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When large in size, the airway may become obstructed, and when accompanied by suspicious features such as cartilaginous invasion, extension to the pre-epiglottic or para-glottic spaces, or lymphadenopathy, the radiologist must consider malignancy as a primary differential diagnosis. However, when only benign features are identified, the differential diagnosis is broad. We present a 65-year-old female with an incidental 1\u2009cm exophytic, pedunculated, papillomatous lesion on the laryngeal surface of the epiglottis discovered upon endoscopic evaluation for dyspepsia and heartburn. Because of her risk factors for malignancy, CT scan was requested and revealed only benign features. Subsequent excisional biopsy revealed a benign squamous papilloma; however, multiple additional differential considerations were entertained preoperatively.<\/jats:p>","DOI":"10.1177\/1971400915594517","type":"journal-article","created":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T04:53:27Z","timestamp":1438750407000},"page":"347-353","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Epiglottic masses identified on CT imaging: A case report and review of the broad differential diagnosis"],"prefix":"10.1177","volume":"28","author":[{"given":"Jonathan","family":"Tresley","sequence":"first","affiliation":[{"name":"Department of Diagnostic Radiology, Jackson Memorial Hospital; Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efrat","family":"Saraf-Lavi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Jackson Memorial Hospital; Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleksandr","family":"Kryvenko","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Urology, University of Miami Miller School of Medicine; Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoukaa","family":"Sargi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, University of Miami Miller School of Medicine; Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,8,5]]},"reference":[{"key":"bibr1-1971400915594517","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.890924"},{"key":"bibr2-1971400915594517","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.11.2008.1228"},{"key":"bibr3-1971400915594517","doi-asserted-by":"publisher","DOI":"10.1080\/00016480510029392"},{"key":"bibr4-1971400915594517","doi-asserted-by":"publisher","DOI":"10.1177\/000348948509400512"},{"key":"bibr5-1971400915594517","first-page":"73","volume":"58","author":"Mesolella M","year":"2004","journal-title":"Acta Otorhinolaryngol Belg"},{"key":"bibr6-1971400915594517","doi-asserted-by":"publisher","DOI":"10.1016\/0899-7071(94)00055-H"},{"key":"bibr7-1971400915594517","unstructured":"Referral guidelines for suspected cancer in adults and children. 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