{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:40:05Z","timestamp":1792813205497,"version":"4.5.0"},"reference-count":101,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Hematology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Myeloproliferative neoplasms (MPNs) are a group of clonal hematologic malignancies that include polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis (MF). MPNs are characterized by activating mutations in the JAK\/STAT pathway and an increased risk of transformation to an aggressive form of acute leukemia, termed MPN-blast phase (MPN-BP). MPN-BP is characterized by the presence of \u2a7e20% blasts in the blood or bone marrow and is almost always preceded by an accelerated phase (MPN-AP) defined as \u2a7e10\u201319% blasts in the blood or bone marrow. These advanced forms of disease are associated with poor prognosis with a median overall survival (mOS) of 3\u20135\u2009months in MPN-BP and 13\u2009months in MPN-AP. MPN-AP\/BP has a unique molecular landscape characterized by increased intratumoral complexity. Standard therapies used in de novo acute myeloid leukemia (AML) have not demonstrated improvement in OS. Allogeneic hematopoietic stem cell transplant (HSCT) remains the only curative therapy but is associated with significant morbidity and mortality and infrequently utilized in clinical practice. Therefore, an urgent unmet need persists for effective therapies in this advanced phase patient population. Here, we review the current management and future directions of therapy in MPN-AP\/BP.<\/jats:p>","DOI":"10.1177\/20406207231177282","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T09:18:19Z","timestamp":1687598299000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Treating accelerated and blast phase myeloproliferative neoplasms: progress and challenges"],"prefix":"10.1177","volume":"14","author":[{"given":"Helen O.","family":"Ajufo","sequence":"first","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian A.","family":"Waksal","sequence":"additional","affiliation":[{"name":"The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6167-4322","authenticated-orcid":false,"given":"John O.","family":"Mascarenhas","sequence":"additional","affiliation":[{"name":"The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1079, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raajit K.","family":"Rampal","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,6,22]]},"reference":[{"key":"bibr1-20406207231177282","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2020.12.008"},{"key":"bibr2-20406207231177282","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-3783"},{"key":"bibr3-20406207231177282","first-page":"405","volume":"17","author":"Marcellino B","year":"2019","journal-title":"Clin Adv Hematol 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