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Initial phase I and II clinical trials of lenalidomide alone and as part of combination regimens in patients with relapsed\/refractory MCL have shown promising results. Its immunomodulatory, T cell costimulatory, anti-inflammatory and anti-angiogenic actions working together in the tumor cell microenvironment seem to be responsible for its enhanced antitumor efficacy. Lenalidomide\u2019s nature of action and safety profile favor it over other agents studied in relapsed\/refractory MCL. This review summarizes the data from preclinical and clinical studies of lenalidomide in relapsed\/refractory MCL and compares the results with those of other novel agents being used for relapsed\/refractory MCL.<\/jats:p>","DOI":"10.1177\/2040620714532124","type":"journal-article","created":{"date-parts":[[2014,4,29]],"date-time":"2014-04-29T23:17:08Z","timestamp":1398813428000},"page":"91-101","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Lenalidomide in relapsed or refractory mantle cell lymphoma: overview and perspective"],"prefix":"10.1177","volume":"5","author":[{"given":"Madhav","family":"Desai","sequence":"first","affiliation":[{"name":"Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"},{"name":"Department of Internal Medicine, The University of Kansas Medical Center, Kansas City, KS, 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