{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:28:51Z","timestamp":1778657331559,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"3-4","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antivir Chem Chemother"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Influenza is a disease of significant morbidity and mortality, the number of anti-influenza drugs is small; many of them stimulate the appearance of resistant strains. In this work, we demonstrate activity of some usnic acid (UA) derivatives against influenza virus in\u00a0vitro and in\u00a0vivo . <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Organic synthesis was used to prepare compounds. Antiviral activity of the compounds in\u00a0vitro was evaluated by their ability to decrease the virus titer on Madin\u2013Darby Canine Kidney cells. In\u00a0vivo activity was evaluated by decrease of mortality and index of protection. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Compounds were tested against a broad spectrum of influenza virus strains and showed activity against all used strains. One compound, [5] (valine enamine of UA), also significantly reduced lethality of infected animals and does not give rise to the appearance of resistant strains. Additional studies showed that hepatotoxicity of compound [5] is reduced comparatively to UA. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Our results suggest that valine enamine of UA could be a potential candidate for the development of a new anti-influenza therapy. <\/jats:p><\/jats:sec>","DOI":"10.1177\/2040206616636992","type":"journal-article","created":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T00:34:18Z","timestamp":1459211658000},"page":"92-98","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Derivatives of usnic acid inhibit broad range of influenza viruses and protect mice from lethal influenza infection"],"prefix":"10.1177","volume":"24","author":[{"given":"AA","family":"Shtro","sequence":"first","affiliation":[{"name":"Influenza Research Institute, Laboratory of Antiviral Chemotherapy, Saint-Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VV","family":"Zarubaev","sequence":"additional","affiliation":[{"name":"Influenza Research Institute, Laboratory of Antiviral Chemotherapy, Saint-Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"OA","family":"Luzina","sequence":"additional","affiliation":[{"name":"Novosibirsk Institute of Organic Chemistry, Department of Medical Chemistry, Novosibirsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DN","family":"Sokolov","sequence":"additional","affiliation":[{"name":"Novosibirsk Institute of Organic Chemistry, Department of Medical Chemistry, Novosibirsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NF","family":"Salakhutdinov","sequence":"additional","affiliation":[{"name":"Novosibirsk Institute of Organic Chemistry, Department of Medical Chemistry, Novosibirsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,7,8]]},"reference":[{"key":"bibr1-2040206616636992","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00105.2013"},{"key":"bibr2-2040206616636992","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(97)00061-2"},{"key":"bibr3-2040206616636992","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12046"},{"key":"bibr4-2040206616636992","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2012.09.013"},{"key":"bibr5-2040206616636992","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040842"},{"key":"bibr6-2040206616636992","unstructured":"Centers for Disease Control and Prevention (CDC). Update: influenza activity\u2013United States, 2 October\u201326 November, http:\/\/www.cdc.gov\/mmwr\/preview\/mmwrhtml\/mm6048a2.htm (2011, accessed 19 February 2016)."},{"key":"bibr7-2040206616636992","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.03.014"},{"key":"bibr8-2040206616636992","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.09.084"},{"key":"bibr9-2040206616636992","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2014.10.033"},{"key":"bibr10-2040206616636992","unstructured":"Salakhutdinov NF, Polovinka MP and Panchenko MY. RF Patent 2, 317, 076C1; Byull. Izobret., 2008, No. 5. 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