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We present a rare case of MPE, recurrent in the pelvic soft tissue with eventual pleural and intra-pulmonary metastasis. Refractory to repeated gross resection, adjuvant radiotherapy, platinum-based chemotherapy and temozolomide exploitation of mutant somatic BRCA1 status with the addition of a poly (ADP-ribose); polymerase inhibitor (PARPi) in a novel combination regimen with olaparib-temozolomide (OT) has achieved stable radiological disease after 10 cycles.<\/jats:p>","DOI":"10.1177\/20363613231152333","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T06:15:34Z","timestamp":1674108934000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["PARP inhibition utilized in combination therapy with Olaparib\u2010Temozolomide to achieve disease stabilization in a rare case of BRCA1\u2010mutant, metastatic myxopapillary ependymoma"],"prefix":"10.1177","volume":"15","author":[{"given":"Preethika","family":"Mahalingam","sequence":"first","affiliation":[{"name":"The Royal Marsden Hospital NHS 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