{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:03:42Z","timestamp":1777878222067,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Hematology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Joint bleeds are the hallmark of haemophilia, and can lead to disabling haemophilic arthropathy. Consequently, the movement behaviour of adults with haemophilia differs from that of healthy adults. It seems unlikely that a single outcome is able to reflect all relevant information regarding movement behaviour. The aim of the current study was to identify patterns of movement behaviour within persons with haemophilia (PWH) and compare clinical characteristics between patterns of movement behaviour.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 105 PWH [70% severe haemophilia; median age 43\u2009years (30.0\u201354.0)] were included in the study. Hierarchical cluster analysis was used to identify patterns of movement behaviour. Clustering variables included seven parameters of movement behaviour: sitting, standing, walking, biking, running, frequency of active bouts and length of active bouts. Clinical characteristics included age, severity of haemophilia, joint health, physical functioning and pain. Clinical characteristics were compared between identified clusters by Kruskall\u2013Wallis test. Movement behaviour was assessed with the Activ8 accelerometer, joint health was assessed on the Haemophilia Joint Health Score, physical functioning on the Haemophilia Activity List and the 40\u2009m self-paced walk test and pain on the Numerical Pain Rating Score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Cluster analysis identified three clusters, which were defined as: \u2018sedentary\u2019 (57%), \u2018bikers and runners\u2019 (22%) and \u2018walkers\u2019 (20%). The \u2018bikers and runners\u2019 showed better joint health and experienced fewer limitations in activities than the \u2018walkers\u2019 and the \u2018sedentary\u2019. The \u2018walkers\u2019 perceived fewer limitations in activities than the \u2018sedentary\u2019, with comparable joint health. We did not identify differences in pain, walking speed and age between the clusters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>We identified three patterns of movement behaviour. The majority of PWH was identified as sedentary, whereas less sitting and regular walking during the day seemed to be more beneficial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2040620719896959","type":"journal-article","created":{"date-parts":[[2020,3,14]],"date-time":"2020-03-14T01:43:53Z","timestamp":1584150233000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Movement behaviour patterns in adults with haemophilia"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1910-999X","authenticated-orcid":false,"given":"Merel A.","family":"Timmer","sequence":"first","affiliation":[{"name":"Van Creveldkliniek, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, the Netherlands"},{"name":"Physical Therapy Research, Department of Rehabilitation, Physical Therapy Science and Sport, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Veenhof","sequence":"additional","affiliation":[{"name":"Physical Therapy Research, Department of Rehabilitation, Physical Therapy Science and Sport, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands"},{"name":"Research Group Innovation of Human Movement Care, University of Applied Sciences Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piet","family":"de Kleijn","sequence":"additional","affiliation":[{"name":"Van Creveldkliniek, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob A.","family":"de Bie","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger E. G.","family":"Schutgens","sequence":"additional","affiliation":[{"name":"Van Creveldkliniek, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martijn F.","family":"Pisters","sequence":"additional","affiliation":[{"name":"Centre for Physical Therapy Research and Innovation in Primary Care, Julius Health Care Centres, Utrecht University, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,3,13]]},"reference":[{"key":"bibr1-2040620719896959","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07386.x"},{"key":"bibr2-2040620719896959","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-37938"},{"key":"bibr3-2040620719896959","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13441"},{"key":"bibr4-2040620719896959","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.12.007"},{"key":"bibr5-2040620719896959","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1999.00608.x"},{"key":"bibr6-2040620719896959","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000000473"},{"key":"bibr7-2040620719896959","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2014.302540"},{"key":"bibr8-2040620719896959","first-page":"CD011180","volume":"12","author":"Strike K","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr9-2040620719896959","doi-asserted-by":"publisher","DOI":"10.1186\/s12966-017-0525-8"},{"key":"bibr10-2040620719896959","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02469.x"},{"key":"bibr11-2040620719896959","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12134"},{"key":"bibr12-2040620719896959","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056427"},{"key":"bibr13-2040620719896959","doi-asserted-by":"publisher","DOI":"10.7326\/M14-1651"},{"key":"bibr14-2040620719896959","unstructured":"Activ8. VitaMove, https:\/\/www.activ8all.com\/product\/activ8-professional-activity-monitor\/"},{"key":"bibr15-2040620719896959","unstructured":"University Medical Center Rotterdam. Validation of the Active8 Activity Monitor: detection of body postures and movements, https:\/\/www.activ8all.com\/front15\/wp-content\/uploads\/2014\/08\/ReportActiv8_EMC.pdf (2013)."},{"key":"bibr16-2040620719896959","doi-asserted-by":"publisher","DOI":"10.3390\/s18072167"},{"key":"bibr17-2040620719896959","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/pzy152"},{"key":"bibr18-2040620719896959","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000185657.86065.98"},{"key":"bibr19-2040620719896959","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1365-2516.2011.02687.x","volume":"18","author":"Fischer K","year":"2012","journal-title":"Haemophilia"},{"key":"bibr20-2040620719896959","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01312.x"},{"key":"bibr21-2040620719896959","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01203.x"},{"key":"bibr22-2040620719896959","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20538"},{"key":"bibr23-2040620719896959","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.07.005"},{"key":"bibr24-2040620719896959","volume-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2016"},{"key":"bibr25-2040620719896959","author":"M\u00e4chler M","year":"2015","journal-title":"R Package Version 2.0.1"},{"key":"bibr26-2040620719896959","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181620ebc"},{"key":"bibr27-2040620719896959","doi-asserted-by":"publisher","DOI":"10.1160\/TH16-12-0967"},{"key":"bibr28-2040620719896959","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-6-20"}],"container-title":["Therapeutic Advances in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2040620719896959","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2040620719896959","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2040620719896959","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:14:41Z","timestamp":1777590881000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2040620719896959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":28,"alternative-id":["10.1177\/2040620719896959"],"URL":"https:\/\/doi.org\/10.1177\/2040620719896959","relation":{},"ISSN":["2040-6207","2040-6215"],"issn-type":[{"value":"2040-6207","type":"print"},{"value":"2040-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"2040620719896959"}}