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Inhibitors of tick-borne encephalitis virus (TBEV) strain Absettarov, presumably targeting E protein n-octyl-\u03b2-d-glucoside (\u03b2-OG) pocket, were reported earlier. In this work, these inhibitors were tested in vitro against seven strains representing three main TBEV subtypes. The most potent compound, 2-[(2-methyl-1-oxido-5,6,7,8-tetrahydroquinazolin-4-yl)amino]-phenol, showed EC<jats:sub>50<\/jats:sub> values lower than 22\u2009\u00b5M against all the tested strains. Nevertheless, EC<jats:sub>50<\/jats:sub> values for virus samples of certain strains demonstrated a substantial variation, which appeared to be consistent with the presence of E protein not only in infectious virions, but also in non-infectious and immature virus particles, protein aggregates, and membrane complexes. <\/jats:p>","DOI":"10.1177\/2040206620943462","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T04:55:17Z","timestamp":1597812917000},"page":"204020662094346","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Spectrum of antiviral activity of 4-aminopyrimidine <i>N<\/i>-oxides against a broad panel of tick-borne encephalitis virus strains"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8399-5944","authenticated-orcid":false,"given":"Evgenia V","family":"Dueva","sequence":"first","affiliation":[{"name":"FSBSI 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