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The optimal treatment of these patients is surgical resection if possible; however, the role of chemotherapy has not been well defined. The patient described herein had a central tumor in the chest wall. Since many of these patients have borderline resectable tumors, the use of neoadjuvant chemotherapy may be helpful to downstage the tumors for possible surgical resection. In this case, doxorubicin plus ifosfamide chemotherapy was employed with a favorable therapeutic effect prior to being resected. To our knowledge this is the first report of greater than 90% necrosis in a patient with radiation-associated undifferentiated\/unclassified soft-tissue sarcoma treated with chemotherapy for a borderline resectable mass.<\/jats:p>","DOI":"10.1177\/2036361318821763","type":"journal-article","created":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T00:39:43Z","timestamp":1546821583000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Neoadjuvant chemotherapy for radiation-associated soft-tissue sarcoma: A case report"],"prefix":"10.1177","volume":"11","author":[{"given":"Ronak","family":"Patel","sequence":"first","affiliation":[{"name":"Internal Medicine, LAC + USC Medical Center, Glendale, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Hu","sequence":"additional","affiliation":[{"name":"Medical Oncology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shefali","family":"Chopra","sequence":"additional","affiliation":[{"name":"Pathology, Keck Medical Center, University of Southern California, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Lee","sequence":"additional","affiliation":[{"name":"Diagnostic Radiology, Keck Medical Center, University of Southern California, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,1,6]]},"reference":[{"key":"bibr1-2036361318821763","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1992.01420120013002"},{"key":"bibr2-2036361318821763","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v5.i5.973"},{"key":"bibr3-2036361318821763","doi-asserted-by":"publisher","DOI":"10.1080\/02841860802047387"},{"key":"bibr4-2036361318821763","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.559"},{"key":"bibr5-2036361318821763","doi-asserted-by":"publisher","DOI":"10.1186\/2045-3329-2-18"},{"key":"bibr6-2036361318821763","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980101)82:1<8::AID-CNCR3>3.0.CO;2-W"},{"issue":"2","key":"bibr7-2036361318821763","first-page":"1262","volume":"125","author":"Wong F","year":"1998","journal-title":"Am J Ophthalmol"},{"key":"bibr8-2036361318821763","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-000-0037-6"},{"key":"bibr9-2036361318821763","unstructured":"Rawat S. Radiation induced sarcomas in head and neck, https:\/\/www.slideshare.net\/shehrawat\/radiation-induced-sarcomas-in-head-and-neck (accessed 17 September 2011)."},{"key":"bibr10-2036361318821763","doi-asserted-by":"publisher","DOI":"10.3816\/CBC.2003.n.037"},{"key":"bibr11-2036361318821763","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133569"},{"key":"bibr12-2036361318821763","unstructured":"Borges N, Kapadia SR. Radiation-induced CAD: incidence, diagnosis, and management outcomes, https:\/\/www.acc.org\/latest-in-cardiology\/articles\/2018\/05\/24\/01\/44\/radiation-induced-cad (accessed 21 September 2018)."},{"key":"bibr13-2036361318821763","unstructured":"Lucasa DR, Kshirsagara MP, Biermannb JS, et al. Histologic alterations from neoadjuvant chemotherapy in high-grade extremity soft tissue sarcoma: clinicopathological correlation, http:\/\/theoncologist.alphamedpress.org\/content\/13\/4\/451.full.html (accessed 1 April 2008)."},{"issue":"23","key":"bibr14-2036361318821763","first-page":"6393","volume":"51","author":"Brachman DG","year":"1991","journal-title":"J Cancer Res"},{"key":"bibr15-2036361318821763","doi-asserted-by":"publisher","DOI":"10.2174\/138920212802510420"},{"key":"bibr16-2036361318821763","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4453-z"},{"key":"bibr17-2036361318821763","unstructured":"National Comprehensive Cancer Network. 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