{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:07:47Z","timestamp":1790856467345,"version":"4.1.0"},"reference-count":46,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neuroradiol J"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Basilar artery occlusion accounts for a small fraction of ischemic strokes but carries a disproportionally poor natural history, with high rates of death and disability under best medical therapy (BMT). Endovascular treatment is used to treat these patients, though evidence of its safety and efficacy in different time windows compared to BMT remains conflicted. To address this, this Bayesian meta-analysis evaluates the outcomes of endovascular treatment for basilar artery occlusion performed in early (0\u20136\u00a0h) and late (&gt;6\u00a0h) windows versus BMT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Following PRISMA guidelines, databases were searched through for studies comparing endovascular versus BMT in patients with basilar artery occlusion. Randomized controlled trials, prospective, and retrospective studies reporting at least one clinical outcome were included. A Bayesian random-effects network meta-analysis was performed to compare endovascular treatment within 0\u20136\u00a0h and beyond 6\u00a0h with BMT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seven studies comprising 4,125 patients were included. EVT demonstrated superior functional outcomes compared to BMT across both time windows, with the late (&gt;6\u00a0h) window showing a higher probability of achieving favorable modified Rankin Scale (mRS) scores (0\u20132). Mortality reduction was not consistent, and both early and late EVT were associated with higher risks of hemorrhagic and overall complications. Despite these safety concerns, the overall benefit-to-risk balance favored EVT as the preferred therapy for BAO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings underscore the importance of imaging-based selection and individualized decision-making, suggesting that EVT beyond traditional time windows remains effective when guided by appropriate clinical and radiological criteria.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19714009261429231","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T22:26:29Z","timestamp":1772490389000},"page":"620-635","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Endovascular treatment for basilar artery occlusion: A Bayesian network meta-analysis comparing time-to-treatment windows and medical management"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1942-2363","authenticated-orcid":false,"given":"Lucca Tamara Alves","family":"Carretta","sequence":"first","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia de Vit\u00f3ria (EMESCAM)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ocilio Ribeiro","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Medicine, Federal University of Piaui"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4521-9041","authenticated-orcid":false,"given":"Luciano","family":"Falc\u00e3o","sequence":"additional","affiliation":[{"name":"Bahiana School of Medicine and Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Let\u00edcia","family":"de Bastos Maximiano","sequence":"additional","affiliation":[{"name":"Department of Medicine, Federal Fluminense University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Pari","family":"Mitre","sequence":"additional","affiliation":[{"name":"Santa Casa de S\u00e3o Paulo School of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolfh Batista","family":"Arend","sequence":"additional","affiliation":[{"name":"Department of Medicine, Federal University of Fronteira Sul - UFFS, Campus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Vitor Andrade","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Federal University of Para\u00edba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Rodrigues","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia de Vit\u00f3ria (EMESCAM)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Di Cosmo","sequence":"additional","affiliation":[{"name":"Humanitas University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tassiane Cristina","family":"Morais","sequence":"additional","affiliation":[{"name":"Escola Superior de Ci\u00eancias da Santa Casa de Miseric\u00f3rdia de Vit\u00f3ria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro de Assis","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Hospital Estadual Central"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6236-5633","authenticated-orcid":false,"given":"Ahmet","family":"G\u00fcnkan","sequence":"additional","affiliation":[{"name":"University of Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.0156"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/23969873241257223"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2030297"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30395-3"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206317"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2207576"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.031371"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.023361"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.7461\/jcen.2013.15.3.137"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.056554"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00923"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.696042"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-024-12375-4"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70229-0"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-201004"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13142425"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2022.02936"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/17474930211052262"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.629920"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.661955"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-015-1577-6"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010962"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-022-01301-z"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-020-00879-w"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706442"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713973"},{"issue":"1","key":"e_1_3_5_31_2","first-page":"20","article-title":"DAWN and DEFUSE-3 trials: is time still important?","volume":"58","author":"Ragoschke-Schumm A","year":"2018","unstructured":"Ragoschke-Schumm A, Walter S. DAWN and DEFUSE-3 trials: is time still important? Die DAWN- und DEFUSE-3-Studie: ist Zeit immer noch wichtig? Der Radiologe 2018; 58(Suppl 1): 20\u201323. https:\/\/doi.org\/10.1007\/s00117-018-0406-4","journal-title":"Die DAWN- und DEFUSE-3-Studie: ist Zeit immer noch wichtig? Der Radiologe"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.728012"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.1408"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2018-014576"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25669"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.035948"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2022-018769"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1177\/15910199221106049"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2024-022053"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1385\/NCC:1:3:319"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2023-020517"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2022.03755"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1177\/23969873241290442"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.040807"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1185304"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1177\/23969873231209616"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13144153"}],"container-title":["The Neuroradiology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19714009261429231","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19714009261429231","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19714009261429231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:37:46Z","timestamp":1790854666000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19714009261429231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,2]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1177\/19714009261429231"],"URL":"https:\/\/doi.org\/10.1177\/19714009261429231","relation":{},"ISSN":["1971-4009","2385-1996"],"issn-type":[{"value":"1971-4009","type":"print"},{"value":"2385-1996","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,2]]}}}