{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:40:32Z","timestamp":1777876832712,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T00:00:00Z","timestamp":1499904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS085381"],"award-info":[{"award-number":["R01 NS085381"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neuroradiol J"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>We compared fractional anisotropy and radial diffusivity measurements between pediatric canines affected with mucopolysaccharidosis I and pediatric control canines. We hypothesized that lower fractional anisotropy and higher radial diffusivity values, consistent with dysmyelination, would be present in the mucopolysaccharidosis I cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Six canine brains, three affected with mucopolysaccharidosis I and three unaffected, were euthanized at 7 weeks and imaged using a 7T small-animal magnetic resonance imaging system. Average fractional anisotropy and radial diffusivity values were calculated for four white-matter regions based on 100 regions of interest per region per specimen. A 95% confidence interval was calculated for each mean value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No difference was seen in fractional anisotropy or radial diffusivity values between mucopolysaccharidosis affected and unaffected brains in any region. In particular, the 95% confidence intervals for mucopolysaccharidosis affected and unaffected canines frequently overlapped for both fractional anisotropy and radial diffusivity measurements. In addition, in some brain regions a large range of fractional anisotropy and radial diffusivity values were seen within the same cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The fractional anisotropy and radial diffusivity values of white matter did not differ between pediatric mucopolysaccharidosis affected canines and pediatric control canines. Possible explanations include: (a) a lack of white matter tissue differences between mucopolysaccharidosis affected and unaffected brains at early disease stages; (b) diffusion tensor imaging does not detect any existing differences; (c) inflammatory processes such as astrogliosis produce changes that offset the decreased fractional anisotropy values and increased radial diffusivity values that are expected in dysmyelination; and (d) our sample size was insufficient to detect differences. Further studies correlating diffusion tensor imaging findings to histology are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1971400917718844","type":"journal-article","created":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T09:02:03Z","timestamp":1505466123000},"page":"454-460","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative diffusion tensor imaging analysis does not distinguish pediatric canines with mucopolysaccharidosis I from control canines"],"prefix":"10.1177","volume":"30","author":[{"given":"Dana M","family":"Middleton","sequence":"first","affiliation":[{"name":"Duke University School of Medicine, Durham, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan Y","family":"Li","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine, Durham, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven D","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Duke University Medical Center, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard E","family":"White","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Duke University Medical Center, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia I","family":"Dickson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor \u2013 UCLA Medical Center, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Matthew Ellinwood","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M","family":"Provenzale","sequence":"additional","affiliation":[{"name":"Department of Radiology, Duke University Medical Center, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,7,13]]},"reference":[{"key":"bibr1-1971400917718844","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.782"},{"key":"bibr2-1971400917718844","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1267"},{"key":"bibr3-1971400917718844","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.10.6382"},{"key":"bibr4-1971400917718844","doi-asserted-by":"publisher","DOI":"10.1097\/01.rmr.0000248665.84211.0f"},{"key":"bibr5-1971400917718844","first-page":"163","volume":"63","author":"Vite C","year":"2013","journal-title":"Comp 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