{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:18:32Z","timestamp":1788412712278,"version":"build-2803163510"},"reference-count":28,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neuroradiol J"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The acute management of ruptured intracranial aneurysms sometimes requires stent placement, which necessitates the prompt initiation of an antiplatelet (APT) regimen, including Ticagrelor at our center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to assess patients with ruptured intracranial aneurysms who received Ticagrelor prior to or during aneurysm embolization. We evaluated procedural safety and clinical and imaging outcomes at 6 months follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We analyzed patients with aneurysmal subarachnoid hemorrhage treated with endovascular therapy (EVT) under a dual antiplatelet therapy (DAPT) regimen between January 2015 and January 2023, excluding those managed with surgical clipping. Safety profiles and clinical outcomes were systematically assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 23 patients (69.6% female, mean age 58.6 \u00b1 12.2\u00a0years) with ruptured aneurysms and subarachnoid hemorrhage underwent EVT with DAPT (Ticagrelor + Aspirin). Aneurysms were primarily located on the carotid (39.1%) and anterior communicating arteries (30.4%), with a median size of 5\u00a0mm. The median time from rupture to treatment was 1.5\u00a0days. Ischemic complications occurred in 30.4%, including procedure-related ischemia (21.7%) and post-procedure vasospasm (8.7%). Hemorrhagic complications were observed in 8.7%, with two patients experiencing asymptomatic post-procedure hemorrhage. Functional outcomes at 6 months showed 56.5% of patients with excellent recovery (mRS &lt;2), while 17.4% died (mRS = 6), resulting in a 17.4% mortality rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ticagrelor appears feasible and generally safe for acute-phase management of aneurysmal subarachnoid hemorrhage, though complications and mortality highlight the need for cautious patient selection and further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19714009251389566","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T20:39:14Z","timestamp":1761251954000},"page":"360-366","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ticagrelor use in ruptured aneurysms: A retrospective cohort study"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4277-9767","authenticated-orcid":false,"given":"Nourou Dine Adeniran","family":"Bankole","sequence":"first","affiliation":[{"name":"Clinical investigation center (CIC) INSERM 1415, CHRU de Tours"},{"name":"Tours University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baptiste","family":"Donnard","sequence":"additional","affiliation":[{"name":"Tours University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregoire","family":"Boulouis","sequence":"additional","affiliation":[{"name":"Clinical investigation center (CIC) INSERM 1415, CHRU de Tours"},{"name":"Tours University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohann","family":"Nalbach","sequence":"additional","affiliation":[{"name":"Tours University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Masson","sequence":"additional","affiliation":[{"name":"Tours University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Janot","sequence":"additional","affiliation":[{"name":"Tours University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heloise","family":"Ifergan","sequence":"additional","affiliation":[{"name":"Tours University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6748-2081","authenticated-orcid":false,"given":"Fouzi","family":"Bala","sequence":"additional","affiliation":[{"name":"Tours University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Bibi","sequence":"additional","affiliation":[{"name":"Tours University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2023-020181"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010618"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2228"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3171\/2017.5.JNS162307"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyy002"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/19714009231224408"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1227\/neu.0000000000003507"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2014-011258"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/159101991001600204"},{"issue":"3","key":"e_1_3_4_11_2","first-page":"159101992211179","article-title":"Treatment of ruptured intracranial aneurysms using the novel generation of flow-diverters with surface modification: a systematic review and meta-analysis","volume":"30","author":"Monteiro A","year":"2022","unstructured":"Monteiro A, Khan A, Donnelly BM, et al. 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