{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:38:30Z","timestamp":1777876710396,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neuroradiol J"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>The aim of this study was to explore whether intellectual performance in children with Sickle Cell Disease and with low risk of stroke as determined with conventional transcranial Doppler ultrasonography (TCD) criteria was associated with hemodynamic parameters in imaging TCD, when controlling for hematological and socio-economical variables and presence of silent infarcts. We performed neuropsychological testing with Kaufman Brief Intelligence Test (K-BIT-IQ) and imaging TCD examinations to measure blood flow velocities and pulsatility indexes (PI) in the middle cerebral arteries (MCA) In 46 children with homozygous HbSS (mean age 108\u00b134 months, range limits: 47\u2013166 months; 24 females), without a history of stroke or transient ischemic attack, with no stenosis on magnetic resonance angiography and with velocities below 170 cm\/s in screening conventional TCD. Mean K-BIT IQ Composite and Vocabulary scores (91\u00b113 and 86\u00b114 respectively) were significantly below the average scores of 100 for the age-matched population (one sample t-test=5.21, p&lt;0.001). Using univariate and multivariate regression models, we found that lower PI in the right MCA was associated with lower K-BIT-IQ Composite and Vocabulary scores. Furthermore, we found that interhemispheric differences in PIs were even more strongly associated with neuropsychological performance, whereas flow velocities were not associated with the K-BIT-IQ score. Using a model of chronic anemia, we found that cognitive functioning was associated with cerebral hemodynamics.<\/jats:p>","DOI":"10.1177\/197140091202500311","type":"journal-article","created":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T17:40:15Z","timestamp":1429724415000},"page":"351-359","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of Pulsatility Index in the Middle Cerebral Artery with Intelligence Quotient in Children with Sickle Cell Disease"],"prefix":"10.1177","volume":"25","author":[{"given":"J.","family":"Krejza","sequence":"first","affiliation":[{"name":"Department of Radiology, Division of Neuroradiology, University of Pennsylvania; Philadelphia, PA, USA"},{"name":"Department of Nuclear Medicine, Medical University of Gdansk; Gdansk, Poland"},{"name":"Al-Imam Muhammad Ibn Saud Islamic University; Riyadh, Saudi 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