{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:40:06Z","timestamp":1777876806630,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T00:00:00Z","timestamp":1479859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neuroradiol J"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>To determine the optimal time window for MR imaging with quantitative ADC measurement in neonatal HIE after hypothermia treatment, a retrospective review was performed on consecutive hypothermia-treated term neonates with HIE, with an initial and follow-up MR imaging within the first two weeks of life. Three neuroradiologists categorized each set of MR imaging as normal, mild, moderate or severe HIE based on a consensus review of the serial imaging. The lowest ADC values from the white matter, corpus callosum, and basal ganglia\/thalamus were measured. The ADC values between mild-moderate and severe HIE were compared using a Student\u2019s t-test over a range of different time windows. A total of 33 MR imaging examinations were performed on 16 neonates that included three normal, four mild, five moderate, and four severe HIE. The time window of 3\u201310 days showed a statistically significant decrease in ADC value in severe HIE compared to mild-moderate HIE in all three locations, respectively: white matter 0.5\u2009\u00b1\u20090.22 versus 0.83\u2009\u00b1\u20090.27 ( p value 0.01), corpus callosum 0.69\u2009\u00b1\u20090.19 versus 0.91\u2009\u00b1\u20090.17 ( p value 0.01), and basal ganglia\/thalamus 0.63\u2009\u00b1\u20090.16 versus 0.98\u2009\u00b1\u20090.06 ( p value &lt;0.01). The range of 3\u201310 days is the optimal time window for MR imaging with quantitative ADC after hypothermia treatment.<\/jats:p>","DOI":"10.1177\/1971400916678229","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T21:20:30Z","timestamp":1479936030000},"page":"28-35","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Hypothermia-treated neonates with hypoxic-ischemic encephalopathy: Optimal timing of quantitative ADC measurement to predict disease severity"],"prefix":"10.1177","volume":"30","author":[{"given":"Yauk K","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Radiology, Santa Clara Valley Medical Center, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Penn","sequence":"additional","affiliation":[{"name":"Department of Radiology, Santa Clara Valley Medical Center, 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