{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:58:33Z","timestamp":1792166313051,"version":"4.4.0"},"reference-count":58,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neuroradiol J"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This meta-analysis aimed to evaluate the pooled prevalence of key cranial magnetic resonance imaging (MRI) findings in methanol poisoning, including putaminal necrosis, optic nerve injury, and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Methanol intoxication is a potentially fatal condition causing severe neurological deficits, yet the prevalence of MRI-detected brain lesions remains incompletely characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A systematic review and meta-analysis were conducted following PRISMA 2020 and Cochrane Handbook guidelines. Studies reporting MRI findings in patients with confirmed methanol poisoning were retrieved from Medline, Scopus, and Web of Science. A random-effects model was used to pool proportions, and heterogeneity was assessed using the I\n                      <jats:sup>2<\/jats:sup>\n                      statistic.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirteen studies were included in the systematic review. Of these, eight studies contributed data on putaminal necrosis (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 163), four on optic nerve injury (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 108), and seven on in-hospital mortality (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 154). Patients were predominantly male, aged 17\u201377 years, with oral ingestion as the main exposure route. Mortality showed a pooled prevalence of 7.8% (95% CI 2.2\u201324.1; I\n                      <jats:sup>2<\/jats:sup>\n                      = 53.9%). Optic nerve injury had a pooled prevalence of 36.1% (95% CI 9.2\u201375.8; I\n                      <jats:sup>2<\/jats:sup>\n                      = 84.0%). Putaminal necrosis was the most frequent MRI finding, with a pooled prevalence of 47.6% (95% CI 30.3\u201365.6; I\n                      <jats:sup>2<\/jats:sup>\n                      = 75.0%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MRI abnormalities are highly prevalent in methanol poisoning. Putaminal necrosis is the hallmark radiologic feature, while optic nerve injury affects approximately one-third of cases. These findings support MRI as a key tool for assessing methanol-induced neurotoxicity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19714009261423701","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T13:33:09Z","timestamp":1771507989000},"page":"599-610","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Cranial magnetic resonance imaging findings in methanol poisoning: Systematic review and meta-analysis of radiological prevalence"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5439-3928","authenticated-orcid":false,"given":"Rebeca Oliveira","family":"da Silva","sequence":"first","affiliation":[{"name":"Federal University of Para\u00edba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8742-1818","authenticated-orcid":false,"given":"Victor Arthur","family":"Ohannesian","sequence":"additional","affiliation":[{"name":"Albert Einstein Israeli Faculty of Health Sciences (FICSAE)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Nobre","family":"Aguirre","sequence":"additional","affiliation":[{"name":"Einstein Hospital Israelita"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Gon\u00e7alves da Silva Miroski","family":"Gerente","sequence":"additional","affiliation":[{"name":"University of South Santa Catarina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Othon Trevisan","family":"Meira","sequence":"additional","affiliation":[{"name":"Institute of Neurology of Curitiba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4476-2357","authenticated-orcid":false,"given":"Cid","family":"Soares","sequence":"additional","affiliation":[{"name":"UniAtenas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vit\u00f3ria","family":"Palazoni","sequence":"additional","affiliation":[{"name":"University of Miami"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6561-5087","authenticated-orcid":false,"given":"Pedro L\u00edvio Gomes","family":"Moura","sequence":"additional","affiliation":[{"name":"Santa Maria University Center (UNIFSM)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Araujo","family":"Gouhie","sequence":"additional","affiliation":[{"name":"Federal University of Uberl\u00e2ndia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo Haddad","family":"Santos","sequence":"additional","affiliation":[{"name":"Federal of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"e_1_3_4_2_2","volume-title":"The basic chemical and energy feedstock of the future","author":"Bertau M","year":"2014","unstructured":"Bertau M, Offermanns H, Plass L, et al. 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