{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:07:16Z","timestamp":1787162836855,"version":"build-2736575974"},"reference-count":80,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T00:00:00Z","timestamp":1560902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neuroradiol J"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>The aims of this work were to evaluate whether the treatment of patients with fibromyalgia with memantine is associated with significant changes in metabolite concentrations in the brain, and to explore any changes in clinical outcome measures. Magnetic resonance spectroscopy was performed of the right anterior and posterior insula, both hippocampi and the posterior cingulate cortex. Questionnaires on pain, anxiety, depression, global function, quality of life and cognitive impairment were used. Ten patients were studied at baseline and after three months of treatment with memantine. Significant increases were observed in the following areas: N-acetylaspartate (4.47 at baseline vs. 4.71 at three months, p\u2009=\u20090.02) and N-acetylaspartate+N-acetylaspartate glutamate in the left hippocampus (5.89 vs. 5.98; p\u2009=\u20090.007); N-acetylaspartate+N-acetylaspartate glutamate in the right hippocampus (5.31 vs 5.79; p\u2009=\u20090.01) and the anterior insula (7.56 vs. 7.70; p\u2009=\u20090.033); glutamate+glutamine\/creatine ratio in the anterior insula (2.03 vs. 2.17; p\u2009=\u20090.022) and the posterior insula (1.77 vs. 2.00; p\u2009=\u20090.004); choline\/creatine ratio in the posterior cingulate (0.18 vs. 0.19; p\u2009=\u20090.023); and creatine in the right hippocampus (3.60 vs. 3.85; p\u2009=\u20090.007). At the three-month follow-up, memantine improved cognitive function assessed by the Cognition Mini-Exam (31.50, SD\u2009=\u20092.95 vs. 34.40, SD\u2009=\u20090.6; p\u2009=\u20090.005), depression measured by the Hamilton Depression Scale (7.70, SD\u2009=\u20090.81 vs. 7.56, SD\u2009=\u20090.68; p\u2009=\u20090.042) and severity of illness measured by the Clinical Global Impression severity scale (5.79, SD\u2009=\u20090.96 vs. 5.31, SD\u2009=\u20091.12; p\u2009=\u20090.007). Depression, clinical global impression and cognitive function showed improvement with memantine. Magnetic resonance spectroscopy could be useful in monitoring response to the pharmacological treatment of fibromyalgia.<\/jats:p>","DOI":"10.1177\/1971400919857544","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T08:18:04Z","timestamp":1560932284000},"page":"408-419","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Changes in metabolites in the brain of patients with fibromyalgia after treatment with an NMDA receptor antagonist"],"prefix":"10.1177","volume":"32","author":[{"given":"Nicolas","family":"Fayed","sequence":"first","affiliation":[{"name":"Department of Radiology, Quir\u00f3nsalud Hospital, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Oliv\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Psychology and Sociology, University of Zaragoza, Spain"},{"name":"Preventative Activities and Health Promotion Network (REDIAPP) (G06\/170)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Lopez del Hoyo","sequence":"additional","affiliation":[{"name":"Department of Psychology and Sociology, University of Zaragoza, Spain"},{"name":"Preventative Activities and Health Promotion Network (REDIAPP) (G06\/170)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Andr\u00e9s","sequence":"additional","affiliation":[{"name":"CIBER Epidemiology and Public Health, Clinical Epidemiology Unit, October 12 Hospital, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari Cruz","family":"Perez-Yus","sequence":"additional","affiliation":[{"name":"Preventative Activities and Health Promotion Network (REDIAPP) (G06\/170)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Fayed","sequence":"additional","affiliation":[{"name":"Department of Neurorehabilitation, San Juan de Dios Hospital, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa F","family":"Angel","sequence":"additional","affiliation":[{"name":"Department of Radiology, Quir\u00f3nsalud Hospital, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Serrano-Blanco","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Parc Sanitari St. Joan of God and the St. Joan of God Foundation, Spain"},{"name":"Preventative Activities and Health Promotion Network (REDIAPP) (G06\/170)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miquel","family":"Roca","sequence":"additional","affiliation":[{"name":"Health Sciences Research University Institute, Juan March Hospital, Illes Balears University, Spain"},{"name":"Preventative Activities and Health Promotion Network (REDIAPP) (G06\/170)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3797-4218","authenticated-orcid":false,"given":"Javier","family":"Garcia Campayo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Miguel Servet Hospital and the University of Zaragoza. 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