molecular calcification and glucose metabolism of thyroid cartilage with age.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective study analyzed [\n                      <jats:sup>18<\/jats:sup>\n                      F]NaF and [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET\/CT images from the CAMONA study (NCT01724749). Regions of interest were placed around the thyroid cartilage on CT images using OsiriX software. The mean standardized uptake value (SUVmean) was measured for [\n                      <jats:sup>18<\/jats:sup>\n                      F]NaF and [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET\/CT images. Pearson correlation coefficients were calculated to evaluate the effects of aging on [\n                      <jats:sup>18<\/jats:sup>\n                      F]NaF and [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG in the thyroid cartilage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 127 healthy subjects (65 females and 62 males) with a mean age of 48.46 \u00b1 14.13 (range 21\u201375) years for [\n                      <jats:sup>18<\/jats:sup>\n                      F]NaF PET\/CT and 114 healthy subjects (52 females and 62 males) with a mean age of 49.05 \u00b1 14.29 (range 22\u201375) years for [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET\/CT were included. A significant positive correlation was observed between age and SUVmean of [\n                      <jats:sup>18<\/jats:sup>\n                      F]NaF in the thyroid cartilage (r = 0.18, p = 0.04), indicating that molecular calcification of this cartilage increases with aging. However, the correlation between age and SUVmean of [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG in the thyroid cartilage was not statistically significant (r = -0.09, p = 0.31).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study presents a novel methodology for the determination of molecular calcification and glucose metabolism of laryngeal cartilage using [\n                      <jats:sup>18<\/jats:sup>\n                      F]NaF and [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET\/CT. Molecular calcification of thyroid cartilage increase with age, whereas glucose metabolism did not show a statistically significant correlation with age.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19476035261467882","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T17:52:37Z","timestamp":1789062757000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Application of [\n                    <sup>18<\/sup>\n                    F]NaF and [\n                    <sup>18<\/sup>\n                    F]FDG PET\/CT to Assess Molecular Calcification and Glucose Metabolism in Thyroid Cartilage"],"prefix":"10.1177","author":[{"given":"Niloofaralsadat","family":"Motamedi","sequence":"first","affiliation":[{"name":"Hospital of the University of Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5536-0869","authenticated-orcid":false,"given":"Shashi Bhushan","family":"Singh","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania"},{"name":"Department of Radiology, Stanford University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miraziz","family":"Ismoilov","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania"},{"name":"The University of Oklahoma Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saira K.","family":"Niazi","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bimash B.","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malia","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania"},{"name":"Department of Cardiology, Lewis Katz School of Medicine-Temple Heart and Vascular Institute, 3500 N Broad St, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Om H.","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Werner","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drew A.","family":"Torigian","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abass","family":"Alavi","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3300-7420","authenticated-orcid":false,"given":"Mona-Elisabeth","family":"Revheim","sequence":"additional","affiliation":[{"name":"Oslo University Hospital"},{"name":"University of Oslo"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26644"},{"key":"e_1_3_7_3_2","volume-title":"Trends and Patterns in the Ossification of Thyroid Cartilage. 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