{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T09:24:45Z","timestamp":1779009885507,"version":"3.51.4"},"reference-count":343,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroradiol J"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p>Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by the gradual onset of dementia. The pathological hallmarks of the disease are A\u03b2 amyloid plaques, neurofibrillary tangles (NFT), synaptic loss and reactive gliosis. Current diagnosis of AD is made by clinical, neuropsychologic, and neuroimaging assessments. Routine structural neuroimaging evaluation with computed tomography (CT) and magnetic resonance imaging (MRI) is based on nonspecific features such as atrophy, a late feature in the progression of the disease, hence the crucial importance of developing new approaches for early and specific recognition at the prodromal stages of AD. Functional neuroimaging techniques such as functional magnetic resonance imaging (fMRI), magnetic resonance spectroscopy (MRS), positron emission tomography (PET) and single photon emission computed tomography (SPECT), possibly in conjuction with other related A\u03b2 biomarkers in plasma and CSF, could prove to be valuable in the differential diagnosis of AD, as well as in assessing prognosis. With the advent of new therapeutic strategies aimed at reducing the A\u03b2 amyloid burden in the brain, there is increasing interest in the development of MRI contrast agents and PET and SPECT radioligands that will permit the assessment of A\u03b2 amyloid burden in vivo.<\/jats:p>","DOI":"10.1177\/197140090601900406","type":"journal-article","created":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T17:39:43Z","timestamp":1429724383000},"page":"453-474","source":"Crossref","is-referenced-by-count":12,"title":["<i>La Lunga Attesa<\/i>\n                    : Towards a Molecular Approach to Neuroimaging and Therapeutics in Alzheimer's Disease"],"prefix":"10.1177","volume":"19","author":[{"given":"V.L.","family":"Villemagne","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Centre for PET, Austin Health; Heidelberg, VIC, Australia"},{"name":"Department of Pathology, The University of Melbourne; VIC, Australia"},{"name":"The Mental Health Research Institute of Victoria, Parkville; VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Centre for PET, Austin Health; Heidelberg, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Cappai","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Melbourne; VIC, Australia"},{"name":"Centre for Neuroscience, The University of Melbourne; VIC, Australia"},{"name":"The Mental Health Research Institute of Victoria, Parkville; VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.J.","family":"Barnham","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Melbourne; VIC, Australia"},{"name":"The Mental Health Research Institute of Victoria, Parkville; VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.T.","family":"Fodero-Tavoletti","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Melbourne; VIC, Australia"},{"name":"The Mental Health Research Institute of Victoria, Parkville; VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.C.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Centre for PET, Austin Health; Heidelberg, VIC, Australia"},{"name":"Department of Medicine, The University of Melbourne; VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.L.","family":"Masters","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Melbourne; VIC, Australia"},{"name":"The Mental Health Research Institute of Victoria, Parkville; VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,8,1]]},"reference":[{"key":"bibr1-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1985.04060100083029"},{"key":"bibr2-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(02)02037-4"},{"key":"bibr3-197140090601900406","volume-title":"Histoires Extraordinaires par Edgar Poe","author":"Baudelaire C","year":"1856"},{"key":"bibr4-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.1_Suppl_1.S2"},{"key":"bibr5-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/51A.6.M313"},{"key":"bibr6-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-199601040-00002"},{"key":"bibr7-197140090601900406","volume-title":"Diagnostic and statistical manual","author":"American Psychiatric Association DSM-IV","year":"1994"},{"key":"bibr8-197140090601900406","volume-title":"International Classification of Diseases","year":"1992","edition":"10"},{"key":"bibr9-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"bibr10-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.9.1133"},{"key":"bibr11-197140090601900406","first-page":"93","volume":"15","author":"Petersen RC","year":"2000","journal-title":"Neurologia"},{"key":"bibr12-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.3.303"},{"key":"bibr13-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520400044042"},{"key":"bibr14-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1201\/b13239-66"},{"key":"bibr15-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511544873.030"},{"key":"bibr16-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-3396-5_6"},{"key":"bibr17-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:19:3:289"},{"key":"bibr18-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-7508-8_8"},{"key":"bibr19-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(05)70229-2"},{"key":"bibr20-197140090601900406","volume-title":"Dementia","author":"O'Brien J","year":"2000","edition":"2"},{"key":"bibr21-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1038\/nm0798-827"},{"key":"bibr22-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.12.1.171"},{"key":"bibr23-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1126\/science.2218531"},{"key":"bibr24-197140090601900406","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0306-4522(96)00577-5","volume":"78","author":"Lovestone S","year":"1997","journal-title":"Neuroscience"},{"key":"bibr25-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(03)00002-2"},{"key":"bibr26-197140090601900406","first-page":"65","volume-title":"Pathological diagnosis of Alzheimer's disease","author":"Geula C","year":"2000"},{"key":"bibr27-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.12.4245"},{"key":"bibr28-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(99)00027-8"},{"key":"bibr29-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1038\/357500a0"},{"key":"bibr30-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1038\/359325a0"},{"key":"bibr31-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1126\/science.1439760"},{"key":"bibr32-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(84)80190-4"},{"key":"bibr33-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.66.1.385"},{"key":"bibr34-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.7.3063"},{"key":"bibr35-197140090601900406","doi-asserted-by":"publisher","DOI":"10.3109\/13506129808995287"},{"key":"bibr36-197140090601900406","first-page":"165","volume-title":"Electron Microscopy of Proteins","author":"Cohen AS","year":"1982"},{"key":"bibr37-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1126\/science.1074069"},{"key":"bibr38-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb05554.x"},{"key":"bibr39-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(05)70232-2"},{"key":"bibr40-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7129.446"},{"key":"bibr41-197140090601900406","first-page":"410","volume":"45","author":"Masters CL","year":"1995","journal-title":"Arzneimittelforschung"},{"key":"bibr42-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.23.2208"},{"key":"bibr43-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072994"},{"key":"bibr44-197140090601900406","first-page":"426","volume-title":"Dementia","author":"Ritchie CW","year":"2005","edition":"3"},{"key":"bibr45-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.2.741"},{"key":"bibr46-197140090601900406","doi-asserted-by":"publisher","DOI":"10.3109\/13506120209114823"},{"key":"bibr47-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000706"},{"key":"bibr48-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6150.1457"},{"key":"bibr49-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.114.512.797"},{"key":"bibr50-197140090601900406","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF00687420","volume":"77","author":"Yamaguchi H","year":"1988","journal-title":"Acta Neuropathol (Berl)"},{"key":"bibr51-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.16.2094"},{"key":"bibr52-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199912)46:6<860::AID-ANA8>3.0.CO;2-M"},{"key":"bibr53-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199909290-00007"},{"key":"bibr54-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380219"},{"key":"bibr55-197140090601900406","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2001-3305"},{"key":"bibr56-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.12.1571"},{"key":"bibr57-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65184-X"},{"key":"bibr58-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7085"},{"key":"bibr59-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(91)90052-2"},{"key":"bibr60-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1126\/science.1566067"},{"key":"bibr61-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(02)02263-4"},{"key":"bibr62-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1126\/science.298.5595.962"},{"key":"bibr63-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)01030-2"},{"key":"bibr64-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)02031-2"},{"key":"bibr65-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1038\/399a023"},{"key":"bibr66-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb05552.x"},{"key":"bibr67-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1038\/360672a0"},{"key":"bibr68-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1126\/science.8424174"},{"key":"bibr69-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1126\/science.8191290"},{"key":"bibr70-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.25.11993"},{"key":"bibr71-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1038\/349704a0"},{"key":"bibr72-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1038\/ng1718"},{"key":"bibr73-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00192-6"},{"key":"bibr74-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1038\/376775a0"},{"key":"bibr75-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1038\/375754a0"},{"key":"bibr76-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1038\/nm0896-864"},{"key":"bibr77-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1038\/nm0197-67"},{"key":"bibr78-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1038\/383710a0"},{"key":"bibr79-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1126\/science.7638622"},{"key":"bibr80-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.16.9390"},{"key":"bibr81-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1126\/science.8346443"},{"key":"bibr82-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91705-Q"},{"key":"bibr83-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.5.1977"},{"key":"bibr84-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80230-5"},{"key":"bibr85-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199511093331902"},{"key":"bibr86-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.20.9649"},{"key":"bibr87-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90070-8"},{"key":"bibr88-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.8.3586"},{"key":"bibr89-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410430217"},{"key":"bibr90-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.141.4.1031"},{"key":"bibr91-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(03)00067-5"},{"key":"bibr92-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1038\/359322a0"},{"key":"bibr93-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(99)00058-5"},{"key":"bibr94-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1515\/REVNEURO.2000.11.4.329"},{"key":"bibr95-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.9.7.7737461"},{"key":"bibr96-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S1367-5931(99)00073-3"},{"key":"bibr97-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1306.012"},{"key":"bibr98-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.5.1488S"},{"key":"bibr99-197140090601900406","first-page":"309","volume":"36","author":"Atwood CS","year":"1999","journal-title":"Met Ions Biol Syst"},{"key":"bibr100-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1330"},{"key":"bibr101-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)01767-5"},{"key":"bibr102-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00404-9"},{"key":"bibr103-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2003.12.007"},{"key":"bibr104-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1007\/s000180050035"},{"key":"bibr105-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1054\/jocn.2001.1027"},{"key":"bibr106-197140090601900406","first-page":"275","volume":"18","author":"Saez TE","year":"2004","journal-title":"In Vivo"},{"key":"bibr107-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.34.20631"},{"key":"bibr108-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1038\/416535a"},{"key":"bibr109-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1021\/bi9904149"},{"key":"bibr110-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-04-01676.1993"},{"key":"bibr111-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.25.12243"},{"key":"bibr112-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100175200"},{"key":"bibr113-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1002\/0470868694.ch4"},{"key":"bibr114-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000165200"},{"key":"bibr115-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6448"},{"key":"bibr116-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-20-08876.1999"},{"key":"bibr117-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.6.3228"},{"key":"bibr118-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-11-04050.2000"},{"key":"bibr119-197140090601900406","first-page":"83","volume-title":"The pathophysiology of Alzheimer's disease","author":"Selkoe DJ","year":"2000"},{"key":"bibr120-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1358\/dnp.2002.15.2.668336"},{"key":"bibr121-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(02)00079-5"},{"key":"bibr122-197140090601900406","first-page":"115","volume-title":"Aging and the Brain","author":"Bowen DM","year":"1988"},{"key":"bibr123-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.4.454"},{"key":"bibr124-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1002\/gps.939"},{"key":"bibr125-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1002\/gps.937"},{"key":"bibr126-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3458.2003.tb00254.x"},{"key":"bibr127-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013128"},{"key":"bibr128-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.11.10.1407"},{"key":"bibr129-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199704243361704"},{"key":"bibr130-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1007\/BF01294728"},{"key":"bibr131-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199301213280305"},{"key":"bibr132-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1992.tb08880.x"},{"key":"bibr133-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-200001000-00002"},{"key":"bibr134-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-003-0069-8"},{"key":"bibr135-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1007\/BF02970142"},{"key":"bibr136-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1139\/o92-061"},{"key":"bibr137-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1159\/000111342"},{"key":"bibr138-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1054\/jocn.2001.0991"},{"key":"bibr139-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(95)02008-X"},{"key":"bibr140-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(99)01392-9"},{"key":"bibr141-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1038\/nm0498-447"},{"key":"bibr142-197140090601900406","doi-asserted-by":"publisher","DOI":"10.3109\/13506120308998993"},{"key":"bibr143-197140090601900406","doi-asserted-by":"publisher","DOI":"10.2174\/1381612033391649"},{"key":"bibr144-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-4310(00)01759-7"},{"key":"bibr145-197140090601900406","first-page":"55","volume":"4","author":"Xia W","year":"2003","journal-title":"Curr Opin Investig Drugs"},{"key":"bibr146-197140090601900406","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200216120-00003"},{"key":"bibr147-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2710.2002.00415.x"},{"key":"bibr148-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.10.4.593"},{"key":"bibr149-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(00)00147-0"},{"key":"bibr150-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02680.x"},{"key":"bibr151-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.01.020"},{"key":"bibr152-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5441.916"},{"key":"bibr153-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M311652200"},{"key":"bibr154-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.02234.x"},{"key":"bibr155-197140090601900406","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1124\/jpet.103.060715","volume":"309","author":"Lanz TA","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"bibr156-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C300019200"},{"key":"bibr157-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.048280"},{"key":"bibr158-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301619200"},{"key":"bibr159-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1038\/nrd938"},{"key":"bibr160-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1038\/nrn938"},{"key":"bibr161-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1038\/nm790"},{"key":"bibr162-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1038\/nm783"},{"key":"bibr163-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1038\/22124"},{"key":"bibr164-197140090601900406","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200317070-00001"},{"key":"bibr165-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00317-8"},{"key":"bibr166-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200010)48:4<567::AID-ANA3>3.0.CO;2-W"},{"key":"bibr167-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1038\/35050110"},{"key":"bibr168-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1038\/78682"},{"key":"bibr169-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.151261398"},{"key":"bibr170-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-09-03745.2003"},{"key":"bibr171-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2003.12.020"},{"key":"bibr172-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10876"},{"key":"bibr173-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1002\/bies.10236"},{"key":"bibr174-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1007\/s007020200044"},{"key":"bibr175-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(96)00115-7"},{"key":"bibr176-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1038\/35102591"},{"key":"bibr177-197140090601900406","doi-asserted-by":"crossref","unstructured":"Beher D, Clarke EE, Wrigley JD, Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma -secretase at a novel site-evidence for an allosteric mechanism. J Biol Chem 2004.","DOI":"10.1074\/jbc.M404937200"},{"key":"bibr178-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(01)00299-8"},{"key":"bibr179-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-06-02246.2002"},{"key":"bibr180-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2001.0422"},{"key":"bibr181-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.10.1439"},{"key":"bibr182-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03155-X"},{"key":"bibr183-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06384.x"},{"key":"bibr184-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2000.0304"},{"key":"bibr185-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.081620098"},{"key":"bibr186-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2001.0470"},{"key":"bibr187-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.33.23223"},{"key":"bibr188-197140090601900406","first-page":"777","volume":"46","author":"Atwood CS","year":"2000","journal-title":"Cell. Mol. Biol"},{"key":"bibr189-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1021\/bi990438f"},{"key":"bibr190-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.52.37111"},{"key":"bibr191-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1126\/science.8073293"},{"key":"bibr192-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(98)00092-6"},{"key":"bibr193-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00120-3"},{"key":"bibr194-197140090601900406","first-page":"57","volume-title":"Analytical Profiles of Drug Substances","author":"Padmanabhan G","year":"1989"},{"key":"bibr195-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.12.1685"},{"key":"bibr196-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92890-R"},{"key":"bibr197-197140090601900406","first-page":"203","volume":"13","author":"Scheltens PH","year":"2001","journal-title":"Aging"},{"key":"bibr198-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1159\/000017223"},{"key":"bibr199-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(98)00007-4"},{"key":"bibr200-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.03.040"},{"key":"bibr201-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.71.4.441"},{"key":"bibr202-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0404.107.s179.10.x"},{"key":"bibr203-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.07.003"},{"key":"bibr204-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1159\/000051258"},{"key":"bibr205-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(02)00026-5"},{"key":"bibr206-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(02)00002-9"},{"key":"bibr207-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200004)47:4<430::AID-ANA5>3.0.CO;2-I"},{"key":"bibr208-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.8.1188"},{"key":"bibr209-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2262011600"},{"key":"bibr210-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(02)00035-2"},{"key":"bibr211-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.6.928"},{"key":"bibr212-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.9.1760"},{"key":"bibr213-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610297004900"},{"key":"bibr214-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06730.x"},{"key":"bibr215-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)74869-8"},{"key":"bibr216-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(01)00271-8"},{"key":"bibr217-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.2001.3236"},{"key":"bibr218-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2004.03.011"},{"key":"bibr219-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1038\/386608a0"},{"key":"bibr220-197140090601900406","first-page":"1727","volume":"19","author":"Harris GJ","year":"1998","journal-title":"Am J Neuroradiol"},{"key":"bibr221-197140090601900406","first-page":"1030","volume":"22","author":"Bozzao A","year":"2001","journal-title":"Am J Neuroradiol"},{"key":"bibr222-197140090601900406","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200014060-00004"},{"key":"bibr223-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.5.684"},{"key":"bibr224-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(93)90249-D"},{"key":"bibr225-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-04-01460.1993"},{"key":"bibr226-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(97)00242-4"},{"key":"bibr227-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.8.1578"},{"key":"bibr228-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1007\/BF00230654"},{"key":"bibr229-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.154.10.1459"},{"key":"bibr230-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.70.836.9486060"},{"key":"bibr231-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.219.1.r01ap14101"},{"key":"bibr232-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.69.4.528"},{"key":"bibr233-197140090601900406","first-page":"661","volume":"41","author":"Phelps ME","year":"2000","journal-title":"J Nucl Med"},{"key":"bibr234-197140090601900406","first-page":"611","volume":"42","author":"Camargo EE","year":"2001","journal-title":"J Nucl Med"},{"key":"bibr235-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1053\/snuc.2003.127294"},{"key":"bibr236-197140090601900406","first-page":"391","volume":"35","author":"Salmon E","year":"1994","journal-title":"J Nucl Med"},{"key":"bibr237-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.9.1143"},{"key":"bibr238-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.9.1154"},{"key":"bibr239-197140090601900406","first-page":"71","volume":"40","author":"Silverman DH","year":"1999","journal-title":"J Nucl Med"},{"key":"bibr240-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1586\/14737159.4.1.63"},{"key":"bibr241-197140090601900406","first-page":"253","volume":"43","author":"Silverman DH","year":"2002","journal-title":"J Nucl Med"},{"key":"bibr242-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.17.2120"},{"key":"bibr243-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1997.01830150083012"},{"key":"bibr244-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2005.09.007"},{"key":"bibr245-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S1536-1632(02)00016-1"},{"key":"bibr246-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(95)11270-7"},{"key":"bibr247-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520360056039"},{"key":"bibr248-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-003-1194-1"},{"key":"bibr249-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.64.3.306"},{"key":"bibr250-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.69.5.661"},{"key":"bibr251-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1159\/000017250"},{"key":"bibr252-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.2.413"},{"key":"bibr253-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.5.643"},{"key":"bibr254-197140090601900406","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1017\/S1041610298005389","volume":"10","author":"Jobst KA","year":"1998","journal-title":"Int Psychogeriatr"},{"key":"bibr255-197140090601900406","first-page":"23","volume":"26","author":"McKelvey R","year":"1999","journal-title":"Can J Neurol Sci"},{"key":"bibr256-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.6.1563"},{"key":"bibr257-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.11.1545"},{"key":"bibr258-197140090601900406","first-page":"235","volume-title":"Neuronal Nicotinic Receptors: Pharmacology and Therapeutic Opportunities","author":"Villemagne VL","year":"1998"},{"key":"bibr259-197140090601900406","first-page":"165","volume":"376","author":"Nordberg A","year":"1991","journal-title":"Acta Radiol"},{"key":"bibr260-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)01112-4"},{"key":"bibr261-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0404.2000.00304.x"},{"key":"bibr262-197140090601900406","first-page":"1737","volume":"38","author":"Villemagne VL","year":"1997","journal-title":"J Nucl Med"},{"key":"bibr263-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(199708)26:4<392::AID-SYN7>3.0.CO;2-1"},{"key":"bibr264-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-8051(98)00101-2"},{"key":"bibr265-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb23022.x"},{"key":"bibr266-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(93)90138-G"},{"key":"bibr267-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-199809000-00017"},{"key":"bibr268-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1159\/000106611"},{"key":"bibr269-197140090601900406","first-page":"62","volume":"149","author":"Nordberg A","year":"1993","journal-title":"Acta Neurol Scand"},{"key":"bibr270-197140090601900406","first-page":"43","volume":"24","author":"Sedvall G","year":"1987","journal-title":"J Neural Transm"},{"key":"bibr271-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00230-X"},{"key":"bibr272-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1159\/000074679"},{"key":"bibr273-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.73.2.134"},{"key":"bibr274-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.2.205"},{"key":"bibr275-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510237103"},{"key":"bibr276-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00137-9"},{"key":"bibr277-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(96)05315-4"},{"key":"bibr278-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3956(97)00031-9"},{"key":"bibr279-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-0618(03)00002-4"},{"key":"bibr280-197140090601900406","doi-asserted-by":"crossref","unstructured":"Villemagne VL, Rowe CC, Macfarlane S, Imaginem Oblivionis: The prospects of neuroimaging for early detection of Alzheimer's disease. J Clin Neurosci, in press 2004.","DOI":"10.1016\/j.jocn.2004.03.011"},{"key":"bibr281-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-003-1034-9"},{"key":"bibr282-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10730"},{"key":"bibr283-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.24.14079"},{"key":"bibr284-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1038\/nn1422"},{"key":"bibr285-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2004.02.013"},{"key":"bibr286-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1738-05.2005"},{"key":"bibr287-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03436-4"},{"key":"bibr288-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-8051(03)00049-0"},{"key":"bibr289-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:20:1:15"},{"key":"bibr290-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(00)00237-2"},{"key":"bibr291-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/61.9.797"},{"key":"bibr292-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-8051(01)00264-5"},{"key":"bibr293-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1021\/jm010161t"},{"key":"bibr294-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-06-02086.2003"},{"key":"bibr295-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(01)01232-2"},{"key":"bibr296-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(01)00734-X"},{"key":"bibr297-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2034101100"},{"key":"bibr298-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.2580440110"},{"key":"bibr299-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1021\/jm030026b"},{"key":"bibr300-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20009"},{"key":"bibr301-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.13.7609"},{"key":"bibr302-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1021\/ja0167147"},{"key":"bibr303-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.716"},{"key":"bibr304-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2005.06.001"},{"key":"bibr305-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.08.004"},{"key":"bibr306-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00907-7"},{"key":"bibr307-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-24-j0004.2001"},{"key":"bibr308-197140090601900406","first-page":"S194","volume":"42","author":"Barrio JR","year":"1999","journal-title":"J Labelled Compd Radiopharm"},{"key":"bibr309-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1097\/00019442-200201000-00004"},{"key":"bibr310-197140090601900406","first-page":"65P","volume":"42","author":"Agdeppa ED","year":"2001","journal-title":"J Nucl Med"},{"key":"bibr311-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:19:3:321"},{"key":"bibr312-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00121-5"},{"key":"bibr313-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1021\/bc010066z"},{"key":"bibr314-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06358.x"},{"key":"bibr315-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199611040-00040"},{"key":"bibr316-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1021\/bc9901393"},{"key":"bibr317-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.22.10227"},{"key":"bibr318-197140090601900406","first-page":"2184","volume":"33","author":"Majocha RE","year":"1992","journal-title":"J Nucl Med"},{"key":"bibr319-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199407000-00009"},{"key":"bibr320-197140090601900406","first-page":"1044","volume":"43","author":"Shi J","year":"2002","journal-title":"J Nucl Med"},{"key":"bibr321-197140090601900406","first-page":"365","volume":"299","author":"Wadghiri YZ","year":"2005","journal-title":"Methods Mol Biol"},{"key":"bibr322-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20385"},{"key":"bibr323-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10529"},{"key":"bibr324-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-004-2442-x"},{"key":"bibr325-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.2.196"},{"key":"bibr326-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M501285200"},{"key":"bibr327-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M412056200"},{"key":"bibr328-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-005-1780-5"},{"key":"bibr329-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20009"},{"key":"bibr330-197140090601900406","first-page":"584","volume":"12","author":"Verhoeff NP","year":"2004","journal-title":"Am J Geriatr Psychiatry"},{"key":"bibr331-197140090601900406","doi-asserted-by":"crossref","unstructured":"Price JC, Klunk WE, Lopresti BJ, Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B. J Cereb Blood Flow Metab 2005.","DOI":"10.1038\/sj.jcbfm.9600146"},{"key":"bibr332-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2177-05.2005"},{"key":"bibr333-197140090601900406","first-page":"124P","volume":"46","author":"Villemagne VL","year":"2005","journal-title":"J Nucl Med"},{"key":"bibr334-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199903)45:3<358::AID-ANA12>3.0.CO;2-X"},{"key":"bibr335-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199812000-00009"},{"key":"bibr336-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:17:2:101"},{"key":"bibr337-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.3.397"},{"key":"bibr338-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610297004973"},{"key":"bibr339-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.12.1791"},{"key":"bibr340-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2153(05)70008-9"},{"key":"bibr341-197140090601900406","doi-asserted-by":"crossref","unstructured":"Nichols L, Pike VW, Cai L, Imaging and In Vivo Quantitation of beta-Amyloid: An Exemplary Biomarker for Alzheimer's Disease? Biol Psychiatry 2006.","DOI":"10.1016\/j.biopsych.2005.12.004"},{"key":"bibr342-197140090601900406","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2004.07.012"},{"key":"bibr343-197140090601900406","first-page":"146","volume":"64","author":"Alzheimer A","year":"1907","journal-title":"Allg Z Psychiatr"}],"container-title":["The Neuroradiology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/197140090601900406","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/197140090601900406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:24:21Z","timestamp":1777587861000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/197140090601900406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":343,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1177\/197140090601900406"],"URL":"https:\/\/doi.org\/10.1177\/197140090601900406","relation":{},"ISSN":["1971-4009","2385-1996"],"issn-type":[{"value":"1971-4009","type":"print"},{"value":"2385-1996","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8]]}}}