{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:01:54Z","timestamp":1792512114819,"version":"4.5.0"},"reference-count":41,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81670197"],"award-info":[{"award-number":["No. 81670197"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81700206"],"award-info":[{"award-number":["No. 81700206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81974007"],"award-info":[{"award-number":["No. 81974007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Hematology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Multiple myeloma (MM) survival has greatly improved in recent decades. MM is usually diagnosed at a median age of 66\u201370 years. MM patients do not necessarily die from primary cancer, so cardiovascular health may be a key factor threatening long-term survival. This study was designed to explore the cardiovascular disease mortality (CVM) trends in MM patients and compare them with those in the general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In total, 88,328 MM patients from the Surveillance, Epidemiology, and End Results (SEER) database (1975\u20132016) were included. Standardized mortality ratios (SMRs) were used to assess CVM risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The CVM risk was significantly higher in MM patients than in the general population (SMR, 1.84 (95% CI, 1.78\u20131.89)). MM patients had the highest CVM SMR, at 2.62 (95% CI, 2.49\u20132.75), in the first year after diagnosis, and it decreased over the follow-up period. Over the study period, the incidence of CVM continued to decrease in MM patients diagnosed at age 65\u201374 (APC, \u22121.2% (95% CI, \u22121.9% to \u22120.4%)) and \u2a7e75 years (APC, \u22121.9% (95% CI, \u22122.6% to \u22121.2%)) but not younger. CVM was the second-most common cause of death in patients \u2a7e75 years. In only MM case analyses, male sex, Black race, older age at diagnosis, and earlier year of diagnosis were poor prognostic factors for heart-specific mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The CVM risk in MM patients was significantly higher than that in the general population. To improve survival, cardiovascular health should receive attention upon diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20406207221086755","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T03:11:02Z","timestamp":1648696262000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Cardiovascular-specific mortality among multiple myeloma patients: a population-based study"],"prefix":"10.1177","volume":"13","author":[{"given":"Xuejiao","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province Key Laboratory of Hematology Oncology Diagnosis and Treatment, Hangzhou, China"},{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8053-025X","authenticated-orcid":false,"given":"Chunyan","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Dadao, Wuhan 430022, 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