{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:44:00Z","timestamp":1777877040260,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neuroradiol J"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>\n                    <jats:bold>Purpose:<\/jats:bold>\n                    Non- traumatic subarachnoid hemorrhage (SAH) constitutes a life-threatening event, which is caused in 85% by ruptured aneurysms. Identifying those aneurysms as the bleeding cause is essential for further therapy. This study explores whether relatively hypodense sparing of aneurysms in the blood-filled subarachnoid space (filling defect sign = FD) on nonenhanced CT scans (NECT) can help estimate aneurysm location and size.\n                    <jats:bold>Methods:<\/jats:bold>\n                    NECT of fifty patients with aneurysmal SAH, who were also examined with a catheter angiography, were retrospectively analyzed by three neuroradiologically experienced radiologists. They rated the aneurysm location and size by applying the FD. Logistic regression analysis was performed to determine if a correlation between aneurysm location, aneurysm size, Fisher score and the detectability of a FD exists. For quantitative analysis the average densities of the aneurysm were compared to that of surrounding structures.\n                    <jats:bold>Results:<\/jats:bold>\n                    In 75% of the cases, the aneurysm was identified correctly by using the FD. The highest detection rate was given for MCA (90%) and BA aneurysms (90%). Aneurysm location (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = .019), size (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = .020), and the Fisher score (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = .008) significantly influenced aneurysm detection using the FD. The aneurysm size measured in correctly identified aneurysms correlated significantly with the sizes measured in the catheter angiography (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; .001). A cut-off point of 51 HU could be determined to distinguish aneurysm from surrounding SAH with a specificity of 92% and a sensitivity of 86%.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    In three-fourths aneurysm location and size can be determined on NECT using the FD. An additional quantitative analysis can support the diagnosis with a high specificity and sensitivity.\n                  <\/jats:p>","DOI":"10.1177\/19714009251348620","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T23:42:22Z","timestamp":1750203742000},"page":"197-203","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Detection of cerebral aneurysms in nonenhanced CT images of patients with subarachnoid hemorrhage using the filling defect sign"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4799-6808","authenticated-orcid":false,"given":"Tristan","family":"Klintz","sequence":"first","affiliation":[{"name":"University Hospital of Schleswig-Holstein"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justus","family":"Cordt","sequence":"additional","affiliation":[{"name":"University Hospital of Schleswig-Holstein"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Larsen","sequence":"additional","affiliation":[{"name":"University Hospital of Schleswig-Holstein"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Hensler","sequence":"additional","affiliation":[{"name":"University Hospital of Schleswig-Holstein"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fritz","family":"Wodarg","sequence":"additional","affiliation":[{"name":"University Hospital of Schleswig-Holstein"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olav","family":"Jansen","sequence":"additional","affiliation":[{"name":"University Hospital of Schleswig-Holstein"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f6nke","family":"Peters","sequence":"additional","affiliation":[{"name":"University Hospital of Schleswig-Holstein"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70025-0"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.2.249"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1968.28.1.0014"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e3182587839"},{"key":"e_1_3_5_6_2","unstructured":"Go AS Mozaffarian D Roger VL et al. 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