{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:46:56Z","timestamp":1789706816563,"version":"4.0.1"},"reference-count":16,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T00:00:00Z","timestamp":1589328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neuroradiol J"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p>A 56-year-old woman with a history of diffuse large B-cell non-Hodgkin lymphoma (DLBCL-NHL) in remission for two years presented with weight loss and multifocal sensory\/motor symptoms. Magnetic resonance imaging (MRI) of the neuraxis and whole-body FDG PET\/CT led to a diagnosis of secondary neurolymphomatosis (NL). MRI demonstrated extensive thickening and enhancement of multiple cranial nerves and peripheral nerve plexuses with corresponding elevated metabolism on FDG PET\/CT. Treatment with chemotherapy resulted in complete response on FDG PET\/CT and subsequently she underwent autologous stem cell transplantation. NL is a rare manifestation of lymphoma affecting the peripheral nervous system. Nonspecific neuropathic symptoms make clinical diagnosis difficult. Though nerve biopsy is considered the gold standard, MRI and FDG PET\/CT are accepted alternatives for making the diagnosis. We review imaging findings in NL, describe the differential diagnosis, and discuss the limitations of the imaging modalities.<\/jats:p>","DOI":"10.1177\/1971400920924799","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T14:06:26Z","timestamp":1589378786000},"page":"230-235","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Diffuse large B-cell lymphoma relapse presenting as extensive neurolymphomatosis"],"prefix":"10.1177","volume":"33","author":[{"given":"Pankaj","family":"Nepal","sequence":"first","affiliation":[{"name":"Department of Radiology and Medical Imaging, St. Vincent\u2019s Medical Center, Bridgeport, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3744-7012","authenticated-orcid":false,"given":"Prem P","family":"Batchala","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice K","family":"Rehm","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilo E","family":"Fadul","sequence":"additional","affiliation":[{"name":"Division of Neuro-oncology, Department of Neurology, University of Virginia Health System, Charlottesville, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,5,13]]},"reference":[{"key":"bibr1-1971400920924799","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-12-258210"},{"key":"bibr2-1971400920924799","doi-asserted-by":"publisher","DOI":"10.1111\/1754-9485.12321"},{"key":"bibr3-1971400920924799","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nly055"},{"key":"bibr4-1971400920924799","first-page":"104","volume":"5","author":"Baehring JM","year":"2003","journal-title":"Oncol"},{"key":"bibr5-1971400920924799","first-page":"887","volume":"81","author":"Azhary H","year":"2010","journal-title":"Am Fam Physician"},{"key":"bibr6-1971400920924799","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12295"},{"key":"bibr7-1971400920924799","doi-asserted-by":"publisher","DOI":"10.1177\/014107689408700915"},{"key":"bibr8-1971400920924799","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0b013e3283561881"},{"key":"bibr9-1971400920924799","doi-asserted-by":"publisher","DOI":"10.1148\/rg.347130129"},{"key":"bibr10-1971400920924799","doi-asserted-by":"publisher","DOI":"10.1007\/s13139-010-0070-8"},{"key":"bibr11-1971400920924799","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2016.11.006"},{"key":"bibr12-1971400920924799","doi-asserted-by":"publisher","DOI":"10.4103\/0971-3026.125626"},{"key":"bibr13-1971400920924799","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2016.08.014"},{"key":"bibr14-1971400920924799","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2257"},{"key":"bibr15-1971400920924799","doi-asserted-by":"publisher","DOI":"10.1177\/1971400919857556"},{"key":"bibr16-1971400920924799","doi-asserted-by":"publisher","DOI":"10.1177\/1971400919830173"}],"container-title":["The Neuroradiology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1971400920924799","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1971400920924799","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1971400920924799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:35:24Z","timestamp":1777588524000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1971400920924799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,13]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1177\/1971400920924799"],"URL":"https:\/\/doi.org\/10.1177\/1971400920924799","relation":{},"ISSN":["1971-4009","2385-1996"],"issn-type":[{"value":"1971-4009","type":"print"},{"value":"2385-1996","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,13]]}}}