{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:01:16Z","timestamp":1777878076688,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008958","name":"SANAD Children\u2019s Cancer Support Association","doi-asserted-by":"crossref","award":["Grant number: RGP-2017-12"],"award-info":[{"award-number":["Grant number: RGP-2017-12"]}],"id":[{"id":"10.13039\/501100008958","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rare Tumors"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Rare pediatric tumors are heterogeneous group containing a variety of histopathological diseases, they represent approximately 10% of all childhood cancers. These rare tumors had a diversity of histology and clinical behaviors that pose different challenges to the investigators. Exploring different pediatric rare tumors. The data were reviewed, retrospectively, through the medical records of seven rare pediatric diseases between 2012 and 2019. Giant cell fibroblastoma (GCF) presented as painless swelling in the trunk, positive for CD34 with PTEN gene mutation. Neuroglial heterotopic tissue presented in 7\u2009days old girl with facial asymmetry and bulging in the oral cavity, maximal de-bulking was done, histopathology was positive for GFAP and S100p. Left side neck mass, surgically excised revealed non-metastatic salivary grand mucoepidermoid carcinoma. Follow up without any chemotherapy or radiotherapy for 5\u2009years with complete remission. Mesenchymal chondrosarcoma (MCS) presented in maxillofacial bones by persistent nasal bleeding, HEY1-NCOA2 fusion gene confirmed the diagnosis. Extra-osseous Ewing sarcoma (EES) presented as rubbery painless swelling in the scalp with fusion transcript involving EWSR1-FL11. Juvenile xanthogranuloma (JXG) presented by butter fly like skin patch in the face with foamy histiocytes in upper dermis with few Touton giant cells, extensive systemic involvement of lung and bone marrow. Metastatic ovarian choriocarcinoma with choriocarcinoma syndrome received induction two different lines of chemotherapy and consolidated with autologous stem cell transplant. Seven pediatric rare tumors, with different aspects of challenges in diagnosis and management, despite the absence of formal protocols and rarity of other center experiences.<\/jats:p>","DOI":"10.1177\/2036361321997331","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T06:57:38Z","timestamp":1614149858000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Rare tumors in pediatric age group: Single center experience from Saudi Arabia"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5528-0025","authenticated-orcid":false,"given":"Yasser","family":"Elborai","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology, Pediatric Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia"},{"name":"Department of Pediatric Oncology, National Cancer Institute, Cairo University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nawaf","family":"Alkhayat","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology, Pediatric Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghaleb","family":"Elyamany","sequence":"additional","affiliation":[{"name":"Department of Central Military Laboratory and Blood Bank, Prince Sultan Military Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Alshahrani","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology, Pediatric Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walid","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology, Pediatric Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Othman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology, Pediatric Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasna","family":"Hamzi","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology, Pediatric Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal","family":"Binhassan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology, Pediatric Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansour S","family":"Aljabry","sequence":"additional","affiliation":[{"name":"Pathology department, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raniah","family":"Alqawahmed","sequence":"additional","affiliation":[{"name":"Department of Central Military Laboratory and Blood Bank, Prince Sultan Military Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasir","family":"alrusayni","sequence":"additional","affiliation":[{"name":"Department of Central Military Laboratory and Blood Bank, Prince Sultan Military Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khadijah","family":"Abdulhaleem","sequence":"additional","affiliation":[{"name":"Department of Central Military Laboratory and Blood Bank, Prince Sultan Military Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Alsuhaibani","sequence":"additional","affiliation":[{"name":"Department of Central Military Laboratory and Blood Bank, Prince Sultan Military Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Alsharif","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology, Pediatric Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,2,24]]},"reference":[{"key":"bibr1-2036361321997331","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21208"},{"key":"bibr2-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1327608"},{"key":"bibr3-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.2603"},{"key":"bibr4-2036361321997331","volume-title":"Cancer incidence and survival among children and adolescents: United States SEER Program 1975\u20131995","author":"Ries LAG","year":"1999"},{"key":"bibr5-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.3632"},{"key":"bibr6-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2006.12.010"},{"key":"bibr7-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3037"},{"key":"bibr8-2036361321997331","first-page":"339","volume":"20","author":"Harvell JD","year":"1998","journal-title":"Am J Surg Pathol"},{"key":"bibr9-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204426"},{"key":"bibr10-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01459.x"},{"key":"bibr11-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.01.027"},{"key":"bibr12-2036361321997331","doi-asserted-by":"publisher","DOI":"10.18203\/2320-6012.ijrms20161994"},{"issue":"1","key":"bibr13-2036361321997331","first-page":"96","volume":"26","author":"Chen CY","year":"2005","journal-title":"Am J Neuroradiol"},{"key":"bibr14-2036361321997331","unstructured":"Ribeiro RT, Barsottini OGP. Neurological diseases with pharyngeal dysfunction. Handbook of pharyngeal diseases: etiology, diagnosis and treatment."},{"key":"bibr15-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2009.05.014"},{"key":"bibr16-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2013.11.002"},{"key":"bibr17-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1985.00800070074011"},{"key":"bibr18-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2012.12.012"},{"key":"bibr19-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001303"},{"key":"bibr20-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.12.016"},{"issue":"2","key":"bibr21-2036361321997331","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4103\/0972-124X.170828","volume":"20","author":"Jarde SJ","year":"2016","journal-title":"J Indian Soc Periodontol"},{"key":"bibr22-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1054\/ijom.2001.0221"},{"key":"bibr23-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-014-0461-6"},{"key":"bibr24-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23457"},{"key":"bibr25-2036361321997331","volume":"4","author":"Fletcher CD","year":"2002","journal-title":"Pathology and genetics of tumours of soft tissue and bone"},{"key":"bibr26-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.03.012"},{"key":"bibr27-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-019-2799-2"},{"key":"bibr28-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.11.007"},{"key":"bibr29-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25840"},{"key":"bibr30-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-013-3409-2"},{"key":"bibr31-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-009-0828-5"},{"key":"bibr32-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2458-4"},{"key":"bibr33-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyq080"},{"key":"bibr34-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22756"},{"key":"bibr35-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2015.1.571"},{"key":"bibr36-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1590\/1984-0462\/;2019;37;2;00013"},{"key":"bibr37-2036361321997331","first-page":"77","volume":"17","author":"Zelger B","year":"2001","journal-title":"Adv Dermatol"},{"key":"bibr38-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1177\/1093526617721775"},{"key":"bibr39-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-004-1012-1"},{"key":"bibr40-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800310"},{"key":"bibr41-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-200x.2000.01236.x"},{"issue":"8","key":"bibr42-2036361321997331","first-page":"711","volume":"67","author":"Medina A","year":"2014","journal-title":"Arch Esp Urol"},{"key":"bibr43-2036361321997331","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12030611"},{"key":"bibr44-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1016\/j.currproblcancer.2020.100539"},{"key":"bibr45-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq021"},{"key":"bibr46-2036361321997331","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.6043"}],"container-title":["Rare Tumors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2036361321997331","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2036361321997331","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2036361321997331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:11:01Z","timestamp":1777590661000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2036361321997331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":46,"alternative-id":["10.1177\/2036361321997331"],"URL":"https:\/\/doi.org\/10.1177\/2036361321997331","relation":{},"ISSN":["2036-3613","2036-3613"],"issn-type":[{"value":"2036-3613","type":"print"},{"value":"2036-3613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"article-number":"2036361321997331"}}