{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:41:40Z","timestamp":1777876900528,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neuroradiol J"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>We present a case of a fatal cerebral haemorrhage in an 82-year-old male patient with coronavirus disease 2019 (COVID-19), who was taking prophylactic oral anticoagulation because of atrial fibrillation (rivaroxaban 20 mg q.d. for two years). On admission, the patient was deeply comatose, mechanically ventilated, with tachycardia up to 150 bpm, high blood pressure &gt;210\/120 mmHg and a body temperature &gt;39\u00b0C. A computed tomography scan of the head showed a large intracerebral haemorrhage located in the deep structures of the right hemisphere, with a mass effect and bleeding to the ventricles. Rivaroxaban was discontinued at admission. The patient tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but he did not have typical symptoms of pneumonia. In the following days, the patient\u2019s neurological condition did not improve, and a fever of up to 40\u00b0C and abnormal coagulation parameters remained resistant to pharmacotherapy. The patient developed multi-system organ failure and died on day 8. Here, we review the recent literature and discuss the possible association of SARS-CoV-2-mediated endothelial injury and cardiovascular disorders with cerebrovascular complications. We postulate that anti-inflammatory treatment in COVID-19 and the stabilisation of endothelium functions can be particularly important in patients with pre-existing cardiovascular conditions.<\/jats:p>","DOI":"10.1177\/1971400920978438","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T06:12:49Z","timestamp":1607926369000},"page":"147-150","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Fatal intracranial haemorrhage in a hypertensive patient with atrial fibrillation and coronavirus disease 2019"],"prefix":"10.1177","volume":"34","author":[{"given":"Ewa","family":"Krzystanek","sequence":"first","affiliation":[{"name":"Department of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justyna","family":"Gawryluk","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6090-6344","authenticated-orcid":false,"given":"Michal","family":"Arkuszewski","sequence":"additional","affiliation":[{"name":"Institute for Innovative Medicine, Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"key":"bibr1-1971400920978438","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.1127"},{"key":"bibr2-1971400920978438","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13266"},{"key":"bibr4-1971400920978438","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30937-5"},{"key":"bibr5-1971400920978438","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2020-000431"},{"key":"bibr6-1971400920978438","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2020.04.037"},{"key":"bibr7-1971400920978438","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00227"},{"key":"bibr8-1971400920978438","unstructured":"Global Health 5050. Sex, gender and Covid-19: 2020, https:\/\/globalhealth5050.org\/covid19\/ (accessed 5 July 2020)."},{"key":"bibr9-1971400920978438","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-020-00304-9"},{"key":"bibr10-1971400920978438","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa373"},{"key":"bibr11-1971400920978438","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14849"},{"key":"bibr12-1971400920978438","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2020.03.014"},{"key":"bibr13-1971400920978438","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"bibr14-1971400920978438","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.163"},{"key":"bibr15-1971400920978438","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-020-00818-9"},{"key":"bibr16-1971400920978438","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.0994"},{"key":"bibr17-1971400920978438","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb2507"},{"key":"bibr18-1971400920978438","doi-asserted-by":"crossref","unstructured":"Carroll E, Lewis A. Catastrophic intracranial hemorrhage in two critically ill patients with COVID-19.\n                      Neurocrit Care\n                      . Epub ahead of print 26 May 2020. DOI: 10.1007\/s12028-020-00993-5.","DOI":"10.1007\/s12028-020-00993-5"},{"key":"bibr19-1971400920978438","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30858-8"}],"container-title":["The Neuroradiology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1971400920978438","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1971400920978438","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1971400920978438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:35:48Z","timestamp":1777588548000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1971400920978438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,14]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1177\/1971400920978438"],"URL":"https:\/\/doi.org\/10.1177\/1971400920978438","relation":{},"ISSN":["1971-4009","2385-1996"],"issn-type":[{"value":"1971-4009","type":"print"},{"value":"2385-1996","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,14]]}}}