{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:05:34Z","timestamp":1777878334664,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Six major talent peak projects in Jiangsu Province","award":["RJFW-40"],"award-info":[{"award-number":["RJFW-40"]}]},{"name":"Jiangsu Province \u201c333 High-level Talent Training Project\u201d","award":["RJFW-40"],"award-info":[{"award-number":["RJFW-40"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Hematology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>While carfilzomib has shown effectiveness in treating relapsed or refractory multiple myeloma (RRMM), the best frequency of dosing is still debated. This meta-analysis aims to investigate the differences in safety and effectiveness between once-weekly and twice-weekly carfilzomib treatment schedules for patients with RRMM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A thorough search of five databases was performed. We calculated pooled relative risks (RRs), hazard ratios (HRs), and 95% confidence intervals (95% CIs), and conducted heterogeneity and sensitivity analyses using StateMP 18 software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Five studies met the inclusion criteria. Analysis indicated that once-weekly carfilzomib significantly enhanced progression-free survival (HR: 0.80, 95% CI: 0.69\u20130.94,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). However, no statistical difference was observed in the pooled RRs for overall response rate (RR: 1.13, 95% CI: 0.94\u20131.38,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.198) and complete response or better (RR: 2.08, 95% CI: 0.65\u20136.65,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.217). The once-weekly regimen was notably associated with a reduction in adverse events (RR: 0.98, 95% CI: 0.96\u20131.00,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047) relative to the twice-weekly regimen.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The results propose once-weekly carfilzomib as a viable alternative treatment option for RRMM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20406207251359650","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T11:49:20Z","timestamp":1759751360000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative analysis of once-weekly versus twice-weekly carfilzomib in relapsed and refractory multiple myeloma: a meta-analysis"],"prefix":"10.1177","volume":"16","author":[{"given":"Wenhao","family":"Yang","sequence":"first","affiliation":[{"name":"The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangtu","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Hematology, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaosu","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Oncology, Xuzhou Hospital of Traditional Chinese Medicine, Xuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0753-7481","authenticated-orcid":false,"given":"Haiwen","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Hematology, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, No. 155 Hanzhong Road, Qinhuai District, Nanjing 210029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-018-0346-9"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-022-05058-5"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/20406207211019612"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00135-5"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020888"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12338"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0517-6"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30578-8"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00464-7"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.27"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.2010"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-018-0170-0"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-563759"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-114311"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-05-785246"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-11-683854"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30354-1"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2020.1832672"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2945"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-020-03013-6"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2024013101"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.208272"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.282225"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2019.04.002"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008346"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020010452"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000722"}],"container-title":["Therapeutic 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