{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:41:07Z","timestamp":1777876867482,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T00:00:00Z","timestamp":1559260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neuroradiol J"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The use of susceptibility weighted imaging in high field magnetic resonance imaging scanners can detect the nigrosome-1 area located in the caudo-lateral region of the pars compacta in the substantia nigra. This structure comprises a significant amount of dopaminergic neurons and degenerates in the early stages of Parkinson\u2019s disease. Essential tremor is a neurological condition that in some cases could be confused with the early stages of Parkinson\u2019s disease with a possible error in clinical diagnosis. Our purpose is to evaluate the accuracy of nigrosome-1 detection by high resolution magnetic resonance imaging to discriminate Parkinson\u2019s disease from essential tremor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A case\u2013control study compared patients with a clinical diagnosis of Parkinson\u2019s disease and essential tremor. Magnetic resonance imaging studies were performed using a 3T magnetic resonance imaging scanner. The susceptibility weighted imaging sequence was obtained in the axial plane with an isotropic voxel of 0.75\u2009mm. Two independent neuroradiologists evaluated the images without access to clinical patient data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixteen patients were included in each group (Parkinson\u2019s disease and essential tremor). Average age: Parkinson\u2019s disease group: 71.3 (SD 6.3) and essential tremor group: 68.3 (SD 12.3). For the first evaluator, the nigrosome-1 area was absent in 15 patients with Parkinson\u2019s disease and in two with essential tremor and for the second evaluator was absent in 15 patients with Parkinson\u2019s disease and four with essential tremor. The sensitivity\/specificity for the diagnosis of Parkinson\u2019s disease was 93.75%\/87.5% for the first evaluator and 93.75%\/75% for the second evaluator.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The detection of the nigrosome-1 area is a useful tool in the differential diagnosis between Parkinson\u2019s disease and essential tremor, with high sensitivity and specificity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1971400919853787","type":"journal-article","created":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T09:34:17Z","timestamp":1559295257000},"page":"395-400","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Accuracy of nigrosome-1 detection to discriminate patients with Parkinson\u2019s disease and essential tremor"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5144-6462","authenticated-orcid":false,"given":"Manuel S","family":"Perez Akly","sequence":"first","affiliation":[{"name":"Department of Diagnostic Imaging, Hospital Italiano de Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla V","family":"Stefani","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Italiano de Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc\u00eda","family":"Ciancaglini","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Italiano de Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 S","family":"Bestoso","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Italiano de Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge A","family":"Funes","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Hospital Italiano de Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego J","family":"Bauso","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Italiano de Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina H","family":"Besada","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Hospital Italiano de Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,5,31]]},"reference":[{"key":"bibr1-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"bibr2-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf080"},{"key":"bibr3-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.73.5.529"},{"key":"bibr4-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/28.2.99"},{"key":"bibr5-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-013-0378-8"},{"key":"bibr6-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp010928"},{"key":"bibr7-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870131303"},{"key":"bibr8-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26265"},{"key":"bibr9-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.12.2143"},{"key":"bibr10-1971400919853787","doi-asserted-by":"crossref","unstructured":"Pan P, Zhang Y, Liu Y, et\u00a0al. Abnormalities of regional brain function in Parkinson\u2019s disease: a meta-analysis of resting state functional magnetic resonance imaging studies.\n                      Sci Rep\n                      . Epub ahead of print 1 December 2017. DOI: 10.1038\/srep40469.","DOI":"10.1038\/srep40469"},{"key":"bibr11-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000340982.01727.6e"},{"key":"bibr12-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31829e6fd2"},{"key":"bibr13-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.8.1421"},{"key":"bibr14-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.8.1437"},{"key":"bibr15-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093814"},{"key":"bibr16-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1991.tb08170.x"},{"key":"bibr17-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410320717"},{"key":"bibr18-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26171"},{"key":"bibr19-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26584"},{"key":"bibr20-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2017.12.021"},{"key":"bibr21-1971400919853787","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4158"},{"key":"bibr22-1971400919853787","doi-asserted-by":"publisher","DOI":"10.12659\/PJR.897090"},{"key":"bibr23-1971400919853787","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4412"},{"key":"bibr24-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0404.2002.1o040.x"},{"key":"bibr25-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2006.05.033"},{"key":"bibr26-1971400919853787","doi-asserted-by":"crossref","unstructured":"Romero JP, Benito-Leon J and Bermejo-Pareja F. The NEDICES study: recent advances in the understanding of the epidemiology of essential tremor.\n                      Tremor Other Hyperkinetic Movements (New York, NY)\n                      2012; 2: tre-02-70-346-2.","DOI":"10.5334\/tohm.117"},{"key":"bibr27-1971400919853787","first-page":"313","volume":"45","author":"Lang AE","year":"1987","journal-title":"Adv Neurol"},{"key":"bibr28-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410350613"},{"key":"bibr29-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2015.09.032"},{"key":"bibr30-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.3.354"},{"key":"bibr31-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.147223"},{"key":"bibr32-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0b013e3282f4d307"},{"key":"bibr33-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26515"},{"key":"bibr34-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm266"},{"key":"bibr35-1971400919853787","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26708"}],"container-title":["The Neuroradiology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1971400919853787","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1971400919853787","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1971400919853787","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:34:59Z","timestamp":1777588499000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1971400919853787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,31]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1177\/1971400919853787"],"URL":"https:\/\/doi.org\/10.1177\/1971400919853787","relation":{},"ISSN":["1971-4009","2385-1996"],"issn-type":[{"value":"1971-4009","type":"print"},{"value":"2385-1996","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,31]]}}}