{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:25:21Z","timestamp":1791181521584,"version":"4.1.0"},"reference-count":65,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,3,25]],"date-time":"2013-03-25T00:00:00Z","timestamp":1364169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Hematology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p>The identification of patients at high risk of relapse is a critical goal of modern translational research in oncohematology. Minimal residual disease (MRD) detection by polymerase chain reaction-based methods is routinely employed in the management of patients with acute lymphoblastic leukemia. Current knowledge indicates that it is also a useful prognostic tool in several mature lymphoproliferative disorders and particularly in follicular lymphoma (FL). Based on this evidence clinical trials employing MRD-based risk stratification are currently ongoing in FL. In this review the \u2018state of the art\u2019 of MRD evaluation in FL is discussed. A short description of technical issues and recent methodological advances is provided. Then, the bulk of the review focuses on critical take-home messages for clinicians working in the field. Finally, we discuss future perspectives of MRD detection and more generally outcome prediction in FL.<\/jats:p>","DOI":"10.1177\/2040620713480522","type":"journal-article","created":{"date-parts":[[2013,3,25]],"date-time":"2013-03-25T23:27:02Z","timestamp":1364254022000},"page":"189-198","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Clinical implications and prognostic role of minimal residual disease detection in follicular lymphoma"],"prefix":"10.1177","volume":"4","author":[{"given":"Chiara","family":"Lobetti-Bodoni","sequence":"first","affiliation":[{"name":"Hematology Division I, Azienda ospedaliera San Giovanni Battista, Citt\u00e0 della Salute e della Scienza, Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Mantoan","sequence":"additional","affiliation":[{"name":"Hematology Division I, Azienda ospedaliera San Giovanni Battista, Citt\u00e0 della 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