{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:54:43Z","timestamp":1791251683371,"version":"4.1.0"},"reference-count":47,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T00:00:00Z","timestamp":1482278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Hematology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>Paroxysmal nocturnal haemoglobinuria (PNH), an ultra-orphan disease with a prevalence of 15.9 per million in Europe, is a life-threatening disorder, characterized by haemolysis, bone marrow failure and thrombosis. Patients with PNH prior to the availability of eculizumab had a median survival of between 10 and 22 years, with thrombosis accounting for 22\u201367% of deaths. 29\u201344% of patients had at least one thrombosis. This paper provides a clinician\u2019s guide to the diagnosis, management and complications of PNH, with an emphasis on thrombosis.<\/jats:p>","DOI":"10.1177\/2040620716681748","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T07:18:49Z","timestamp":1486711129000},"page":"119-126","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":55,"title":["Management of thrombosis in paroxysmal nocturnal hemoglobinuria: a clinician\u2019s guide"],"prefix":"10.1177","volume":"8","author":[{"given":"Morag","family":"Griffin","sequence":"first","affiliation":[{"name":"Leeds Teaching Hospitals NHS Trust, St James Hospital, Beckett Street, Leeds LS1 3EX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talha","family":"Munir","sequence":"additional","affiliation":[{"name":"Leeds Teaching Hospitals NHS Trust, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,12,21]]},"reference":[{"key":"bibr1-2040620716681748","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.049767"},{"key":"bibr2-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2003.tb00260.x"},{"key":"bibr3-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06240.x"},{"key":"bibr4-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04562.x"},{"key":"bibr5-2040620716681748","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/cyto.b.20525","volume":"78","author":"Borowitz M.","year":"2010","journal-title":"Cytometry B Clin Cytom"},{"key":"bibr6-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-094136"},{"key":"bibr7-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041497"},{"key":"bibr8-2040620716681748","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.037531"},{"key":"bibr9-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-133918"},{"key":"bibr10-2040620716681748","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.062828"},{"key":"bibr11-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.21368"},{"key":"bibr12-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-01-0009"},{"key":"bibr13-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199001000-00007"},{"key":"bibr14-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-311381"},{"key":"bibr15-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08096.x"},{"key":"bibr16-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2012.09166.x"},{"key":"bibr17-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031688"},{"key":"bibr18-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199511093331904"},{"key":"bibr19-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-095646"},{"key":"bibr20-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12347"},{"key":"bibr21-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061648"},{"key":"bibr22-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.06.019"},{"key":"bibr23-2040620716681748","doi-asserted-by":"crossref","unstructured":"Hoffbrand V., Tuddenham G., Green A. (2011) Postgraduate Haematology, Sixth Edition. Chapter 11, Blackwell Publishing.","DOI":"10.1002\/9781444323160"},{"key":"bibr24-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1502950"},{"key":"bibr25-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-333997"},{"key":"bibr26-2040620716681748","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S3334"},{"key":"bibr27-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1097\/01.RVI.0000196338.87954.CE"},{"key":"bibr28-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2015.04.006"},{"key":"bibr29-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24278"},{"key":"bibr30-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.3.310"},{"key":"bibr31-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1994.tb01037.x"},{"key":"bibr32-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000362"},{"key":"bibr33-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199401273300404"},{"key":"bibr34-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04992.x"},{"key":"bibr35-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V82.4.1192.1192"},{"key":"bibr36-2040620716681748","first-page":"103","volume":"30","author":"Ray J.","year":"2000","journal-title":"Haemostasis"},{"key":"bibr37-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V60.1.20.20"},{"key":"bibr38-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.13.1653"},{"key":"bibr39-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01195.x"},{"key":"bibr40-2040620716681748","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.093161"},{"key":"bibr41-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04974.x"},{"key":"bibr42-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(88)80092-5"},{"key":"bibr43-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21714"},{"key":"bibr44-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)12360-1"},{"key":"bibr45-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.21023"},{"key":"bibr46-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1007\/BF03165111"},{"key":"bibr47-2040620716681748","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02379.x"}],"container-title":["Therapeutic Advances in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2040620716681748","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2040620716681748","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2040620716681748","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:13:51Z","timestamp":1777590831000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2040620716681748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,21]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1177\/2040620716681748"],"URL":"https:\/\/doi.org\/10.1177\/2040620716681748","relation":{},"ISSN":["2040-6207","2040-6215"],"issn-type":[{"value":"2040-6207","type":"print"},{"value":"2040-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,21]]}}}