{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:04:16Z","timestamp":1788537856061,"version":"build-2803163510"},"reference-count":117,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Chongqing Science-Health Project","award":["2023ZDXM022"],"award-info":[{"award-number":["2023ZDXM022"]}]},{"DOI":"10.13039\/501100001809","name":"Chinese National Natural Science Foundation","doi-asserted-by":"crossref","award":["82170161"],"award-info":[{"award-number":["82170161"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Hematology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Acute leukemia (AL) is a rare yet perilous malignancy. Currently, the primary treatment for AL involves combination chemotherapy as the cornerstone of comprehensive measures, alongside hematopoietic stem cell transplantation as a radical approach. However, despite these interventions, mortality rates remain high, particularly among refractory\/recurrent patients or elderly individuals with a poor prognosis. Acetylation, a form of epigenetic regulation, has emerged as a promising therapeutic avenue for treating AL. Recent studies have highlighted the potential of acetylation regulation as a novel treatment pathway. Histone deacetylase inhibitors (HDACis) play a pivotal role in modulating the differentiation and development of tumor cells through diverse pathways, simultaneously impacting the maturation and function of lymphocytes. HDACis demonstrate promise in enhancing survival rates and achieving a complete response in both acute myeloid leukemia and acute T-lymphoblastic leukemia patients. This article provides a comprehensive review of the advancements in HDACi therapy for AL, shedding light on its potential implications for clinical practice.<\/jats:p>","DOI":"10.1177\/20406207241283277","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T21:13:52Z","timestamp":1729113232000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Histone deacetylase inhibitors: targeting epigenetic regulation in the treatment of acute leukemia"],"prefix":"10.1177","volume":"15","author":[{"given":"Tong","family":"Xiao","sequence":"first","affiliation":[{"name":"Medical Center of Hematology, State Key Laboratory of Trauma, Burn and Combined Injury, Xinqiao Hospital, Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Chen","sequence":"additional","affiliation":[{"name":"Medical Center of Hematology, State Key Laboratory of Trauma, Burn and Combined Injury, Xinqiao Hospital, Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Xie","sequence":"additional","affiliation":[{"name":"Medical Center of Hematology, State Key Laboratory of Trauma, Burn and Combined Injury, Xinqiao Hospital, Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Yang","sequence":"additional","affiliation":[{"name":"Medical Center of Hematology, State Key Laboratory of Trauma, Burn and Combined Injury, Xinqiao Hospital, Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhong","family":"Wu","sequence":"additional","affiliation":[{"name":"Medical Center of Hematology, State Key Laboratory of Trauma, Burn and Combined Injury, Xinqiao Hospital, Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2336-976X","authenticated-orcid":false,"given":"Lei","family":"Gao","sequence":"additional","affiliation":[{"name":"Medical Center of Hematology, State Key Laboratory of Trauma, Burn and Combined Injury, Xinqiao Hospital, Army Medical University, No. 183, Xinqiao Street, Shapingba District, Chongqing 400037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,16]]},"reference":[{"key":"bibr1-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-3119"},{"key":"bibr2-20406207241283277","doi-asserted-by":"crossref","first-page":"108114","DOI":"10.1016\/j.intimp.2021.108114","volume":"100","author":"Mehrpouri M","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"bibr3-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-019-0675-4"},{"key":"bibr4-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1787609"},{"key":"bibr5-20406207241283277","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4103\/abr.abr_142_19","volume":"8","author":"Kavoosi F","year":"2019","journal-title":"Adv Biomed Res"},{"key":"bibr6-20406207241283277","doi-asserted-by":"publisher","DOI":"10.3390\/nu10060731"},{"key":"bibr7-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.76.052705.162114"},{"key":"bibr8-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.013"},{"key":"bibr9-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(200007)184:1<1::AID-JCP1>3.0.CO;2-7"},{"key":"bibr10-20406207241283277","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0002020","volume":"3","author":"Firestein R","year":"2008","journal-title":"PLoS ONE"},{"key":"bibr11-20406207241283277","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12943-018-0855-4","volume":"17","author":"Yang Q","year":"2018","journal-title":"Mol Cancer"},{"key":"bibr12-20406207241283277","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1111\/cas.13062","volume":"107","author":"Imai Y","year":"2016","journal-title":"Cancer Sci"},{"key":"bibr13-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2001-2-4-reviews0003"},{"key":"bibr14-20406207241283277","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.breast.2018.12.001","volume":"43","author":"Zucchetti B","year":"2019","journal-title":"Breast"},{"key":"bibr15-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2007.01.001"},{"key":"bibr16-20406207241283277","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12943-019-1127-7","volume":"19","author":"Wang P","year":"2020","journal-title":"Mol Cancer"},{"key":"bibr17-20406207241283277","doi-asserted-by":"crossref","first-page":"20429","DOI":"10.1073\/pnas.1007804107","volume":"107","author":"Fujiwara T","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"bibr18-20406207241283277","doi-asserted-by":"crossref","first-page":"16894","DOI":"10.1073\/pnas.0607926103","volume":"103","author":"Chen G-Y","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"bibr19-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.23.10338-10351.2005"},{"key":"bibr20-20406207241283277","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.molcel.2007.06.039","volume":"27","author":"Saleque S","year":"2007","journal-title":"Mol Cell"},{"key":"bibr21-20406207241283277","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3892\/ijo.2015.3275","volume":"48","author":"Xu H","year":"2016","journal-title":"Int J Oncol"},{"key":"bibr22-20406207241283277","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/00062752-200207000-00010","volume":"9","author":"Melnick A","year":"2002","journal-title":"Curr Opin Hematol"},{"key":"bibr23-20406207241283277","doi-asserted-by":"crossref","first-page":"519","DOI":"10.2174\/138955711795843347","volume":"11","author":"Petrella A","year":"2011","journal-title":"Mini Rev Med Chem"},{"key":"bibr24-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.6.3003"},{"key":"bibr25-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.15.1210"},{"key":"bibr26-20406207241283277","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071414"},{"key":"bibr27-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104309200"},{"key":"bibr28-20406207241283277","doi-asserted-by":"crossref","first-page":"907","DOI":"10.4161\/epi.25574","volume":"8","author":"Kortenhorst MS","year":"2013","journal-title":"Epigenetics"},{"key":"bibr29-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.03.025"},{"key":"bibr30-20406207241283277","doi-asserted-by":"crossref","first-page":"89","DOI":"10.31557\/APJCP.2021.22.S1.89","volume":"22","author":"Sanaei M","year":"2021","journal-title":"Asian Pac J Cancer Prev"},{"key":"bibr31-20406207241283277","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.3892\/or_00001026","volume":"24","author":"Yamanegi K","year":"2010","journal-title":"Oncol Rep"},{"key":"bibr32-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-336743"},{"key":"bibr33-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.180316197"},{"key":"bibr34-20406207241283277","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.4161\/auto.6.8.13365","volume":"6","author":"Liu Y-L","year":"2010","journal-title":"Autophagy"},{"key":"bibr35-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115212"},{"key":"bibr36-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0b013e328364c0ed"},{"key":"bibr37-20406207241283277","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.5966\/sctm.2015-0331","volume":"5","author":"Ali D","year":"2016","journal-title":"Stem Cells Transl Med"},{"key":"bibr38-20406207241283277","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00277-009-0793-8","volume":"89","author":"Galli M","year":"2010","journal-title":"Ann Hematol"},{"key":"bibr39-20406207241283277","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1007\/s40265-022-01744-w","volume":"82","author":"Dhillon S","year":"2022","journal-title":"Drugs"},{"key":"bibr40-20406207241283277","doi-asserted-by":"crossref","first-page":"292","DOI":"10.18632\/genesandcancer.117","volume":"7","author":"Li Y","year":"2016","journal-title":"Genes Cancer"},{"key":"bibr41-20406207241283277","doi-asserted-by":"crossref","first-page":"105969","DOI":"10.1016\/j.phrs.2021.105969","volume":"176","author":"Shen Y","year":"2022","journal-title":"Pharmacol Res"},{"key":"bibr42-20406207241283277","doi-asserted-by":"crossref","DOI":"10.1016\/j.exphem.2012.10.013","volume":"41","author":"Amaru Calzada A","year":"2013","journal-title":"Exp Hematol"},{"key":"bibr43-20406207241283277","doi-asserted-by":"crossref","first-page":"6094","DOI":"10.3892\/mmr.2017.7355","volume":"16","author":"Li F","year":"2017","journal-title":"Mol Med Rep"},{"key":"bibr44-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17559"},{"key":"bibr45-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1038\/nm1161"},{"key":"bibr46-20406207241283277","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1128\/JVI.03406-13","volume":"88","author":"Shulak L","year":"2014","journal-title":"J Virol"},{"key":"bibr47-20406207241283277","doi-asserted-by":"crossref","first-page":"16036","DOI":"10.1038\/cddiscovery.2016.36","volume":"2","author":"Zhang Q","year":"2016","journal-title":"Cell Death Discov"},{"key":"bibr48-20406207241283277","doi-asserted-by":"crossref","DOI":"10.1038\/bcj.2015.83","volume":"5","author":"Valdez BC","year":"2015","journal-title":"Blood Cancer J"},{"key":"bibr49-20406207241283277","first-page":"859","volume":"12","author":"Smolewski P","year":"2017","journal-title":"Expert Opin Drug Discov"},{"key":"bibr50-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M106699200"},{"key":"bibr51-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2133"},{"key":"bibr52-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2010.510514"},{"key":"bibr53-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.306"},{"key":"bibr54-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2014.04.004"},{"key":"bibr55-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408732102"},{"key":"bibr56-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.182372299"},{"key":"bibr57-20406207241283277","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/leu.2010.244","volume":"25","author":"Song W","year":"2011","journal-title":"Leukemia"},{"key":"bibr58-20406207241283277","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.neuroscience.2010.04.074","volume":"169","author":"Zhang ZY","year":"2010","journal-title":"Neuroscience"},{"key":"bibr59-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2007.02678.x"},{"key":"bibr60-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-04-019711"},{"key":"bibr61-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v25.i2.10"},{"key":"bibr62-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.06.016"},{"key":"bibr63-20406207241283277","doi-asserted-by":"crossref","first-page":"8372","DOI":"10.4049\/jimmunol.181.12.8372","volume":"181","author":"Chang S","year":"2008","journal-title":"J Immunol"},{"key":"bibr64-20406207241283277","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1471-2407-3-30","volume":"3","author":"Moreira JMA","journal-title":"BMC Cancer"},{"key":"bibr65-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80605-6"},{"key":"bibr66-20406207241283277","doi-asserted-by":"crossref","first-page":"40640","DOI":"10.1074\/jbc.M407576200","volume":"279","author":"Morinobu A","year":"2004","journal-title":"J Biol Chem"},{"key":"bibr67-20406207241283277","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/s41577-018-0037-z","volume":"18","author":"Ellmeier W","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"bibr68-20406207241283277","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/ni.2008","volume":"12","author":"Navarro MN","year":"2011","journal-title":"Nat Immunol"},{"key":"bibr69-20406207241283277","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/ni872","volume":"4","author":"Messi M","year":"2003","journal-title":"Nat Immunol"},{"key":"bibr70-20406207241283277","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.4049\/jimmunol.177.2.1062","volume":"177","author":"Northrop JK","year":"2006","journal-title":"J Immunol"},{"key":"bibr71-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0062-8"},{"key":"bibr72-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.04.010"},{"key":"bibr73-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2010.08.013"},{"key":"bibr74-20406207241283277","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1182\/blood-2011-10-292003","volume":"119","author":"Akimova T","year":"2012","journal-title":"Blood"},{"key":"bibr75-20406207241283277","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1158\/1078-0432.CCR-13-1576","volume":"20","author":"Govindaraj C","year":"2014","journal-title":"Clin Cancer Res"},{"key":"bibr76-20406207241283277","first-page":"292","volume":"41","author":"Zhao H","year":"2020","journal-title":"Chin J Hematol"},{"key":"bibr77-20406207241283277","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.leukres.2018.05.008","volume":"70","author":"Zuo M","year":"2018","journal-title":"Leuk Res"},{"key":"bibr78-20406207241283277","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02486"},{"key":"bibr79-20406207241283277","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.bbmt.2016.12.624","volume":"23","author":"Locke FL","year":"2017","journal-title":"Biol Blood Marrow Transplant"},{"key":"bibr80-20406207241283277","doi-asserted-by":"crossref","first-page":"115594","DOI":"10.1016\/j.ejmech.2023.115594","volume":"258","author":"Amin SA","year":"2023","journal-title":"Eur J Med Chem"},{"key":"bibr81-20406207241283277","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.3390\/cancers15102808","volume":"15","author":"Pal D","year":"2023","journal-title":"Cancers"},{"key":"bibr82-20406207241283277","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1080\/10428194.2019.1691195","volume":"61","author":"Guan W","year":"2020","journal-title":"Leukemia & Lymphoma"},{"key":"bibr83-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa0314"},{"key":"bibr84-20406207241283277","doi-asserted-by":"crossref","first-page":"66255","DOI":"10.18632\/oncotarget.11357","volume":"7","author":"Richter L","year":"2016","journal-title":"Oncotarget"},{"key":"bibr85-20406207241283277","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.stem.2015.08.004","volume":"17","author":"Qi J","year":"2015","journal-title":"Cell Stem Cell"},{"key":"bibr86-20406207241283277","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1158\/1541-7786.MCR-18-0922","volume":"17","author":"Richter LE","year":"2019","journal-title":"Mol Cancer Res"},{"key":"bibr87-20406207241283277","first-page":"699","volume":"133","author":"Xu Q-Y","year":"2020","journal-title":"Chin Med J"},{"key":"bibr88-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21589"},{"key":"bibr89-20406207241283277","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2174\/156800961506150805153230","volume":"15","author":"Li Y","year":"2015","journal-title":"Curr Cancer Drug Targets"},{"key":"bibr90-20406207241283277","doi-asserted-by":"crossref","first-page":"855570","DOI":"10.3389\/fonc.2022.855570","volume":"12","author":"Ma X","year":"2022","journal-title":"Front Oncol"},{"key":"bibr91-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2011.02.021"},{"key":"bibr92-20406207241283277","doi-asserted-by":"crossref","first-page":"5397","DOI":"10.1038\/s41467-021-25664-7","volume":"12","author":"Khateb A","year":"2021","journal-title":"Nat Commun"},{"key":"bibr93-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.182"},{"key":"bibr94-20406207241283277","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11111794"},{"key":"bibr95-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.3265"},{"key":"bibr96-20406207241283277","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.096545"},{"key":"bibr97-20406207241283277","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.3109\/10428194.2015.1018248","volume":"56","author":"How J","year":"2015","journal-title":"Leuk Lymphoma"},{"key":"bibr98-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.4223"},{"key":"bibr99-20406207241283277","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2174\/1568026619666190122144949","volume":"19","author":"Li Y","year":"2019","journal-title":"Curr Top Med Chem"},{"key":"bibr100-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-231548"},{"key":"bibr101-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.10.2434"},{"key":"bibr102-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1177\/1078155216634178"},{"key":"bibr103-20406207241283277","first-page":"143","volume":"13","author":"Wang J","year":"2017","journal-title":"Front Immunol"},{"key":"bibr104-20406207241283277","doi-asserted-by":"publisher","DOI":"10.3390\/genes12081118"},{"key":"bibr105-20406207241283277","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1182\/blood-2018-99-113712","volume":"132","author":"Zhou H","year":"2018","journal-title":"Blood"},{"key":"bibr106-20406207241283277","doi-asserted-by":"crossref","first-page":"1096529","DOI":"10.3389\/fmed.2023.1096529","volume":"10","author":"Li X-Y","year":"2023","journal-title":"Front Med"},{"key":"bibr107-20406207241283277","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.2147\/CMAR.S242903","volume":"12","author":"Chen F","year":"2020","journal-title":"Cancer Manage Res"},{"key":"bibr108-20406207241283277","doi-asserted-by":"crossref","first-page":"710545","DOI":"10.3389\/fonc.2021.710545","volume":"11","author":"Liu J","year":"2021","journal-title":"Front Oncol"},{"key":"bibr109-20406207241283277","first-page":"1391","volume":"40","author":"Kanno S-I","year":"2012","journal-title":"Int J Oncol"},{"key":"bibr110-20406207241283277","first-page":"419","volume":"89","author":"Roma\u0144ski A","year":"2004","journal-title":"Haematologica"},{"key":"bibr111-20406207241283277","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1182\/blood.V118.21.1520.1520","volume":"118","author":"Agirre X","year":"2011","journal-title":"Blood"},{"key":"bibr112-20406207241283277","doi-asserted-by":"crossref","first-page":"173050","DOI":"10.1016\/j.ejphar.2020.173050","volume":"875","author":"Mehrpouri M","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"bibr113-20406207241283277","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1182\/blood.V112.11.2923.2923","volume":"112","author":"Leclerc GJ","year":"2008","journal-title":"Blood"},{"key":"bibr114-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-1290"},{"key":"bibr115-20406207241283277","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-0516"},{"key":"bibr116-20406207241283277","doi-asserted-by":"crossref","first-page":"72373","DOI":"10.1039\/C5RA12606A","volume":"88","author":"Halder AK","year":"2015","journal-title":"RSC Adv"},{"key":"bibr117-20406207241283277","doi-asserted-by":"crossref","first-page":"112628","DOI":"10.1016\/j.ejmech.2020.112628","volume":"203","author":"Fan W","year":"2020","journal-title":"Eur J Med Chem"}],"container-title":["Therapeutic Advances in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20406207241283277","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20406207241283277","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20406207241283277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:17:16Z","timestamp":1777591036000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20406207241283277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":117,"alternative-id":["10.1177\/20406207241283277"],"URL":"https:\/\/doi.org\/10.1177\/20406207241283277","relation":{},"ISSN":["2040-6207","2040-6215"],"issn-type":[{"value":"2040-6207","type":"print"},{"value":"2040-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"20406207241283277"}}