{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:18:32Z","timestamp":1788412712394,"version":"build-2803163510"},"reference-count":30,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neuroradiol J"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The patient-associated prevalence of Clopidogrel (CPG)\u2014and Aspirin (ASS)\u2014nonresponse is not well understood and varies depending on the patient population. The influence of responder status for platelet inhibition in patients eligible for carotid artery stenting (CAS) on post-interventional cerebral ischemia is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective, mono-center analysis of all patients with response-test undergoing elective CAS between 2010 and 2024 and available MRI before and after CAS. Study groups were formed according to ASS- and CPG-response. Cerebral ischemia patterns were compared between study groups in univariate analysis and patient-associated co-morbidities were tested for association with drug resistance or infarction frequency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 50\/68 (73.5%) of patients showed adequate response to ASS and CPG. Non-response to CPG was higher than to ASS (clopidogrel resistance rate: 14.8%, aspirin resistance rate: 9.2%). All patients with non-response were bridged with GP IIb\/IIIa antagonist tirofiban during CAS. Under these conditions, the responder status did not influence post-interventional cerebral infarction patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Antiplatelet non-response, especially for CPG, is very frequent in patients undergoing CAS. When bridging patients with tirofiban during intervention, responder status had no influence on post-interventional cerebral infarction patterns.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19714009251372360","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T23:45:03Z","timestamp":1756511103000},"page":"322-327","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Drug response testing for elective carotid artery stenting: Prevalence of non-response to aspirin and clopidogrel and influence on post-interventional occurrence of cerebral ischemia"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3705-7380","authenticated-orcid":false,"given":"Farzaneh","family":"Yousefi","sequence":"first","affiliation":[{"name":"University Hospital RWTH Aachen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimah","family":"Hasan","sequence":"additional","affiliation":[{"name":"University Hospital RWTH Aachen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6041-1632","authenticated-orcid":false,"given":"Frederic","family":"De Beukelaer","sequence":"additional","affiliation":[{"name":"University Hospital RWTH Aachen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani","family":"Ridwan","sequence":"additional","affiliation":[{"name":"University Hospital RWTH Aachen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omid","family":"Nikoubashman","sequence":"additional","affiliation":[{"name":"University Hospital RWTH Aachen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Wiesmann","sequence":"additional","affiliation":[{"name":"University Hospital RWTH Aachen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1374-7854","authenticated-orcid":false,"given":"Charlotte S","family":"Weyland","sequence":"additional","affiliation":[{"name":"University Hospital RWTH Aachen"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"e_1_3_7_2_2","first-page":"17S","article-title":"Embolic protection devices for carotid artery stenting: a network meta-analysis","volume":"77","author":"Giannopoulos S","year":"2022","unstructured":"Giannopoulos S, Sagris M, Giannopoulos S, et al. Embolic protection devices for carotid artery stenting: a network meta-analysis. Vascular 2022; 77: 17S\u201318S.","journal-title":"Vascular"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2005.01.012"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000221298.43117.be"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.3171\/2017.5.JNS162307"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S44469"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3405"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/1591019918808777"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2012.05.107"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.11.038"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2013.02.019"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000332614"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-14-84"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70236-4"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.5644\/ama2006-124.367"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.5797\/jnet.oa.2020-0170"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2013.54.2.288"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep25478"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1703"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.92.15_supplement.P1.3-007"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.53.2918"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2021.05.031"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2015.08.013"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.09.010"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.12.044"},{"key":"e_1_3_7_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21359"},{"key":"e_1_3_7_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.514356"},{"issue":"1","key":"e_1_3_7_28_2","first-page":"11","article-title":"Factors associated with increased rates of post-procedural stroke or death following carotid artery stent placement: a systematic review","volume":"7","author":"Khan M","year":"2014","unstructured":"Khan M, Qureshi AI. Factors associated with increased rates of post-procedural stroke or death following carotid artery stent placement: a systematic review. J Vasc Interv Neurol 2014; 7(1): 11\u201320.","journal-title":"J Vasc Interv Neurol"},{"key":"e_1_3_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2019.09.024"},{"key":"e_1_3_7_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2013-010873"},{"key":"e_1_3_7_31_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0543"}],"container-title":["The Neuroradiology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19714009251372360","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19714009251372360","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19714009251372360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:03:07Z","timestamp":1788411787000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19714009251372360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,29]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1177\/19714009251372360"],"URL":"https:\/\/doi.org\/10.1177\/19714009251372360","relation":{},"ISSN":["1971-4009","2385-1996"],"issn-type":[{"value":"1971-4009","type":"print"},{"value":"2385-1996","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,29]]}}}