{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:48:25Z","timestamp":1793832505826,"version":"4.6.1"},"reference-count":36,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neuroradiol J"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The diagnosis of intracranial tuberculomas is often challenging. Our purpose is to describe the most common metabolic patterns of tuberculomas by MR spectroscopy (MRS) with emphasis on potential specific markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Single-voxel MRS short echo time was performed in 13 cases of tuberculomas proven by histology and\/or response to anti-mycobacterial therapy. For comparison MRS was also performed in 19 biopsy-proven malignant tumors (13 high-grade gliomas and six metastasis). Presence of metabolic peaks was assessed visually and categorical variables between groups were compared using chi-square. Metabolite ratios were compared using Mann-Whitney test and diagnostic accuracy of the metabolite ratios was compared using receiver-operating characteristic (ROC) curves analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Spectroscopic peaks representing lipids and glutamate\/glutamine (Glx) as well as a peak at \u223c3.8\u2009ppm were well defined in 77% (10\/13), 77% (10\/13) and 69% (nine of 13) of tuberculomas, respectively. Lipid and Glx peaks were also present in most of the malignant lesions, 79% (15\/19) and 74% (14\/19) respectively. However, a peak at \u223c3.8\u2009ppm was present in only 10% (two of 19) of the tumor cases ( p\u2009&lt;\u20090.001). Higher Cho\/Cr and mI\/Cr ratios helped discriminate malignant lesions with an area under the ROC curve of 0.86 (SE: 0.078, p\u2009&lt;\u20090.002, CI: 0.7\u20131) and 0.8 (SE: 0.1, p\u2009&lt;\u20090.009, CI: 0.6\u20131), respectively. Threshold values between 1.7\u20131.9 for Cho\/Cr and 0.8\u20130.9 for mI\/Cr provided high specificity (91% for both metabolites) and adequate sensitivity (75% and 80%, respectively) for discrimination of malignant lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A singlet peak at \u223c3.8\u2009ppm is present in the majority of tuberculomas and absent in most malignant tumors, potentially a marker to differentiate these lesions. The assignment of the peak is difficult from our analysis; however, guanidinoacetate (Gua) is a possibility. Higher Cho\/Cr and mI\/Cr ratios should favor malignant lesions over tuberculomas. The presence of lipids and Glx is non-specific.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1971400915592077","type":"journal-article","created":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T04:53:27Z","timestamp":1438750407000},"page":"294-302","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["MR spectroscopy of intracranial tuberculomas: A singlet peak at 3.8\u2009ppm as potential marker to differentiate them from malignant tumors"],"prefix":"10.1177","volume":"28","author":[{"given":"Humberto","family":"Morales","sequence":"first","affiliation":[{"name":"Section of Neuroradiology, Department of Radiology, University of Cincinnati Medical Center, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Alfaro","sequence":"additional","affiliation":[{"name":"Centro de Resonancia Magnetica (CEREMA), Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Martinot","sequence":"additional","affiliation":[{"name":"Centro de Resonancia Magnetica (CEREMA), Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Fayed","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hospital Quiron, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Gaskill-Shipley","sequence":"additional","affiliation":[{"name":"Section of Neuroradiology, Department of Radiology, University of Cincinnati Medical Center, 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