{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:42:05Z","timestamp":1777876925954,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Universidad Espiritu Santo - Ecuador","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neuroradiol J"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>Information on the association between anatomical variants of the Circle of Willis (CoW) and intracranial atherosclerotic disease (ICAD) is limited and results are controversial. In this population-based study, we aimed to assess whether an incomplete CoW is associated with high calcium content in carotid siphons (a reliable biomarker of ICAD) in community-dwelling older adults of Amerindian ancestry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Individuals aged \u226560 years enrolled in the Three Villages Study received a head computed tomography (CT) and magnetic resonance angiogram (MRA) of intracranial vessels. The CoW was classified in complete or incomplete according to the presence or absence of one A\n                      <jats:sub>1<\/jats:sub>\n                      segment of the anterior cerebral artery or one or both P\n                      <jats:sub>1<\/jats:sub>\n                      segments of posterior cerebral arteries. Calcium content in carotid siphons was rated as low or high. A multivariate logistic model was fitted to assess the independent association between incompleteness of the CoW and high calcium content in carotid siphons, after adjusting for demographics and cardiovascular risk factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 581 individuals were enrolled (mean age: 71\u2009\u00b1\u20098.4 years; 57% women). MRA revealed an incomplete CoW in 227 (39%) individuals, and high-resolution CT disclosed high calcium content in carotid siphons in 185 (32%). A risk factor logistic regression model showed no independent association between incompleteness of the CoW and high calcium content in carotid siphons (odds ratio: 0.91; 95% confidence interval: 0.62\u20131.34; p\u2009=\u20090.631).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Study results disclosed no association between anatomical variants of the CoW and the presence of high calcium content in carotid siphons.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19714009211042890","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T13:48:25Z","timestamp":1630417705000},"page":"300-305","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Variants of the Circle of Willis as seen on magnetic resonance angiography and carotid siphon calcifications in community-dwelling older adults"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1917-8805","authenticated-orcid":false,"given":"Oscar H","family":"Del Brutto","sequence":"first","affiliation":[{"name":"School of Medicine, Universidad Esp\u00edritu Santo \u2013 Ecuador, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettsy Y.","family":"Recalde","sequence":"additional","affiliation":[{"name":"Community Center, The Atahualpa Project, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robertino M","family":"Mera","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gilead Sciences, Inc., 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