{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:30:37Z","timestamp":1785364237753,"version":"3.55.0"},"reference-count":77,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000924","name":"MS Research Australia","doi-asserted-by":"crossref","award":["18-0533"],"award-info":[{"award-number":["18-0533"]}],"id":[{"id":"10.13039\/501100000924","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neuroradiol J"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Multiple sclerosis (MS) is a long-term autoimmune inflammatory disorder that affects the central nervous system leading to neurodegeneration, and can involve a variety of symptoms. These symptoms can include fatigue, anxiety, depression, and cognitive decline, which may be silent. The objective of this study was to explore changes in brain iron deposition in people with relapsing-remitting MS (pw-RRMS) compared to healthy controls (HCs), with a particular focus on regions of fear circuit. Additionally, the study aimed to evaluate relationship between iron deposition in these areas and clinical measurements.\n                    <jats:bold>Methods:<\/jats:bold>\n                    Pw-RRMS and HCs participants underwent brain MRI scans using quantitative susceptibility mapping (QSM) to assess iron deposition in the fear circuit between the two groups. The study analyzed correlations between brain susceptibility changes and clinical measurements.\n                    <jats:bold>Results:<\/jats:bold>\n                    We recruited 35 pw-RRMS (mean age = 46.7 \u00b1 11\u00a0years; median EDSS = 2.5) and 18 HCs (mean age = 40.6 \u00b1 17.8\u00a0years). Our research revealed significant increases in QSM signals relating to iron deposition in pw-RRMS compared to HCs, whole fear circuit (\u03b2 = 5.82,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001), caudate (\u03b2 = 21.48,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001), and putamen (\u03b2 = 17.53,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.03), showing the greatest difference. The whole fear circuit and particularly the caudate are strongly associated with fatigue in pw-RRMS. QSM values in the anterior cingulate cortex significantly differed between pw-RRMS with normal and abnormal depression scores (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.007).\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    These results strengthen the relationship between increased iron deposition in fear circuit regions and specific silent symptoms in pw-RRMS. However, further studies are required to confirm these findings and clarify the implications of iron accumulation in MS pathophysiology.\n                  <\/jats:p>","DOI":"10.1177\/19714009241303123","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T16:33:47Z","timestamp":1733330027000},"page":"464-474","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Quantitative susceptibility mapping of the fear circuit: Associations with silent symptoms in relapsing-remitting multiple sclerosis"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5002-2166","authenticated-orcid":false,"given":"Ibrahim","family":"Khormi","sequence":"first","affiliation":[{"name":"School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia"},{"name":"Hunter Medical Research Institute, New Lambton Heights, NSW, Australia"},{"name":"Department of Applied Radiologic Technology, College of Applied Medical Sciences, University of Jeddah, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Fazlollahi","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Melbourne, Melbourne, VIC, Australia"},{"name":"Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oun","family":"Al-iedani","sequence":"additional","affiliation":[{"name":"Hunter Medical Research Institute, New Lambton Heights, NSW, Australia"},{"name":"School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishma","family":"Vidyasagar","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Melbourne, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Ayton","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia"},{"name":"The Florey Department of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4893-223X","authenticated-orcid":false,"given":"Abdulaziz","family":"Alshehri","sequence":"additional","affiliation":[{"name":"School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia"},{"name":"Hunter Medical Research Institute, New Lambton Heights, NSW, Australia"},{"name":"Department of Radiology, King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Paton","sequence":"additional","affiliation":[{"name":"Hunter Medical Research Institute, New Lambton Heights, NSW, Australia"},{"name":"School of Psychological Sciences, College of Engineering, Science, and the Environment, University of Newcastle, Callaghan, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3874-7866","authenticated-orcid":false,"given":"Saadallah","family":"Ramadan","sequence":"additional","affiliation":[{"name":"School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia"},{"name":"Hunter Medical Research Institute, New Lambton Heights, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannette","family":"Lechner-Scott","sequence":"additional","affiliation":[{"name":"Hunter Medical Research Institute, New Lambton Heights, NSW, Australia"},{"name":"Department of Neurology, John Hunter Hospital, New Lambton Heights, Australia"},{"name":"School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2019.101453"},{"key":"e_1_3_6_3_2","volume-title":"Overview of fatigue and multiple sclerosis","author":"National Multiple Sclerosis Society","year":"2024","unstructured":"National Multiple Sclerosis Society. Overview of fatigue and multiple sclerosis. New York, NY: National Multiple Sclerosis Society, 2024. Accessed December 2, 2024. https:\/\/www.nationalmssociety.org\/Symptoms-Diagnosis\/MS-Symptoms\/Fatigue."},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2019.03.007"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-021-00239-2"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-13498-2_11"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458517711273"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.5119"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.181"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0210375"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02476-0"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.118"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23974"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2023.104934"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12987"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4726"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.2399"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2008.00296.x"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.248575"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3945"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13978"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3322"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1116516"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2020.09.020"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28404"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.20110272"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.05.036"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1176\/foc.9.3.foc311"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.121"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585231169466"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2022.05.009"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30470-2"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22366"},{"key":"e_1_3_6_34_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.11.1444"},{"key":"e_1_3_6_35_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520460115022"},{"key":"e_1_3_6_36_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.11.1956"},{"key":"e_1_3_6_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_3_6_38_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458509347150"},{"key":"e_1_3_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.05.008"},{"key":"e_1_3_6_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.23000"},{"key":"e_1_3_6_41_2","first-page":"3265","article-title":"STI Suite: a software package for quantitative susceptibility imaging","volume":"22","author":"Li W","year":"2014","unstructured":"Li W, Wu B, Liu C. STI Suite: a software package for quantitative susceptibility imaging. Proc Intl Soc Mg Reson Med. 2014; 22: 3265.","journal-title":"Proc Intl Soc Mg Reson Med"},{"key":"e_1_3_6_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa436"},{"key":"e_1_3_6_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1636-z"},{"key":"e_1_3_6_44_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10110968"},{"key":"e_1_3_6_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2022.102979"},{"key":"e_1_3_6_46_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17010100"},{"key":"e_1_3_6_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.11.010"},{"key":"e_1_3_6_48_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458519876032"},{"key":"e_1_3_6_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-51110-2"},{"key":"e_1_3_6_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-13498-2_3"},{"key":"e_1_3_6_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.04.008"},{"key":"e_1_3_6_52_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41747-022-00279-9"},{"key":"e_1_3_6_53_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0202918"},{"key":"e_1_3_6_54_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018180136"},{"key":"e_1_3_6_55_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00734"},{"key":"e_1_3_6_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6147-1"},{"key":"e_1_3_6_57_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5109"},{"key":"e_1_3_6_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25306"},{"key":"e_1_3_6_59_2","first-page":"6492786","article-title":"Deep gray matter iron content in neuromyelitis optica and multiple sclerosis","volume":"1","author":"Adam P","year":"2020","unstructured":"Adam P, et al. Deep gray matter iron content in neuromyelitis optica and multiple sclerosis. BioMed Res Int. 2020; 1: 6492786.","journal-title":"BioMed Res Int"},{"key":"e_1_3_6_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.10.063"},{"key":"e_1_3_6_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2019.05.028"},{"key":"e_1_3_6_62_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-307712"},{"key":"e_1_3_6_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-019-0371-x"},{"key":"e_1_3_6_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.11.017"},{"key":"e_1_3_6_65_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00194"},{"key":"e_1_3_6_66_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081093"},{"key":"e_1_3_6_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.30006"},{"key":"e_1_3_6_68_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3366"},{"key":"e_1_3_6_69_2","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12548"},{"key":"e_1_3_6_70_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514530022"},{"key":"e_1_3_6_71_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004150170184"},{"key":"e_1_3_6_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2023.105021"},{"key":"e_1_3_6_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2018.12.029"},{"key":"e_1_3_6_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2019.05.028"},{"key":"e_1_3_6_75_2","doi-asserted-by":"publisher","DOI":"10.21037\/qims-21-1137"},{"key":"e_1_3_6_76_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2017.00442"},{"key":"e_1_3_6_77_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514558474"},{"key":"e_1_3_6_78_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp095"}],"container-title":["The Neuroradiology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19714009241303123","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19714009241303123","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19714009241303123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:39:05Z","timestamp":1777588745000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19714009241303123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,4]]},"references-count":77,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1177\/19714009241303123"],"URL":"https:\/\/doi.org\/10.1177\/19714009241303123","relation":{},"ISSN":["1971-4009","2385-1996"],"issn-type":[{"value":"1971-4009","type":"print"},{"value":"2385-1996","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,4]]}}}