{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:28:53Z","timestamp":1789565333184,"version":"build-2803163510"},"reference-count":13,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rare Tumors"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>Introduction: Primary cutaneous CD8+ acral T-cell lymphoproliferative disorder (CD8+ ATCLPD) is a rare form of cutaneous T-cell lymphoma that commonly presents on the acral regions of the body. We report a case of a 61-year-old man diagnosed with primary cutaneous CD8+ ATCLPD of the ear. Case presentation: A 61-year-old man presented with a non-healing, erythematous painful macule on the ear that had been evolving for the past 3\u00a0months. The lesion was resected, and histopathological examination revealed a primary cutaneous CD8+ ATCLPD with acral localization. Further investigations including CT scan of the thorax, abdomen and pelvis were done to stage the disease. The results showed no extracutaneous involvement. Conclusion: Accurate identification of primary cutaneous CD8+ ATCLPD is crucial due to its distinct prognostic and therapeutic implications compared to other CD8+ cytotoxic lymphoid proliferations. Primary cutaneous CD8+ ATCLPD can be treated conservatively and typically follows a slow clinical course, regardless of the treatment method. Understanding the clinical context, as well as the morphological and immunophenotypic characteristics, can assist in making a precise diagnosis.<\/jats:p>","DOI":"10.1177\/20363613231204046","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T10:07:07Z","timestamp":1695377227000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The enigmatic ear: Unveiling a rare case of a primary cutaneous CD8+ acral T-cell lymphoproliferative disorder with a literature review"],"prefix":"10.1177","volume":"15","author":[{"given":"Ghada","family":"Sahraoui","sequence":"first","affiliation":[{"name":"Department of Pathology, Salah Azaiez Institute of Cancer, Tunis, Tunisia"},{"name":"Research Laboratory LR21SP01, Salah Azaiez Institute, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2078-6795","authenticated-orcid":false,"given":"Farah","family":"Sassi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Salah Azaiez Institute of Cancer, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamia","family":"Charfi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Salah Azaiez Institute of Cancer, Tunis, Tunisia"},{"name":"Research Laboratory LR21SP01, Salah Azaiez Institute, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoudha","family":"Doghri","sequence":"additional","affiliation":[{"name":"Department of Pathology, Salah Azaiez Institute of Cancer, Tunis, Tunisia"},{"name":"Research Laboratory LR21SP01, Salah Azaiez Institute, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karima","family":"Mrad","sequence":"additional","affiliation":[{"name":"Department of Pathology, Salah Azaiez Institute of Cancer, Tunis, Tunisia"},{"name":"Research Laboratory LR21SP01, Salah Azaiez Institute, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,9,22]]},"reference":[{"key":"bibr1-20363613231204046","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015851"},{"key":"bibr2-20363613231204046","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01620-2"},{"key":"bibr3-20363613231204046","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11020634"},{"key":"bibr4-20363613231204046","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12633"},{"key":"bibr5-20363613231204046","volume-title":"Skin lymphoma: the illustrated guide","edition":"4"},{"key":"bibr6-20363613231204046","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2017-0230-RA"},{"key":"bibr7-20363613231204046","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12045"},{"key":"bibr8-20363613231204046","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31825c3a33"},{"key":"bibr9-20363613231204046","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12213"},{"key":"bibr10-20363613231204046","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2009.01278.x"},{"key":"bibr11-20363613231204046","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318068b527"},{"key":"bibr12-20363613231204046","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13628"},{"key":"bibr13-20363613231204046","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01613-1"}],"container-title":["Rare Tumors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20363613231204046","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20363613231204046","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20363613231204046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:11:28Z","timestamp":1777590688000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20363613231204046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":13,"alternative-id":["10.1177\/20363613231204046"],"URL":"https:\/\/doi.org\/10.1177\/20363613231204046","relation":{},"ISSN":["2036-3613","2036-3613"],"issn-type":[{"value":"2036-3613","type":"print"},{"value":"2036-3613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4]]},"article-number":"20363613231204046"}}