{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:36:05Z","timestamp":1792787765939,"version":"4.5.0"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015098","name":"Seoul Metropolitan Government Seoul National University Boramae Medical Center","doi-asserted-by":"publisher","award":["focused clinical research grant-in-aid (03-2020-22"],"award-info":[{"award-number":["focused clinical research grant-in-aid (03-2020-22"]}],"id":[{"id":"10.13039\/501100015098","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korean Society of Hematology"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Hematology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Droplet digital polymerase chain reaction (ddPCR) is an exact method of measurement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We conducted this study to identify the prognostic factors for successful treatment-free remission in patients with chronic-phase chronic myeloid leukemia who discontinued tyrosine kinase inhibitors (TKIs). We also aimed to validate ddPCR for predicting molecular relapse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This is a prospective, multicenter study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We enrolled patients treated with TKIs for at least 3\u2009years with a confirmed sustained deep molecular response (DMR) for at least 1\u2009year. TKI was re-administered in patients who experienced the loss of major molecular response (MMR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 66 patients from five institutions in South Korea were enrolled. During a median follow-up period of 16.5\u2009months, 29\/66 (43.9%) patients experienced molecular relapse; the probability of molecular relapse-free survival (RFS) at 6 or 12\u2009months after TKI discontinuation was 65.6% or 57.8%, respectively, with most molecular relapses occurring within the first 7\u2009months. All patients who lost MMR were re-treated with TKI, and all re-achieved MMR at a median of 2.8\u2009months. E14a2 transcript type ( p\u2009=\u20090.005) and longer DMR duration (\u2a7e48\u2009months) prior to TKI discontinuation ( p\u2009=\u20090.002) were associated with prolonged molecular RFS and with sustained DMR. Patients with both e13a2 transcript type and detectable BCR::ABL1 (\u2a7eMR\n                      <jats:sup>5.0<\/jats:sup>\n                      ) by ddPCR at the time of TKI discontinuation showed shorter duration of molecular RFS ( p\u2009=\u20090.015).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our data suggest that transcript type and BCR::ABL1 transcript levels on ddPCR should be taken into consideration when deciding whether to discontinue TKI therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20406207231205637","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T03:43:12Z","timestamp":1698896592000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of\n                    <i>BCR::ABL1<\/i>\n                    transcript type and droplet digital polymerase chain reaction on successful treatment-free remission in chronic myeloid leukemia patients who discontinued tyrosine kinase inhibitor"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5646-8054","authenticated-orcid":false,"given":"Hyunkyung","family":"Park","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Seoul National University\u2013Seoul Metropolitan Government Boramae Medical Center, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeong-Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chonnam National University, Hwasun Hospital, Hwasun, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Kyun","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kyungpook National University Hospital, Daegu, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoonsuk","family":"Baik","sequence":"additional","affiliation":[{"name":"LAS Inc., Gimpo, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongho","family":"Kim","sequence":"additional","affiliation":[{"name":"LAS Inc., Gimpo, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Yeoun","family":"Lee","sequence":"additional","affiliation":[{"name":"LAS Inc., Gimpo, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee Hyun","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hawk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Yeop","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Sook","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chonnam National University, Hwasun Hospital, Hwasun, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinny","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seonyang","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Inje University, Haeundae Paik Hospital, Busan, South 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