{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:36:22Z","timestamp":1791948982591,"version":"4.3.4"},"reference-count":50,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Hematology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>For approximately three decades, autologous hematopoietic cell transplantation (auto-HCT) has been the standard of care for patients with relapsed\/refractory (R\/R) diffuse large B-cell lymphoma (DLBCL) after frontline therapy. This approach is limited due to the intensity of chemotherapy and the proportion of patients who relapse after auto-HCT. Since the approval of anti-CD19 chimeric antigen receptor T-cell (CAR-T) therapy and novel agents, the treatment paradigm for DLBCL has changed remarkably. Anti-CD19 CAR-T therapy was first approved for relapsed DLBCL after two or more previous lines of therapy with long-lasting responses, with over 50% of patients still alive at 5-year follow-up. Here, we discuss recent randomized phase 3 clinical trials using axicabtagene ciloleucel, tisagenlecleucel, and lisocabtagene maraleucel in the second-line therapy setting compared with the standard of care in transplant-eligible patients who have DLBCL R\/R within 12 months of completing chemo-immunotherapy, potentially changing the treatment algorithm for DLBCL.<\/jats:p>","DOI":"10.1177\/20406207221141511","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T04:32:44Z","timestamp":1670301164000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["The role of CAR-T cell therapy as second line in diffuse large B-cell lymphoma"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4802-5445","authenticated-orcid":false,"given":"Omar","family":"Albanyan","sequence":"first","affiliation":[{"name":"Department of Blood and Marrow Transplantation and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, FL, USA"},{"name":"Adult Hematology-Oncology and SCT, King Fahad Specialist Hospital, Dammam 32253, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2045-6238","authenticated-orcid":false,"given":"Julio","family":"Chavez","sequence":"additional","affiliation":[{"name":"Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Munoz","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Mayo Clinic, Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,12,6]]},"reference":[{"key":"bibr1-20406207221141511","unstructured":"National Cancer Institute. Surveillance, epidemiology, and end results (SEER) program. Cancer stat facts: non-Hodgkin lymphoma, https:\/\/seer.cancer.gov\/statfacts\/html\/dlbcl.html"},{"key":"bibr2-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv304"},{"key":"bibr3-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011795"},{"key":"bibr4-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291402"},{"key":"bibr5-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.51.5866"},{"key":"bibr6-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512073332305"},{"key":"bibr7-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.28.1618"},{"key":"bibr8-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.9593"},{"key":"bibr9-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.69.0198"},{"key":"bibr10-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2011.1.498"},{"key":"bibr11-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000102"},{"key":"bibr12-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-03-769620"},{"key":"bibr13-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707447"},{"key":"bibr14-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1804980"},{"key":"bibr15-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31366-0"},{"key":"bibr16-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1914347"},{"key":"bibr17-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00591-X"},{"key":"bibr18-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2021-148078"},{"key":"bibr19-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30864-7"},{"key":"bibr20-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02104"},{"key":"bibr21-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00375-2"},{"key":"bibr22-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2021-148948"},{"key":"bibr23-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003848"},{"key":"bibr24-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2116133"},{"key":"bibr25-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2116596"},{"key":"bibr26-20406207221141511","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1016\/S0140-6736(22)00662-6","volume":"399","author":"Kamdar M","year":"2022","journal-title":"Lancet"},{"key":"bibr27-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00339-4"},{"key":"bibr28-20406207221141511","volume":"2015","author":"Nowakowski GS","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"bibr29-20406207221141511","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1182\/blood-2019-129624","volume":"134","author":"Jain MD","year":"2019","journal-title":"Blood"},{"key":"bibr30-20406207221141511","first-page":"1832","volume":"137","author":"Spiegel JY","year":"2021","journal-title":"Blood"},{"key":"bibr31-20406207221141511","unstructured":"Perales M-A, Kuruvilla J, Snider JT, et al. Cost-effectiveness of axicabtagene ciloleucel as second-line therapy for patients large B-cell lymphoma (LBCL) in the United States. In: 2022 TANDEM meetings transplantation & cellular therapy meetings of ASTCT and CIBMTR, Salt Lake City, UT, 27 April 2022, https:\/\/tandem.confex.com\/tandem\/2022\/meetingapp.cgi\/Paper\/20530"},{"key":"bibr32-20406207221141511","unstructured":"National Comprehensive Cancer Network\u00ae (NCCN Guidelines\u00ae). B-cell lymphomas version 5. 2022, 2022, https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/b-cell.pdf"},{"key":"bibr33-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007939"},{"key":"bibr34-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021013289"},{"key":"bibr35-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.68.2740"},{"key":"bibr36-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01731-4"},{"key":"bibr37-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001797"},{"key":"bibr38-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019004162"},{"key":"bibr39-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17527"},{"key":"bibr40-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2021-150431"},{"key":"bibr41-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2021.11.031"},{"key":"bibr42-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V110.11.1673.1673"},{"key":"bibr43-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2021-146119"},{"key":"bibr44-20406207221141511","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.279999"},{"key":"bibr45-20406207221141511","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.238634"},{"key":"bibr46-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1002\/jha2.350"},{"key":"bibr47-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2021-146038"},{"key":"bibr48-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2021-146045"},{"key":"bibr49-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2021.39.15_suppl.2527"},{"key":"bibr50-20406207221141511","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-021-00920-6"}],"container-title":["Therapeutic Advances in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20406207221141511","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20406207221141511","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20406207221141511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:16:23Z","timestamp":1777590983000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20406207221141511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":50,"alternative-id":["10.1177\/20406207221141511"],"URL":"https:\/\/doi.org\/10.1177\/20406207221141511","relation":{},"ISSN":["2040-6207","2040-6215"],"issn-type":[{"value":"2040-6207","type":"print"},{"value":"2040-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"20406207221141511"}}