{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:40:38Z","timestamp":1777876838163,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:00:00Z","timestamp":1516320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH-F32NS093898"],"award-info":[{"award-number":["NIH-F32NS093898"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH-P40-OD-010939"],"award-info":[{"award-number":["NIH-P40-OD-010939"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH-R01-NS085381"],"award-info":[{"award-number":["NIH-R01-NS085381"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH-R01-NS-096087"],"award-info":[{"award-number":["NIH-R01-NS-096087"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neuroradiol J"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The purpose of this study was to compare quantitative diffusion tensor imaging metrics in dogs affected with a model of Krabbe disease to age-matched normal controls. We hypothesized that fractional anisotropy would be decreased and radial diffusivity would be increased in the Krabbe dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used a highly reproducible region-of-interest interrogation technique to measure fractional anisotropy and radial diffusivity in three different white matter regions within the internal capsule and centrum semiovale in four Krabbe affected brains and three age-matched normal control brains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Despite all four Krabbe dogs manifesting pelvic limb paralysis at the time of death, age-dependent differences in DTI metrics were observed. In the 9, 12, and 14 week old Krabbe dogs, FA values unexpectedly increased and RD values decreased. FA values were generally higher and RD values generally lower in both regions of the internal capsule in the Krabbe brains during this period. FA values in the brain from the 16 week old Krabbe dog decreased and were lower than in control brains and RD values increased and were higher than in control brain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that FA and RD in the internal capsule and centrum semiovale are affected differently at different ages, despite disease having progressed to pelvic limb paralysis in all dogs evaluated. In 9, 12, and 14 week old Krabbe dogs, higher FA values and lower RD values are seen in the internal capsule. However, in the 16 week old Krabbe dog, lower FA and higher RD values are seen, consistent with previous observations in Krabbe dogs, as well as observations in human Krabbe patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1971400917733431","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T06:33:56Z","timestamp":1516343636000},"page":"168-176","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Quantitative DTI metrics in a canine model of Krabbe disease: comparisons versus age-matched controls across multiple ages"],"prefix":"10.1177","volume":"31","author":[{"given":"Jonathan Y","family":"Li","sequence":"first","affiliation":[{"name":"School of Medicine, Duke University, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana M","family":"Middleton","sequence":"additional","affiliation":[{"name":"School of Medicine, Duke University, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Duke University Medical Center, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard","family":"White","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Duke University, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carley R","family":"Corado","sequence":"additional","affiliation":[{"name":"BioMarin Pharmaceutical Inc., Novato, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Vite","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Bradbury","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M","family":"Provenzale","sequence":"additional","affiliation":[{"name":"Department of Radiology, Duke University Medical Center, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,1,19]]},"reference":[{"key":"bibr1-1971400917733431","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.782"},{"key":"bibr2-1971400917733431","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910360419"},{"key":"bibr3-1971400917733431","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1051"},{"key":"bibr4-1971400917733431","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1267"},{"key":"bibr5-1971400917733431","doi-asserted-by":"publisher","DOI":"10.1177\/197140091302600502"},{"key":"bibr6-1971400917733431","doi-asserted-by":"publisher","DOI":"10.15274\/nrj-2014-10110"},{"key":"bibr7-1971400917733431","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.06.067"},{"key":"bibr8-1971400917733431","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2013.04.003"},{"key":"bibr9-1971400917733431","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2010.01785.x"},{"key":"bibr10-1971400917733431","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2005.tb00281.x"},{"key":"bibr11-1971400917733431","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01582-09"},{"key":"bibr12-1971400917733431","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.02.017"},{"key":"bibr13-1971400917733431","doi-asserted-by":"publisher","DOI":"10.1016\/j.repbio.2013.12.007"},{"key":"bibr14-1971400917733431","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2006.12.012"},{"key":"bibr15-1971400917733431","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2013.10.001"},{"key":"bibr16-1971400917733431","doi-asserted-by":"publisher","DOI":"10.1093\/jhered\/90.1.138"},{"key":"bibr17-1971400917733431","doi-asserted-by":"publisher","DOI":"10.1177\/1971400916665378"},{"key":"bibr18-1971400917733431","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1996.0220"},{"key":"bibr19-1971400917733431","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2010.01782.x"},{"key":"bibr20-1971400917733431","doi-asserted-by":"publisher","DOI":"10.1177\/1971400917709629"},{"key":"bibr21-1971400917733431","doi-asserted-by":"publisher","DOI":"10.1177\/1971400917715792"},{"key":"bibr22-1971400917733431","doi-asserted-by":"publisher","DOI":"10.1177\/1971400915609351"},{"key":"bibr28-1971400917733431","doi-asserted-by":"crossref","unstructured":"Poretti A, et al. Novel diffusion tensor imaging findings in Krabbe disease.\n                      Eur J Paediatr Neurol\n                      2014; 18(2): 150\u2013156.","DOI":"10.1016\/j.ejpn.2013.09.008"},{"key":"bibr29-1971400917733431","doi-asserted-by":"crossref","unstructured":"Escolar ML, et al. Diffusion tensor imaging detects abnormalities in the corticospinal tracts of neonates with infantile Krabbe disease.\n                      AJNR Am J Neuroradiol\n                      2009; 30(5): 1017\u20131021.","DOI":"10.3174\/ajnr.A1476"},{"key":"bibr23-1971400917733431","doi-asserted-by":"publisher","DOI":"10.1159\/000373885"},{"key":"bibr24-1971400917733431","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1998.tb03741.x"},{"key":"bibr25-1971400917733431","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3181e3de90"},{"key":"bibr26-1971400917733431","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20774"},{"key":"bibr27-1971400917733431","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu298"}],"container-title":["The Neuroradiology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1971400917733431","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1971400917733431","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1971400917733431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:34:11Z","timestamp":1777588451000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1971400917733431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,19]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1177\/1971400917733431"],"URL":"https:\/\/doi.org\/10.1177\/1971400917733431","relation":{},"ISSN":["1971-4009","2385-1996"],"issn-type":[{"value":"1971-4009","type":"print"},{"value":"2385-1996","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,19]]}}}