{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:32:26Z","timestamp":1783031546113,"version":"3.54.6"},"reference-count":16,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neuroradiol J"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>Ependymal tumours in adults are rare, accounting for less than 4% of primary tumours of the central nervous system, and exceptionally metastasise outside the nervous system. In this study, we present a case of anaplastic ependymoma, which developed metastases outside the nervous system less than a year after its clinical onset. A healthy 65-year-old woman suddenly presented with drowsiness of unknown origin, accompanied by ingravescent fatigue, inability to maintain the upright posture, headache, nausea and vomiting. Computed tomography study performed in the emergency department showed the presence of an inhomogeneously hypodense area, with temporoparietal extension and median line deviation. After surgical excision, performed after two days, the bioptic examination demonstrated an anaplastic ependymoma with multiple areas of necrosis. The patient was submitted to adjuvant radiation therapy. At magnetic resonance imaging follow-up, performed three months after surgery, neither local recurrences nor typical \u2018drop metastases\u2019 to the spinal area were observed. Three months later, magnetic resonance imaging control revealed bone metastases and recurrences in the left insula and at the ipsilateral cerebellar hemisphere. Total body computed tomography examination showed metastases in the liver, vertebrae and pelvic bones, and involvement of paratracheal lymph nodes.<\/jats:p>","DOI":"10.1177\/1971400916689371","type":"journal-article","created":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T06:08:00Z","timestamp":1487570880000},"page":"274-280","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Systemic metastases from central nervous system ependymoma: case report and review of the literature"],"prefix":"10.1177","volume":"30","author":[{"given":"Claudia","family":"Marsecano","sequence":"first","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Science, Division of Radiology, University of L'Aquila, L'Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Bruno","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Science, Division of Radiology, University of L'Aquila, L'Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Michelini","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Science, Division of Radiology, University of L'Aquila, L'Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Perri","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Science, Division of Radiology, University of L'Aquila, L'Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Calvisi","sequence":"additional","affiliation":[{"name":"Department of Pathology, S. Salvatore Hospital L'Aquila, L'Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Di Cesare","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Science, Division of Radiology, University of L'Aquila, L'Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Splendiani","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Science, Division of Radiology, University of L'Aquila, L'Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,1,1]]},"reference":[{"key":"bibr1-1971400916689371","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/not151"},{"key":"bibr2-1971400916689371","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-010-0109-3"},{"key":"bibr3-1971400916689371","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nou162"},{"key":"bibr4-1971400916689371","volume-title":"WHO Classification of Tumours of the Central Nervous System, Revised","author":"Louis DN","year":"2016","edition":"4"},{"key":"bibr5-1971400916689371","first-page":"362","volume-title":"Manuale di RM in Neuroradiologia","author":"Andreula C","year":"2009"},{"key":"bibr6-1971400916689371","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.34689"},{"key":"bibr7-1971400916689371","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2014.09.006"},{"key":"bibr8-1971400916689371","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2015.11.061"},{"key":"bibr9-1971400916689371","first-page":"PC12","volume":"10","author":"Balasubramaniam S","year":"2016","journal-title":"J Clin Diagn Res"},{"key":"bibr10-1971400916689371","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24268"},{"key":"bibr11-1971400916689371","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2009.09.003"},{"key":"bibr12-1971400916689371","volume-title":"WHO classification of tumours of the central nervous system","author":"Louis DN","year":"2007"},{"key":"bibr13-1971400916689371","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2015.04.002"},{"key":"bibr14-1971400916689371","doi-asserted-by":"publisher","DOI":"10.15274\/NRJ-2014-10087"},{"key":"bibr15-1971400916689371","doi-asserted-by":"publisher","DOI":"10.1177\/197140091202500608"},{"key":"bibr16-1971400916689371","doi-asserted-by":"publisher","DOI":"10.1177\/197140091202500611"}],"container-title":["The Neuroradiology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1971400916689371","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1971400916689371","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1971400916689371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:33:30Z","timestamp":1777588410000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1971400916689371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,1]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1177\/1971400916689371"],"URL":"https:\/\/doi.org\/10.1177\/1971400916689371","relation":{},"ISSN":["1971-4009","2385-1996"],"issn-type":[{"value":"1971-4009","type":"print"},{"value":"2385-1996","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,1]]}}}