{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:02:16Z","timestamp":1777878136075,"version":"3.51.4"},"reference-count":75,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,7,11]],"date-time":"2012-07-11T00:00:00Z","timestamp":1341964800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Hematology"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>Arterial and venous thromboembolic diseases are a clinical and economic burden worldwide. In addition to traditional agents such as vitamin K antagonists and heparins, newer oral agents \u2013 such as the factor Xa inhibitors rivaroxaban, apixaban, and edoxaban, and the direct thrombin inhibitor dabigatran \u2013 have been shown to be effective across several indications. Rivaroxaban has been shown to have predictable pharmacokinetic and pharmacodynamic properties, including a rapid onset of action. In addition, there is no requirement for routine coagulation monitoring; and no dose adjustment is necessary for age alone, sex, or body weight. Rivaroxaban has successfully met primary efficacy and safety endpoints in large, randomized phase III trials across several indications, including: prevention of venous thromboembolism in orthopedic patients undergoing elective hip or knee replacement surgery; treatment of deep vein thrombosis and secondary prevention of deep vein thrombosis and pulmonary embolism; stroke prevention in patients with atrial fibrillation; and secondary prevention of acute coronary syndrome. Rivaroxaban and the other newer oral anticoagulants are likely to improve outcomes in the prevention and treatment of thromboembolic events, and will offer patients and physicians alternative treatment options.<\/jats:p>","DOI":"10.1177\/2040620712453067","type":"journal-article","created":{"date-parts":[[2012,7,12]],"date-time":"2012-07-12T00:55:01Z","timestamp":1342054501000},"page":"309-323","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Advances in oral anticoagulation treatment: the safety and efficacy of rivaroxaban in the prevention and treatment of thromboembolism"],"prefix":"10.1177","volume":"3","author":[{"given":"Alexander G.G.","family":"Turpie","sequence":"first","affiliation":[{"name":"McMaster University, Hamilton General Hospital, Hamilton Health Sciences-McMaster Clinic, 237 Barton Street East, Hamilton, ON, Canada L8L 2X2"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,7,11]]},"reference":[{"key":"bibr1-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.668020"},{"key":"bibr2-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi485"},{"key":"bibr3-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0670"},{"key":"bibr4-2040620712453067","unstructured":"Bayer Pharma AG (2011) Xarelto\n                      \u00ae\n                      (rivaroxaban) Summary of Product Characteristics. Available at: http:\/\/www.xarelto.com\/html\/downloads\/Xarelto_Summary_of_Product_Characteristics_Dec2011.pdf (accessed 4 May 2012)."},{"key":"bibr5-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199609053351002"},{"key":"bibr6-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-05-160143"},{"key":"bibr7-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq278"},{"key":"bibr8-2040620712453067","first-page":"576","volume":"9","author":"Chan H.","year":"2011","journal-title":"J Thromb Haemost"},{"key":"bibr9-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1160\/TH07-03-0212"},{"key":"bibr10-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-011-0549-x"},{"key":"bibr11-2040620712453067","unstructured":"Cohen A., Spiro T., B\u00fcller H., Haskell L., Hu D., Hull R. (2011b) Rivaroxaban compared with enoxaparin for the prevention of venous thromboembolism in acutely ill medical patients. Available at: http:\/\/my.americanheart.org\/idc\/groups\/ahamah-public\/@wcm\/@sop\/@scon\/documents\/downloadable\/ucm_425442.pdf (accessed 25 April 2012)."},{"key":"bibr12-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905561"},{"key":"bibr13-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-120543"},{"key":"bibr14-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21917"},{"key":"bibr15-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.029017"},{"key":"bibr16-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.642074"},{"key":"bibr17-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0800374"},{"key":"bibr18-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02748.x"},{"key":"bibr19-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61445-7"},{"key":"bibr20-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.91B5.21691"},{"key":"bibr21-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr342"},{"key":"bibr22-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0656"},{"key":"bibr23-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.1_suppl.132S"},{"key":"bibr24-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110899"},{"key":"bibr25-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1378\/chest.1412S3"},{"key":"bibr26-2040620712453067","volume":"33","author":"Harder S.","year":"2004","journal-title":"Pathophysiol Haemost Thromb"},{"key":"bibr27-2040620712453067","volume":"106","author":"Heit J.","year":"2005","journal-title":"Blood (ASH Annual Meeting Abstracts)"},{"key":"bibr28-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0689"},{"key":"bibr29-2040620712453067","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-153-1-201007060-00004"},{"key":"bibr30-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-010-0500-6"},{"key":"bibr31-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60880-6"},{"key":"bibr32-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0658"},{"key":"bibr33-2040620712453067","first-page":"162","volume":"18","author":"Khurram Z.","year":"2006","journal-title":"J Invasive Cardiol"},{"key":"bibr34-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2010.03753.x"},{"key":"bibr35-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1177\/0091270006292127"},{"key":"bibr36-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2006.02776.x"},{"key":"bibr37-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1185\/03007990802361499"},{"key":"bibr38-2040620712453067","volume":"3","author":"Kubitza D.","year":"2005","journal-title":"J Thromb Haemost"},{"key":"bibr39-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.06.011"},{"key":"bibr40-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-005-0043-5"},{"key":"bibr41-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa076016"},{"key":"bibr42-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1006885"},{"key":"bibr43-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)62125-5"},{"key":"bibr44-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000150640.98772.af"},{"key":"bibr45-2040620712453067","first-page":"208694","volume":"2011","author":"Lemmens R.","year":"2011","journal-title":"Stroke Res Treat"},{"key":"bibr46-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e3181f2f264"},{"key":"bibr47-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.929"},{"key":"bibr48-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192667"},{"key":"bibr49-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60738-8"},{"key":"bibr50-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1112277"},{"key":"bibr51-2040620712453067","first-page":"135","volume":"9","author":"Morishima Y.","year":"2011","journal-title":"J Thromb Haemost"},{"key":"bibr52-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07492-2"},{"key":"bibr53-2040620712453067","first-page":"S103","volume":"9","author":"Nutescu E.","year":"2003","journal-title":"Am J Manag Care"},{"key":"bibr54-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009638"},{"key":"bibr55-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2002.122027"},{"key":"bibr56-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01166.x"},{"key":"bibr57-2040620712453067","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10516"},{"key":"bibr58-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjr.0000359235.59808.ba"},{"key":"bibr59-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.080493"},{"key":"bibr60-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1112770"},{"key":"bibr61-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182009701"},{"key":"bibr62-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2010.09.008"},{"key":"bibr63-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-06-0391"},{"key":"bibr64-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2011.134"},{"key":"bibr65-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-03-0176"},{"key":"bibr66-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007903"},{"key":"bibr67-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1113572"},{"key":"bibr68-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60734-0"},{"key":"bibr69-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-09-0601"},{"key":"bibr70-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904327"},{"key":"bibr71-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0673"},{"key":"bibr72-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706482"},{"key":"bibr73-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.8.983"},{"key":"bibr74-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010746"},{"key":"bibr75-2040620712453067","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.624650"}],"container-title":["Therapeutic Advances in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2040620712453067","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2040620712453067","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2040620712453067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:12:41Z","timestamp":1777590761000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2040620712453067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,11]]},"references-count":75,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1177\/2040620712453067"],"URL":"https:\/\/doi.org\/10.1177\/2040620712453067","relation":{},"ISSN":["2040-6207","2040-6215"],"issn-type":[{"value":"2040-6207","type":"print"},{"value":"2040-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,11]]}}}