{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:01:52Z","timestamp":1777878112940,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Hematology"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:p>Background: We herein report the long-term results of an allogeneic reduced-intensity conditioning (allo-RIC) protocol used in 21 consecutive patients (16 males, median age 56 years, 71% in complete remission) diagnosed with mantle cell lymphoma (MCL).<\/jats:p>\n                  <jats:p>\n                    Methods: The allo-RIC consisted of fludarabine plus melphalan and peripheral blood hematopoietic stem cells (PBSCs) from human leukocyte antigen (HLA)-identical siblings were used in all cases. Median CD34+ infused cells was 5.8\u2009\u00d7\u200910\n                    <jats:sup>6<\/jats:sup>\n                    \/kg. All patients engrafted promptly.\n                  <\/jats:p>\n                  <jats:p>Results: Early toxicity included mild\/moderate mucositis (43%), febrile neutropenia (33%) and bacterial infections (19%). With a median follow up of 48 months, four deaths were reported, all due to infections and\/or graft- versus-host disease (GVHD), yielding a 3-year cumulative incidence of nonrelapse mortality of 19.5%. Grade III\u2013IV acute GVHD occurred in 15% and chronic GVHD in 78%, being extensive in 39%. The 5-year progression-free survival (PFS) and overall survival (OS) were both 80% (95% CI: 63\u201397%). Age was the only possible prognostic factor for OS, which was 43% for those aged more than 60 years and 100% for those younger ( p\u2009&lt;\u20090.001).<\/jats:p>\n                  <jats:p>Conclusions: Our data confirm that allo-RIC offers a low toxicity profile and a chance for prolonged long-term disease-free survival in MCL, particularly in younger patients.<\/jats:p>","DOI":"10.1177\/2040620710396752","type":"journal-article","created":{"date-parts":[[2011,2,7]],"date-time":"2011-02-07T12:36:48Z","timestamp":1297082208000},"page":"5-10","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Long-term results of fludarabine\/melphalan as a reduced-intensity conditioning regimen in mantle cell lymphoma: the GELTAMO experience"],"prefix":"10.1177","volume":"2","author":[{"given":"Jorge","family":"Gayoso","sequence":"first","affiliation":[{"name":"Servicio de Hematolog\u00eda-UTMO, HGU Gregorio Mara\u00f1\u00f3n, c\/Maiquez, 7, Madrid 28009, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Martino","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital Santa Creu i Sant Pau, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascual","family":"Balsalobre","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada","family":"Heras","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital Morales Messeguer, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Luis","family":"Pi\u00f1ana","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital Santa Creu i Sant Pau, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Serrano","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier de la","family":"Serna","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital Doce de Octubre, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Francisco","family":"Tom\u00e1s","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, MD Anderson Espa\u00f1a, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Luis","family":"D\u00edez-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores","family":"Caballero","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital Cl\u00ednico de Salamanca, Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,2,7]]},"reference":[{"key":"bibr1-2040620710396752","doi-asserted-by":"publisher","DOI":"10.1016\/S1083-8791(03)70005-6"},{"key":"bibr2-2040620710396752","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705008"},{"key":"bibr3-2040620710396752","first-page":"2318","volume":"104","author":"Caballero M.D.","year":"2004","journal-title":"ASH Annual Meeting Abstracts"},{"key":"bibr4-2040620710396752","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404822"},{"key":"bibr5-2040620710396752","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1182\/blood-2004-10-3883","volume":"105","author":"Dreyling 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