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HDS2 was shown to act as an NNRTI by qPCR and in\u00a0vitro enzyme assays. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> This compound provides a new scaffold for further optimization of activity through structure-guided design. <\/jats:p><\/jats:sec>","DOI":"10.1177\/2040206614566580","type":"journal-article","created":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T17:01:37Z","timestamp":1426525297000},"page":"28-38","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Identification of a dibenzocyclooctadiene lignan as a HIV-1 non-nucleoside reverse transcriptase inhibitor"],"prefix":"10.1177","volume":"24","author":[{"given":"Ying-Shan","family":"Han","sequence":"first","affiliation":[{"name":"McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, 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