{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:44:00Z","timestamp":1777877040752,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T00:00:00Z","timestamp":1753574400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neuroradiol J"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Reduced Temporal Muscle Thickness (TMT) has been proposed as a marker of sarcopenia in Parkinson\u2019s Disease (PD) and Essential Tremor (ET). This study aimed to assess TMT measured on brain MRI in PD and ET patients undergoing unilateral Vim thalamotomy with MR-guided Focused Ultrasound (MRgFUS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective single-center study (2019\u20132023) included patients with tremor-dominant PD or ET refractory to medical therapy. Demographic data, disease duration, and tremor severity (Fahn-Tolosa-Marin scale) were collected. Brain MRI and clinical evaluations were performed at baseline and during follow-up (1\u00a0month, 6\u00a0months, 1\u00a0year, and 2\u00a0years). TMT was manually measured on axial T1-weighted MR images. Statistical analyses evaluated differences and correlations between TMT and clinical variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 165 patients (69 PD, 96 ET) were analyzed. Disease duration was longer in ET patients (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001), with no significant age difference. TMT did not differ significantly between PD and ET groups (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.08). In ET patients, TMT correlated nega-tively with age (r = \u22120.24,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.03), while no correlation was found in PD patients. At 2\u00a0year follow-up, TMT negatively correlated with tremor reduction in both PD (r = \u22120.42,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.03) and ET (r = \u22120.34,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.05) groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In our series, no significant differences emerged between ET and PD patients regarding TMT status as a surrogate marker of sarcopenia. Lower TMT may be associated with worse tremor outcomes after MRgFUS thalamotomy and could serve as a supportive imaging biomarker in patient assessment for tremor treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19714009251362817","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T02:41:59Z","timestamp":1753670519000},"page":"247-253","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Temporal muscle thickness on brain MRI as a surrogate marker of sarcopenia and treatment response in tremor patients undergoing MRgFUS thalamotomy"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1444-2585","authenticated-orcid":false,"given":"Federico","family":"Bruno","sequence":"first","affiliation":[{"name":"University of L\u2019Aquila"},{"name":"San Salvatore Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaspare","family":"Saltarelli","sequence":"additional","affiliation":[{"name":"University of L\u2019Aquila"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Di Cerbo","sequence":"additional","affiliation":[{"name":"University of L\u2019Aquila"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Innocenzi","sequence":"additional","affiliation":[{"name":"University of L\u2019Aquila"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro","family":"Di Terlizzi","sequence":"additional","affiliation":[{"name":"University of L\u2019Aquila"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Sucapane","sequence":"additional","affiliation":[{"name":"San Salvatore Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Cerone","sequence":"additional","affiliation":[{"name":"San Salvatore Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Catalucci","sequence":"additional","affiliation":[{"name":"San Salvatore Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierpaolo","family":"Palumbo","sequence":"additional","affiliation":[{"name":"University of L\u2019Aquila"},{"name":"San Salvatore Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Arrigoni","sequence":"additional","affiliation":[{"name":"University of L\u2019Aquila"},{"name":"San Salvatore Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Barile","sequence":"additional","affiliation":[{"name":"University of L\u2019Aquila"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Di Cesare","sequence":"additional","affiliation":[{"name":"University of L\u2019Aquila"},{"name":"San Salvatore Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Pistoia","sequence":"additional","affiliation":[{"name":"University of L\u2019Aquila"},{"name":"San Salvatore Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2188-3506","authenticated-orcid":false,"given":"Alessandra","family":"Splendiani","sequence":"additional","affiliation":[{"name":"University of L\u2019Aquila"},{"name":"San Salvatore Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,27]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001448"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2020.104089"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-023-01748-w"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq034"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2022.2096004"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2023.112077"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00053"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-012-0386-4"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-022-11268-8"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-023-07007-0"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0207849"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-023-01630-9"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-021-02086-0"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-020-06712-0"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.3171\/2017.11.FOCUS17614"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2021.1921572"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-020-01186-y"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11091183"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-022-04180-8"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-225108"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9051272"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afac135"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(22)00053-8"}],"container-title":["The Neuroradiology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19714009251362817","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19714009251362817","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19714009251362817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:39:38Z","timestamp":1777588778000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19714009251362817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,27]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1177\/19714009251362817"],"URL":"https:\/\/doi.org\/10.1177\/19714009251362817","relation":{},"ISSN":["1971-4009","2385-1996"],"issn-type":[{"value":"1971-4009","type":"print"},{"value":"2385-1996","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,27]]}}}