{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:14:17Z","timestamp":1790957657516,"version":"4.1.0"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Hematology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Treatment of pediatric immune thrombocytopenia (ITP) is guided by the risk of bleeding. Intravenous immunoglobulin (IVIg) is one of the first-line therapy options for new-onset pediatric ITP. However, the exact optimal dose of IVIg has not been determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective cohort study included all hospitalized children with newly diagnosed ITP receiving IVIg as first-line therapy during 2010\u20132020. We compared the safety and efficacy of two common IVIg dose regimens, 1 and 2\u2009g\/kg. Outcomes were short and long-term treatment responses and adverse events to the different doses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 168 children were included in our cohort. Eighty-two children were treated with 1\u2009g\/kg of IVIg and 86 with 2\u2009g\/kg. There was no difference in sustained response (platelet count\u2009&gt;\u200920\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      , &gt; 14\u2009days) between the groups (74.3% vs 76.7%, respectively, p\u2009=\u20090.72) and maximal platelet counts following treatment ( p\u2009=\u20090.44). No difference was found regarding the percentage of chronic ITP between the two groups (24.4% in the 1\u2009g\/kg group as compared to 17.4% in the 2\u2009g\/kg group; p\u2009=\u20090.34). Logistic regression analysis demonstrated there was no effect of the IVIg dose on treatment failure and development of chronic ITP. As anticipated, 47.7% of adverse events were in the 2\u2009g\/kg group and 32.9% in the 1\u2009g\/kg group, with borderline statistical significance ( p\u2009=\u20090.06).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The initial treatment of newly diagnosed pediatric ITP using a 1\u2009g\/kg IVIg regimen may give comparable results to the double dose of 2\u2009g\/kg in attaining a prolonged safe hemostatic threshold, without impacting the incidence of chronic disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20406207241279202","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T02:48:54Z","timestamp":1726627734000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Is less more? Intravenous immunoglobulin for pediatric immune thrombocytopenia"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5144-4993","authenticated-orcid":false,"given":"Eyal","family":"Elron","sequence":"first","affiliation":[{"name":"Department of Neonatology, Schneider Children\u2019s Medical Center of Israel, Petah Tikva, Israel"},{"name":"School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Yacobovich","sequence":"additional","affiliation":[{"name":"School of Medicine, Tel Aviv University, Tel Aviv, Israel"},{"name":"Department of Hematology-Oncology, Schneider Children\u2019s Medical Center of Israel, Petah Tikva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orly","family":"Efros","sequence":"additional","affiliation":[{"name":"School of Medicine, Tel Aviv University, Tel Aviv, Israel"},{"name":"Thrombosis & Hemostasis Unit, Sheba Medical Center, Tel Hashomer, Israel"},{"name":"Clalit Health Services, Israel, Tel Aviv, Israel"},{"name":"National Hemophilia and Thrombosis Center, Sheba Medical Center, Tel Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama","family":"Tanous","sequence":"additional","affiliation":[{"name":"Clalit Health Services, Israel, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarina","family":"Levy-Mendelovich","sequence":"additional","affiliation":[{"name":"National Hemophilia and Thrombosis Center, Sheba Medical Center, Tel Hashomer, Israel"},{"name":"Amalia Biron Research Institute of Thrombosis and Hemostasis, School of Medicine, Tel Aviv University, Tel Aviv, Israel"},{"name":"The Sheba Talpiot Medical Leadership Program, Tel Hashomer, Israel"},{"name":"School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esti","family":"Shamba","sequence":"additional","affiliation":[{"name":"Department of Hematology-Oncology, Schneider Children\u2019s Medical Center of Israel, Petah Tikva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orna","family":"Steinberg-Shemer","sequence":"additional","affiliation":[{"name":"School of Medicine, Tel Aviv University, Tel Aviv, Israel"},{"name":"Department of Hematology-Oncology, Schneider Children\u2019s Medical Center of Israel, Petah Tikva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracie","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Department of Hematology-Oncology, Schneider Children\u2019s Medical Center of Israel, Petah Tikva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shai","family":"Izraeli","sequence":"additional","affiliation":[{"name":"School of Medicine, Tel Aviv University, Tel Aviv, Israel"},{"name":"Department of Hematology-Oncology, Schneider Children\u2019s Medical Center of Israel, Petah Tikva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oded","family":"Gilad","sequence":"additional","affiliation":[{"name":"Department of Hematology-Oncology, Schneider Children\u2019s Medical Center of Israel, 14 Kaplan street, Petah Tikva 4920235, Israel"},{"name":"School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"key":"bibr1-20406207241279202","first-page":"30","volume":"8","author":"Saeidi S","year":"2014","journal-title":"Int J Hematol Oncol Stem Cell 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