{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:02:29Z","timestamp":1787770949556,"version":"build-2784847793"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Ministry of Healthcare of the Republic of Kazakhstan","award":["BR11065390 \"Design and development of innovative technologies for early diagnostics and treatment of malignant diseases, taking into account modern approaches of genomics\""],"award-info":[{"award-number":["BR11065390 \"Design and development of innovative technologies for early diagnostics and treatment of malignant diseases, taking into account modern approaches of genomics\""]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rare Tumors"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:p>The purpose of this study was to analyze the outcomes of extracranial GCT in children in a developing country and to assess prognostic factors. The data on 141 children (&lt;18\u00a0years old) with extracranial GCT, confirmed histopathologically, collected over the past 9\u00a0years (from February 2013 to June 2022) were retrospectively studied. The patients underwent the same therapy with platinum-containing chemotherapy regimens. In the malignant GCT group, OS and EFS were 81.0 \u00b1 4% and 73 \u00b1 5%, respectively. OS and EFS in the teratoma group were 90 \u00b1 5% and 85 \u00b1 6%. In univariate analysis, parameters like stage of disease, tumor localization, AFP level \u226510,000\u00a0ng\/mL, serum AFP kinetics and resection status were found to be statistically significant prognostic factors. In the multivariate analysis, the significant adverse factors were the resection status, initial AFP level \u226510,000\u00a0ng\/mL and serum AFP kinetics slow down ( p = .000). Good survival rates can be achieved in developing countries with adequate compliance with treatment protocols. The analysis demonstrates high efficacy of platinum-containing chemotherapy regimens. In our opinion, the protocol used in high-income countries can be implemented in low-income countries with the financial support from the government. The qualification of specialists is also important.<\/jats:p>","DOI":"10.1177\/20363613231216567","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T08:20:16Z","timestamp":1711959616000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Outcomes of pediatric extracranial germ cell tumors: A single center experience in a developing country"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0262-8515","authenticated-orcid":false,"given":"Symbat","family":"Saliyeva","sequence":"first","affiliation":[{"name":"Oncology\/hematology Department, Scientific Center of Pediatrics and Pediatric Surgery, Almaty, Kazakhstan"},{"name":"Department of Children's Diseases, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riza","family":"Boranbayeva","sequence":"additional","affiliation":[{"name":"Oncology\/hematology Department, Scientific Center of Pediatrics and Pediatric Surgery, Almaty, Kazakhstan"},{"name":"Department of Children's Diseases, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minira","family":"Bulegenova","sequence":"additional","affiliation":[{"name":"Oncology\/hematology Department, Scientific Center of Pediatrics and Pediatric Surgery, Almaty, Kazakhstan"},{"name":"Department of Children's Diseases, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bakhram","family":"Zhumadullayev","sequence":"additional","affiliation":[{"name":"Oncology\/hematology Department, Scientific Center of Pediatrics and Pediatric Surgery, Almaty, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaukhar","family":"Nurzhanova","sequence":"additional","affiliation":[{"name":"Oncology\/hematology Department, Scientific Center of Pediatrics and Pediatric Surgery, Almaty, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyazat","family":"Manzhuova","sequence":"additional","affiliation":[{"name":"Oncology\/hematology Department, Scientific Center of Pediatrics and Pediatric Surgery, Almaty, Kazakhstan"},{"name":"Department of Children's Diseases, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,1]]},"reference":[{"issue":"5","key":"bibr1-20363613231216567","first-page":"265","volume":"76","author":"Zubizarreta P","year":"2016","journal-title":"MEDICINA (B.Aires)"},{"key":"bibr2-20363613231216567","doi-asserted-by":"publisher","DOI":"10.24953\/turkjped.2017.04.007"},{"key":"bibr3-20363613231216567","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28812"},{"key":"bibr4-20363613231216567","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2019.05.001"},{"key":"bibr5-20363613231216567","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0178-9"},{"key":"bibr6-20363613231216567","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020258"},{"key":"bibr7-20363613231216567","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1568"},{"key":"bibr8-20363613231216567","doi-asserted-by":"publisher","DOI":"10.10.1002\/pbc.25423"},{"key":"bibr9-20363613231216567","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-013-3384-7"},{"key":"bibr10-20363613231216567","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedsurg.2005.10.022"},{"key":"bibr11-20363613231216567","unstructured":"National Cancer Institute. https:\/\/www.cancer.gov 2021. 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