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Watchful waiting is a reasonable approach for asymptomatic patients especially in elderly. In symptomatic patients, treatment is chemo-immunotherapy followed by maintenance immunotherapy or autologous bone marrow transplant. Allogeneic bone marrow transplant has a potential benefit of cure for relapsed\/refractory cases, but it has a high mortality rate. Novel treatment with agents such as ibrutinib, a Bruton tyrosine kinase inhibitor, has shown promising results in relapse\/refractory cases. We extensively review the most recent data on diagnostic and therapeutic management of mantle cell lymphoma through presenting two extreme clinical scenarios.<\/jats:p>","DOI":"10.1177\/2040620714561579","type":"journal-article","created":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T21:46:10Z","timestamp":1418075170000},"page":"37-48","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Mantle cell lymphoma: observation to transplantation"],"prefix":"10.1177","volume":"6","author":[{"given":"Babak","family":"Rajabi","sequence":"first","affiliation":[{"name":"University of Nevada School of Medicine, 2040 West Charleston Boulevard, Las Vegas, NV 89102, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Sweetenham","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 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