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The impressive success has inspired the application of this approach to other types of tumors. The relapsed\/refractory T-cell malignancies are characteristic of high heterogeneity and poor prognoses. The efficacy of current treatments for this group of diseases is limited. CAR-T therapy is a promising solution to ameliorate the current therapeutic situation. One of the major challenges is that normal T-cells typically share mutual antigens with malignant cells, which causes fratricide and serious T-cell aplasia. Moreover, T-cells collected for CAR transduction could be contaminated by malignant T-cells. The selection of suitable target antigens is of vital importance to mitigate fratricide and T-cell aplasia. Using nanobody-derived or naturally selected CAR-T is the latest method to overcome fratricide. Allogeneic CAR-T products and CAR-NK-cells are expected to avoid tumor contamination. Herein, we review the advances in promising target antigens, the current results of CAR-T therapy clinical trials in T-cell malignancies, the obstacles of CAR-T therapy in T-cell malignancies, and the solutions to these issues.<\/jats:p>","DOI":"10.1177\/20406207221143025","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T01:32:40Z","timestamp":1672104760000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Current state of CAR-T therapy for T-cell malignancies"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1757-6992","authenticated-orcid":false,"given":"Liangkui","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 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