{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T15:57:38Z","timestamp":1781366258719,"version":"3.54.1"},"reference-count":19,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["1093704D"],"award-info":[{"award-number":["1093704D"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Hematology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Letermovir prophylaxis is currently the standard of care for the prevention of cytomegalovirus (CMV) infections in allogeneic hematopoietic stem-cell transplantation (allo-HSCT). However, drug\u2013drug interactions between letermovir and azoles or calcineurin inhibitors and the high financial burden of letermovir remain problematic, especially in resource-limited countries. It has not been clarified whether a lower dose of valganciclovir would constitute an effective strategy for CMV prevention in patients with acute leukemia undergoing allo-HSCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We retrospectively assessed 84 consecutive adult patients with acute leukemia who underwent allo-HSCT. These 84 patients were stratified into a valganciclovir prophylaxis group ( n\u2009=\u200920) and a non-valganciclovir prophylaxis group ( n\u2009=\u200964).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Patients in the valganciclovir prophylaxis group had a lower possibility of CMV DNAemia at week 14 after allo-HSCT than those in the non-valganciclovir prophylaxis group (15.0% versus 50.0%; p\u2009=\u20090.012). The cumulative incidence of CMV DNAemia at week 14 was also lower in patients with valganciclovir CMV prophylaxis than in those without (15.0% versus 50.4%; p\u2009=\u20090.006). Multivariate analysis validated these data, showing that a low dose of valganciclovir significantly reduced the risk of CMV DNAemia at week 14 by 88% (hazard ratio: 0.12; 95% confidence interval: 0.04\u20130.42; p\u2009=\u20090.001). However, these two groups had similar overall survival rates at week 48 (75.0% versus 76.6%; p\u2009=\u20090.805). Four of 20 (20%) patients discontinued valganciclovir prophylaxis because of adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Low-dose valganciclovir prophylaxis could be an alternative to letermovir to prevent CMV infection in allo-HSCT, especially in resource-limited countries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2040620721998124","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T02:24:03Z","timestamp":1614824643000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Cytomegalovirus prophylaxis using low-dose valganciclovir in patients with acute leukemia undergoing allogeneic hematopoietic stem-cell transplantation"],"prefix":"10.1177","volume":"12","author":[{"given":"Po-Hsien","family":"Li","sequence":"first","affiliation":[{"name":"Division of Hematology\/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Hsien","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hui","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Taichung Veterans General Hospital, Taichung"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Chih","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung"},{"name":"Graduate Institute of clinical medicine, College of Medicine, National Taiwan University, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiann-Yi","family":"Hsu","sequence":"additional","affiliation":[{"name":"Biostatistics Task Force, Taichung Veterans General Hospital, Taichung"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9744-0368","authenticated-orcid":false,"given":"Chieh-Lin Jerry","family":"Teng","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Blvd., Taichung, 40705"},{"name":"Department of Life Science, Tunghai University, Taichung"},{"name":"School of Medicine, Chung Shan Medical University, Taichung"},{"name":"Division of Hematology\/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung, Department of Life Science, Tunghai University, Taichung School of Medicine, Chung Shan Medical University, Taichung"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,3,3]]},"reference":[{"key":"bibr1-2040620721998124","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-07-604546"},{"key":"bibr2-2040620721998124","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2018.1433030"},{"key":"bibr3-2040620721998124","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(15)00289-6"},{"key":"bibr4-2040620721998124","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30107-0"},{"key":"bibr5-2040620721998124","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018016493"},{"key":"bibr6-2040620721998124","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-118-3-199302010-00004"},{"key":"bibr7-2040620721998124","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(11)70024-X"},{"key":"bibr8-2040620721998124","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1303688"},{"key":"bibr9-2040620721998124","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706640"},{"key":"bibr10-2040620721998124","doi-asserted-by":"publisher","DOI":"10.7326\/M13-2729"},{"key":"bibr11-2040620721998124","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.03.005"},{"key":"bibr12-2040620721998124","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002024"},{"key":"bibr13-2040620721998124","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2012.00723.x"},{"key":"bibr14-2040620721998124","first-page":"603","volume":"15","author":"Lu SC","year":"1999","journal-title":"Kaohsiung J Med Sci"},{"key":"bibr15-2040620721998124","doi-asserted-by":"publisher","DOI":"10.4274\/tjh.2016.0225"},{"key":"bibr16-2040620721998124","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13096"},{"key":"bibr17-2040620721998124","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2015.07.011"},{"key":"bibr18-2040620721998124","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz490"},{"key":"bibr19-2040620721998124","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.10.4063.bloodjournal88104063"}],"container-title":["Therapeutic Advances in 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