{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:57:00Z","timestamp":1792666620737,"version":"4.5.0"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rare Tumors"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Soft tissue leiomyosarcomas are rare, accounting for almost 5%\u201310% of all soft tissue sarcomas; they account for almost 1% of all sarcomas. They are aggressive tumors where location, size, and management require a multidisciplinary approach. Since there are few series published, we here analyze epidemiological pattern, clinical and pathologic features of soft tissue leiomyosarcomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a retrospective study of 29 consecutive cases of histologically proven soft tissue leiomyosarcoma extracted from the database of the Cancer Registry of the Center of Tunisia and the Department of Pathology of Farhat Hached University Hospital of Sousse of Tunisia, during a 10-year period (from January 1996 to December 2005). Epidemiologic details, clinico-pathological features, and treatment modalities were assessed with focus on patients\u2019 5-year overall survival, tumor relapse, and metastases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Soft tissue leiomyosarcoma accounted for 17.5% of all soft tissue sarcomas diagnosed at our pathology department. Most of patients were of advanced age (median: 52\u2009years), with extremes ranging from 12 and 87\u2009years. There was a slight male predominance (sex-ratio\u2009=\u20091.07). Tumors were located mostly in the lower limbs (45%). Deep sites as retroperitoneum was found only in two cases. Tumor size was more than 5\u2009cm in 83% of cases (average size\u2009=\u20099.4\u2009cm). Five cases had metastasis on initial staging. For 24 patients, the disease was locally limited at the moment of diagnosis. Palliative chemotherapy was indicated for four patients and surgery was performed for 20 patients. Local recurrence occurred in 11 patients (55% of operated patients) and metastasis in 6 patients. Overall, 5-year survival was about 24%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our study results highlight the scarcity of soft tissue leiomyosarcoma. Unfortunately, unusual tumor sites, disease\u2019s advanced stages, and intralesional resection made the prognosis poorer than in other series. Clinical course of soft tissue leiomyosarcoma was highly marked by local recurrence and metastasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2036361318820171","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T02:06:00Z","timestamp":1548122760000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Soft tissue leiomyosarcoma\u2014diagnostics, management, and prognosis: Data of the registry cancer of the center of Tunisia"],"prefix":"10.1177","volume":"11","author":[{"given":"Sarra","family":"Mestiri","sequence":"first","affiliation":[{"name":"Department of Pathology, Farhat Hached University Hospital, Sousse, Tunisia"},{"name":"Cancer Registry of the Center of Tunisia, Sousse, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Amine","family":"Elghali","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Farhat Hached University Hospital, Sousse, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rym","family":"Bourigua","sequence":"additional","affiliation":[{"name":"Department of Oncology, Farhat Hached University Hospital, Sousse, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihed","family":"Abdessayed","sequence":"additional","affiliation":[{"name":"Department of Pathology, Farhat Hached University Hospital, Sousse, Tunisia"},{"name":"Department of Oncology, Farhat Hached University Hospital, Sousse, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salsabil","family":"Nasri","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Farhat Hached University Hospital, Sousse, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben Abdallah","family":"Amine","sequence":"additional","affiliation":[{"name":"Department of Pathology, Farhat Hached University Hospital, Sousse, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabiha","family":"Missaoui","sequence":"additional","affiliation":[{"name":"Department of Pathology, Farhat Hached University Hospital, Sousse, Tunisia"},{"name":"Cancer Registry of the Center of Tunisia, Sousse, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Ben Maitig","sequence":"additional","affiliation":[{"name":"Department of Orthopedy, Hospital Sahloul, Sousse, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihem","family":"Hmissa","sequence":"additional","affiliation":[{"name":"Department of Pathology, Farhat Hached University Hospital, Sousse, Tunisia"},{"name":"Cancer Registry of the Center of Tunisia, Sousse, Tunisia"},{"name":"Research Unit UR14ES17, Cancer Epidemiology and Cytopathology in Tunisian Center, Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Badreddine","family":"Sriha","sequence":"additional","affiliation":[{"name":"Department of Pathology, Farhat Hached University Hospital, Sousse, Tunisia"},{"name":"Cancer Registry of the Center of Tunisia, Sousse, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moncef","family":"Mokni","sequence":"additional","affiliation":[{"name":"Department of Pathology, Farhat Hached University Hospital, Sousse, Tunisia"},{"name":"Cancer Registry of the Center of Tunisia, Sousse, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,1,21]]},"reference":[{"key":"bibr1-2036361318820171","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010515)91:10<1914::AID-CNCR1214>3.0.CO;2-3"},{"key":"bibr2-2036361318820171","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1990.394"},{"key":"bibr3-2036361318820171","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200201000-00002"},{"key":"bibr4-2036361318820171","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2011.147"},{"key":"bibr5-2036361318820171","volume-title":"Enzinger and Weiss\u2019s soft tissue tumors","author":"Goldblum 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