{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:11:04Z","timestamp":1791231064874,"version":"4.1.0"},"reference-count":21,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rare Tumors"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>Signet-ring cell carcinomas are an aggressive, poorly differentiated, and highly invasive adenocarcinoma carrying a poor prognosis. Most of these tumors originate in gastrointestinal organs; however, primary lung signet-ring cell adenocarcinomas can rarely occur. Tumoral lymphatic infiltration is a complication of these tumors and can cause phenomena such as lymphangitic carcinomatosis, characterized by a nodular thickening of the pleura, pleural effusions, and mediastinal lymphadenopathies. We report a case of a 63-year-old ex-smoker with a 2-week clinical course of dyspnea and pleuritic chest pain in which a nodular thickening of the pleura and pleural effusion were documented and led to the diagnosis of a primary signet-ring cell adenocarcinoma of the lung with lymphangitic carcinomatosis. This complication has never been described in the context of a primary lung tumor of this subtype. Both entities carry a high mortality and have no therapeutical options. This report adds to the information available about them.<\/jats:p>","DOI":"10.1177\/20363613231164017","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:22:00Z","timestamp":1678753320000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Lymphangitic carcinomatosis as the initial manifestation of primary signet-ring cell adenocarcinoma of the lung: A case report"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0676-1770","authenticated-orcid":false,"given":"David","family":"Corredor-Orlandelli","sequence":"first","affiliation":[{"name":"School of Medicine and Health Sciences, Universidad del Rosario, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Vargas","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Fundaci\u00f3n Cardioinfantil - LaCardio, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"key":"bibr1-20363613231164017","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(89)90229-3"},{"key":"bibr2-20363613231164017","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2018.1416291"},{"key":"bibr3-20363613231164017","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181ce3b93"},{"key":"bibr4-20363613231164017","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90111-9"},{"key":"bibr5-20363613231164017","doi-asserted-by":"publisher","DOI":"10.21037\/tcr.2019.11.54"},{"key":"bibr6-20363613231164017","first-page":"752","volume":"21","author":"Cai Y","year":"2021","journal-title":"Bosn J Basic Med Sci"},{"key":"bibr7-20363613231164017","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.4785.639"},{"key":"bibr8-20363613231164017","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.080142"},{"key":"bibr9-20363613231164017","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-5-638"},{"key":"bibr10-20363613231164017","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198609000-00037"},{"key":"bibr11-20363613231164017","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.919412"},{"issue":"5","key":"bibr12-20363613231164017","first-page":"332","volume":"115","author":"Khachekian A","year":"2015","journal-title":"J Am Osteopath Assoc"},{"key":"bibr13-20363613231164017","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr-21-654"},{"key":"bibr14-20363613231164017","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-200111"},{"key":"bibr15-20363613231164017","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S163141"},{"issue":"1","key":"bibr16-20363613231164017","first-page":"7","volume":"41","author":"Bruce DM","year":"1996","journal-title":"J R Coll Surg Edinb"},{"key":"bibr17-20363613231164017","doi-asserted-by":"publisher","DOI":"10.1136\/thx.19.3.251"},{"key":"bibr18-20363613231164017","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2019.1595982"},{"key":"bibr19-20363613231164017","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b21c7b"},{"key":"bibr20-20363613231164017","doi-asserted-by":"publisher","DOI":"10.1159\/000111096"},{"key":"bibr21-20363613231164017","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.42.6635"}],"container-title":["Rare Tumors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20363613231164017","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20363613231164017","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20363613231164017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:11:17Z","timestamp":1777590677000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20363613231164017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,13]]},"references-count":21,"alternative-id":["10.1177\/20363613231164017"],"URL":"https:\/\/doi.org\/10.1177\/20363613231164017","relation":{},"ISSN":["2036-3613","2036-3613"],"issn-type":[{"value":"2036-3613","type":"print"},{"value":"2036-3613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,13]]},"article-number":"20363613231164017"}}